Association between increased intestinal permeability and disease: A systematic review

Leech, B; Schloss, J; Steel, A

Association between increased intestinal permeability and disease: A systematic review

Leech, B Schloss, J

Steel, A

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Publication Type:: Journal Article
Citation:: Advances in Integrative Medicine, 2019, 6 (1), pp. 23 - 34
Issue Date:: 2019-03-01

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Field	Value	Language
dc.contributor.author	Leech, B	en_US
dc.contributor.author	Schloss, J https://orcid.org/0000-0003-1643-6215	en_US
dc.contributor.author	Steel, A https://orcid.org/0000-0001-6643-9444	en_US
dc.date.issued	2019-03-01	en_US
dc.identifier.citation	Advances in Integrative Medicine, 2019, 6 (1), pp. 23 - 34	en_US
dc.identifier.issn	2212-9588	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130466
dc.description.abstract	© 2018 Elsevier Ltd Objective: Increased intestinal permeability (IP) may play an important role in health and disease. The purpose of this review is to explore the association between IP and diseases frequently found within clinical practice. Design and methods: A systematic literature search was conducted up until July 2018 in MEDLINE, PubMed, EMBASE and AMED. A total of 48 articles met the inclusion/exclusion criteria. Results: IP is strongly associated with autoimmune disease and liver conditions, with the estimated prevalence of 25–87.5% and 17–65% respectively. IP also correlates with diabetes (30–65%), food allergies/hypersensitivity, irritable bowel syndrome (35.6%), polycystic ovary syndrome and autism (36.7%). Disease severity in addition to clinical symptoms of menstrual disorders, food allergy or hypersensitivity directly correlates with IP. Finally, the severity of IP appears to be exacerbated by the presence of dysbiosis, inflammation and glucose metabolism disorders. Conclusions: IP is a potentially influential factor that coincides with a variety of health conditions and diseases. IP should be considered as a factor in the pathophysiology and differential diagnosis for patient's presenting with autoimmune diseases, non-alcoholic fatty liver disease, liver cirrhosis, polycystic ovary syndrome, irritable bowel syndrome, diabetes, autism, food allergies and food hypersensitivity. Further research is required to determine if IP plays a pathogenic role in the progression and development of disease or whether the disease causes IP. While the clinical significance between IP and these diseases is unclear, the findings of the review suggest the treatment of IP in patients presenting with these conditions may warrant the consideration of clinicians.	en_US
dc.relation.ispartof	Advances in Integrative Medicine	en_US
dc.relation.isbasedon	10.1016/j.aimed.2018.08.003	en_US
dc.title	Association between increased intestinal permeability and disease: A systematic review	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	6	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1104 Complementary and Alternative Medicine	en_US
utslib.for	1111 Nutrition and Dietetics	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

© 2018 Elsevier Ltd Objective: Increased intestinal permeability (IP) may play an important role in health and disease. The purpose of this review is to explore the association between IP and diseases frequently found within clinical practice. Design and methods: A systematic literature search was conducted up until July 2018 in MEDLINE, PubMed, EMBASE and AMED. A total of 48 articles met the inclusion/exclusion criteria. Results: IP is strongly associated with autoimmune disease and liver conditions, with the estimated prevalence of 25–87.5% and 17–65% respectively. IP also correlates with diabetes (30–65%), food allergies/hypersensitivity, irritable bowel syndrome (35.6%), polycystic ovary syndrome and autism (36.7%). Disease severity in addition to clinical symptoms of menstrual disorders, food allergy or hypersensitivity directly correlates with IP. Finally, the severity of IP appears to be exacerbated by the presence of dysbiosis, inflammation and glucose metabolism disorders. Conclusions: IP is a potentially influential factor that coincides with a variety of health conditions and diseases. IP should be considered as a factor in the pathophysiology and differential diagnosis for patient's presenting with autoimmune diseases, non-alcoholic fatty liver disease, liver cirrhosis, polycystic ovary syndrome, irritable bowel syndrome, diabetes, autism, food allergies and food hypersensitivity. Further research is required to determine if IP plays a pathogenic role in the progression and development of disease or whether the disease causes IP. While the clinical significance between IP and these diseases is unclear, the findings of the review suggest the treatment of IP in patients presenting with these conditions may warrant the consideration of clinicians.

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http://hdl.handle.net/10453/130466