Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles

Suñer, S; Gowland, N; Craven, R; Joffe, R; Emami, N; Tipper, JL

Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles

Suñer, S Gowland, N Craven, R Joffe, R Emami, N Tipper, JL

Permalink

Publication Type:: Journal Article
Citation:: Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2018, 106 (1), pp. 183 - 190
Issue Date:: 2018-01-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Accepted Manuscript VersionAdobe PDF (213.67 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Suñer, S	en_US
dc.contributor.author	Gowland, N	en_US
dc.contributor.author	Craven, R	en_US
dc.contributor.author	Joffe, R	en_US
dc.contributor.author	Emami, N	en_US
dc.contributor.author	Tipper, JL https://orcid.org/0000-0002-8719-0323	en_US
dc.date.available	2016-11-08	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2018, 106 (1), pp. 183 - 190	en_US
dc.identifier.issn	1552-4973	en_US
dc.identifier.uri	http://hdl.handle.net/10453/131622
dc.description.abstract	© 2016 Wiley Periodicals, Inc. In the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultrahigh molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of this study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. This study revealed that low concentrations of GO nanoparticles (0.5 wt %) do not significantly alter the wear performance of UHMWPE. In contrast, the addition of higher concentrations (2 wt %) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not show any adverse effects on L929 fibroblast and PBMNC viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not significantly affect the inflammatory response to wear particles. Further work is required to optimize the manufacturing processes to improve the mechanical properties of the nanocomposites and additional biocompatibility testing should be performed to understand the potential clinical application of these materials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 183–190, 2018.	en_US
dc.relation.ispartof	Journal of Biomedical Materials Research - Part B Applied Biomaterials	en_US
dc.relation.isbasedon	10.1002/jbm.b.33821	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Biomedical Engineering	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Fibroblasts	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Graphite	en_US
dc.subject.mesh	Polyethylenes	en_US
dc.subject.mesh	Materials Testing	en_US
dc.subject.mesh	Nanocomposites	en_US
dc.title	Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	106	en_US
utslib.for	0912 Materials Engineering	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	106	en_US

Abstract:

© 2016 Wiley Periodicals, Inc. In the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultrahigh molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of this study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. This study revealed that low concentrations of GO nanoparticles (0.5 wt %) do not significantly alter the wear performance of UHMWPE. In contrast, the addition of higher concentrations (2 wt %) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not show any adverse effects on L929 fibroblast and PBMNC viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not significantly affect the inflammatory response to wear particles. Further work is required to optimize the manufacturing processes to improve the mechanical properties of the nanocomposites and additional biocompatibility testing should be performed to understand the potential clinical application of these materials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 183–190, 2018.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/131622