Reproductive outcomes after a childhood and adolescent young adult cancer diagnosis in female cancer survivors: A systematic review and meta-analysis

Gerstl, B; Sullivan, E; Chong, S; Chia, D; Wand, H; Anazodo, A

Reproductive outcomes after a childhood and adolescent young adult cancer diagnosis in female cancer survivors: A systematic review and meta-analysis

Gerstl, B Sullivan, E

Chong, S Chia, D Wand, H Anazodo, A

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Publication Type:: Journal Article
Citation:: Journal of Adolescent and Young Adult Oncology, 2018, 7 (6), pp. 627 - 642
Issue Date:: 2018-12-01

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Field	Value	Language
dc.contributor.author	Gerstl, B	en_US
dc.contributor.author	Sullivan, E https://orcid.org/0000-0002-8718-2753	en_US
dc.contributor.author	Chong, S	en_US
dc.contributor.author	Chia, D	en_US
dc.contributor.author	Wand, H	en_US
dc.contributor.author	Anazodo, A	en_US
dc.date.issued	2018-12-01	en_US
dc.identifier.citation	Journal of Adolescent and Young Adult Oncology, 2018, 7 (6), pp. 627 - 642	en_US
dc.identifier.issn	2156-5333	en_US
dc.identifier.uri	http://hdl.handle.net/10453/131644
dc.description.abstract	© Mary Ann Liebert, Inc., publishers 2018. Improvements in cancer therapy for childhood and adolescent and young adult (AYA) survivors have increased in excess of 80% among pediatric patients and in excess of 85% among AYA cancer patients. Our research group explored the late effects consequences of cancer treatment on pregnancy and birth outcomes subsequent to a childhood (0-14 years) or AYA (15-25 years) diagnosis of cancer in female cancer survivors. Embase and Medline databases were searched. There were 17 review (n = 10 matched and n = 7 unmatched) studies that met the inclusion criteria. Subanalyses were conducted on 10 matched studies. The median age for all studies for patients at diagnosis and birth was 11 and 27 years, respectively. In matched cohort studies, female childhood and AYA cancer patients, who received chemotherapy alone, had a pooled estimated rate of 18% of experiencing a live birth compared with 10% of females who received radiotherapy alone and subsequently had a live birth. Females who received surgery alone reported higher pooled estimated rates of 44% for a live birth. For matched retrospective review studies, 79% (n = 973) of women experienced a live birth, of which 22% of these babies were born preterm. This meta-analysis found lower birth rates for survivors. Access to fertility-related information and discussions around fertility preservation options and oncofertility psychosocial support should be offered to all cancer patients and their families before starting cancer treatment.	en_US
dc.relation.ispartof	Journal of Adolescent and Young Adult Oncology	en_US
dc.relation.isbasedon	10.1089/jayao.2018.0036	en_US
dc.title	Reproductive outcomes after a childhood and adolescent young adult cancer diagnosis in female cancer survivors: A systematic review and meta-analysis	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	7	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© Mary Ann Liebert, Inc., publishers 2018. Improvements in cancer therapy for childhood and adolescent and young adult (AYA) survivors have increased in excess of 80% among pediatric patients and in excess of 85% among AYA cancer patients. Our research group explored the late effects consequences of cancer treatment on pregnancy and birth outcomes subsequent to a childhood (0-14 years) or AYA (15-25 years) diagnosis of cancer in female cancer survivors. Embase and Medline databases were searched. There were 17 review (n = 10 matched and n = 7 unmatched) studies that met the inclusion criteria. Subanalyses were conducted on 10 matched studies. The median age for all studies for patients at diagnosis and birth was 11 and 27 years, respectively. In matched cohort studies, female childhood and AYA cancer patients, who received chemotherapy alone, had a pooled estimated rate of 18% of experiencing a live birth compared with 10% of females who received radiotherapy alone and subsequently had a live birth. Females who received surgery alone reported higher pooled estimated rates of 44% for a live birth. For matched retrospective review studies, 79% (n = 973) of women experienced a live birth, of which 22% of these babies were born preterm. This meta-analysis found lower birth rates for survivors. Access to fertility-related information and discussions around fertility preservation options and oncofertility psychosocial support should be offered to all cancer patients and their families before starting cancer treatment.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/131644