Relationships between maternal obesity and maternal and neonatal iron status

Flynn, AC; Begum, S; White, SL; Dalrymple, K; Gill, C; Alwan, NA; Kiely, M; Latunde-Dada, G; Bell, R; Briley, AL; Nelson, SM; Oteng-Ntim, E; Sandall, J; Sanders, TA; Whitworth, M; Murray, DM; Kenny, LC; Poston, L

Relationships between maternal obesity and maternal and neonatal iron status

Flynn, AC Begum, S White, SL Dalrymple, K Gill, C Alwan, NA Kiely, M Latunde-Dada, G Bell, R Briley, AL Nelson, SM Oteng-Ntim, E Sandall, J

Sanders, TA Whitworth, M Murray, DM Kenny, LC Poston, L

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Publication Type:: Journal Article
Citation:: Nutrients, 2018, 10 (8)
Issue Date:: 2018-08-01

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Field	Value	Language
dc.contributor.author	Flynn, AC	en_US
dc.contributor.author	Begum, S	en_US
dc.contributor.author	White, SL	en_US
dc.contributor.author	Dalrymple, K	en_US
dc.contributor.author	Gill, C	en_US
dc.contributor.author	Alwan, NA	en_US
dc.contributor.author	Kiely, M	en_US
dc.contributor.author	Latunde-Dada, G	en_US
dc.contributor.author	Bell, R	en_US
dc.contributor.author	Briley, AL	en_US
dc.contributor.author	Nelson, SM	en_US
dc.contributor.author	Oteng-Ntim, E	en_US
dc.contributor.author	Sandall, J https://orcid.org/0000-0003-2000-743X	en_US
dc.contributor.author	Sanders, TA	en_US
dc.contributor.author	Whitworth, M	en_US
dc.contributor.author	Murray, DM	en_US
dc.contributor.author	Kenny, LC	en_US
dc.contributor.author	Poston, L	en_US
dc.date.available	2018-07-24	en_US
dc.date.issued	2018-08-01	en_US
dc.identifier.citation	Nutrients, 2018, 10 (8)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133130
dc.description.abstract	© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Obesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese (n = 245, BMI ≥ 30 kg/m2) and normal weight (n = 245, BMI < 25 kg/m2) age matched pregnant women collected at approximately 15 weeks’ gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C-reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women (P < 0.001). Women from ethnic minority groups (n = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.	en_US
dc.relation.ispartof	Nutrients	en_US
dc.relation.isbasedon	10.3390/nu10081000	en_US
dc.subject.mesh	Fetal Blood	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pregnancy Complications	en_US
dc.subject.mesh	Anemia, Iron-Deficiency	en_US
dc.subject.mesh	Obesity	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	C-Reactive Protein	en_US
dc.subject.mesh	Receptors, Transferrin	en_US
dc.subject.mesh	Interleukin-6	en_US
dc.subject.mesh	Body Mass Index	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Mothers	en_US
dc.subject.mesh	Nutritional Status	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Maternal-Fetal Exchange	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Ethnic Groups	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Ferritins	en_US
dc.subject.mesh	Hepcidins	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	Relationships between maternal obesity and maternal and neonatal iron status	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	10	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
utslib.for	0908 Food Sciences	en_US
utslib.for	1111 Nutrition and Dietetics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Midwifery
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Obesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese (n = 245, BMI ≥ 30 kg/m2) and normal weight (n = 245, BMI < 25 kg/m2) age matched pregnant women collected at approximately 15 weeks’ gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C-reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women (P < 0.001). Women from ethnic minority groups (n = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/133130