A Reappraisal of Circulating Fetal Cell Noninvasive Prenatal Testing

Rezaei, M; Winter, M; Zander-Fox, D; Whitehead, C; Liebelt, J; Warkiani, ME; Hardy, T; Thierry, B

A Reappraisal of Circulating Fetal Cell Noninvasive Prenatal Testing

Rezaei, M Winter, M Zander-Fox, D Whitehead, C Liebelt, J Warkiani, ME

Hardy, T Thierry, B

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Publication Type:: Journal Article
Citation:: Trends in Biotechnology, 2019, 37 (6), pp. 632 - 644
Issue Date:: 2019-06-01

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Field	Value	Language
dc.contributor.author	Rezaei, M	en_US
dc.contributor.author	Winter, M	en_US
dc.contributor.author	Zander-Fox, D	en_US
dc.contributor.author	Whitehead, C	en_US
dc.contributor.author	Liebelt, J	en_US
dc.contributor.author	Warkiani, ME https://orcid.org/0000-0002-4184-1944	en_US
dc.contributor.author	Hardy, T	en_US
dc.contributor.author	Thierry, B	en_US
dc.date.available	2018-11-05	en_US
dc.date.issued	2019-06-01	en_US
dc.identifier.citation	Trends in Biotechnology, 2019, 37 (6), pp. 632 - 644	en_US
dc.identifier.issn	0167-7799	en_US
dc.identifier.uri	http://hdl.handle.net/10453/134092
dc.description.abstract	© 2018 Elsevier Ltd New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1143377
dc.relation.ispartof	Trends in Biotechnology	en_US
dc.relation.isbasedon	10.1016/j.tibtech.2018.11.001	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biotechnology	en_US
dc.subject.mesh	Fetus	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Predictive Value of Tests	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	Noninvasive Prenatal Testing	en_US
dc.title	A Reappraisal of Circulating Fetal Cell Noninvasive Prenatal Testing	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	37	en_US
utslib.for	1004 Medical Biotechnology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	10 Technology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	37	en_US

Abstract:

© 2018 Elsevier Ltd New tools for higher-resolution fetal genome analysis including microarray and next-generation sequencing have revolutionized prenatal screening. This article provides commentary on this rapidly advancing field and a future perspective emphasizing circulating fetal cell (CFC) utility. Despite the tremendous technological challenges associated with their reliable and cost-effective isolation from maternal blood, CFCs have a strong potential to bridge the gap between the diagnostic sensitivity of invasive procedures and the desirable noninvasive nature of cell-free fetal DNA (cffDNA). Considering the rapid advances in both rare cell isolation and low-input DNA analysis, we argue here that CFC-based noninvasive prenatal testing is poised to be implemented clinically in the near future.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/134092