The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments

Kim, JH; Nguyen, DT; Booth, JT; Huang, CY; Fuangrod, T; Poulsen, P; O'Brien, R; Caillet, V; Eade, T; Kneebone, A; Keall, P

The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments

Kim, JH Nguyen, DT

Booth, JT Huang, CY Fuangrod, T Poulsen, P O'Brien, R Caillet, V Eade, T Kneebone, A Keall, P

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Publication Type:: Journal Article
Citation:: Radiotherapy and Oncology, 2018, 126 (2), pp. 236 - 243
Issue Date:: 2018-02-01

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Field	Value	Language
dc.contributor.author	Kim, JH	en_US
dc.contributor.author	Nguyen, DT https://orcid.org/0000-0003-1581-0359	en_US
dc.contributor.author	Booth, JT	en_US
dc.contributor.author	Huang, CY	en_US
dc.contributor.author	Fuangrod, T	en_US
dc.contributor.author	Poulsen, P	en_US
dc.contributor.author	O'Brien, R	en_US
dc.contributor.author	Caillet, V	en_US
dc.contributor.author	Eade, T	en_US
dc.contributor.author	Kneebone, A	en_US
dc.contributor.author	Keall, P	en_US
dc.date.available	2017-10-22	en_US
dc.date.issued	2018-02-01	en_US
dc.identifier.citation	Radiotherapy and Oncology, 2018, 126 (2), pp. 236 - 243	en_US
dc.identifier.issn	0167-8140	en_US
dc.identifier.uri	http://hdl.handle.net/10453/134130
dc.description.abstract	© 2017 Elsevier B.V. Background and purpose: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. Material and methods: Real-time 6DoF prostate motion was acquired using KIM for 14 prostate cancer patients (377 fractions). KIM outputs the 6DoF prostate motion, combining 3D translation and 3D rotational motion information relative to its planning position. The corresponding groundtruth target motion was obtained post-treatment based on kV/MV triangulation. The accuracy and precision of the 6DoF KIM motion estimates were calculated as the mean and standard deviation differences compared with the ground-truth. Results: The accuracy ± precision of real-time 6DoF KIM−measured prostate motion were 0.2 ± 1.3° for rotations and 0.1 ± 0.5 mm for translations, respectively. The magnitude of KIM-measured motion was well-correlated with the magnitude of ground-truth motion resulting in Pearson correlation coefficients of ≥0.88 in all DoF. Conclusions: The results demonstrate that KIM is capable of providing the real-time 6DoF prostate target motion during patient treatments with an accuracy ± precision of within 0.2 ± 1.3° and 0.1 ± 0.5 mm for rotation and translation, respectively. As KIM only requires a single X-ray imager, which is available on most modern cancer radiotherapy devices, there is potential for widespread adoption of this technology.	en_US
dc.relation.ispartof	Radiotherapy and Oncology	en_US
dc.relation.isbasedon	10.1016/j.radonc.2017.10.030	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Prostatic Neoplasms	en_US
dc.subject.mesh	Radiotherapy Planning, Computer-Assisted	en_US
dc.subject.mesh	Movement	en_US
dc.subject.mesh	Algorithms	en_US
dc.subject.mesh	Rotation	en_US
dc.subject.mesh	Computer Systems	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Radiotherapy, Image-Guided	en_US
dc.subject.mesh	Dose Fractionation, Radiation	en_US
dc.title	The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	126	en_US
utslib.for	0299 Other Physical Sciences	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	126	en_US

Abstract:

© 2017 Elsevier B.V. Background and purpose: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. Material and methods: Real-time 6DoF prostate motion was acquired using KIM for 14 prostate cancer patients (377 fractions). KIM outputs the 6DoF prostate motion, combining 3D translation and 3D rotational motion information relative to its planning position. The corresponding groundtruth target motion was obtained post-treatment based on kV/MV triangulation. The accuracy and precision of the 6DoF KIM motion estimates were calculated as the mean and standard deviation differences compared with the ground-truth. Results: The accuracy ± precision of real-time 6DoF KIM−measured prostate motion were 0.2 ± 1.3° for rotations and 0.1 ± 0.5 mm for translations, respectively. The magnitude of KIM-measured motion was well-correlated with the magnitude of ground-truth motion resulting in Pearson correlation coefficients of ≥0.88 in all DoF. Conclusions: The results demonstrate that KIM is capable of providing the real-time 6DoF prostate target motion during patient treatments with an accuracy ± precision of within 0.2 ± 1.3° and 0.1 ± 0.5 mm for rotation and translation, respectively. As KIM only requires a single X-ray imager, which is available on most modern cancer radiotherapy devices, there is potential for widespread adoption of this technology.

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http://hdl.handle.net/10453/134130