Molecular insights on the interference of simplified lung surfactant models by gold nanoparticle pollutants

Hossain, SI; Gandhi, NS; Hughes, ZE; Gu, YT; Saha, SC

Molecular insights on the interference of simplified lung surfactant models by gold nanoparticle pollutants

Hossain, SI

Gandhi, NS Hughes, ZE Gu, YT Saha, SC

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Publication Type:: Journal Article
Citation:: Biochimica et Biophysica Acta - Biomembranes, 2019, 1861 (8), pp. 1458 - 1467
Issue Date:: 2019-08-01

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Field	Value	Language
dc.contributor.author	Hossain, SI https://orcid.org/0000-0003-1951-4602	en_US
dc.contributor.author	Gandhi, NS	en_US
dc.contributor.author	Hughes, ZE	en_US
dc.contributor.author	Gu, YT	en_US
dc.contributor.author	Saha, SC https://orcid.org/0000-0002-9962-8919	en_US
dc.date.available	2020-06-01T19:08:36Z
dc.date.issued	2019-08-01	en_US
dc.identifier.citation	Biochimica et Biophysica Acta - Biomembranes, 2019, 1861 (8), pp. 1458 - 1467	en_US
dc.identifier.issn	0005-2736	en_US
dc.identifier.uri	http://hdl.handle.net/10453/134156
dc.description.abstract	© 2019 Elsevier B.V. Inhaled nanoparticles (NPs) are experienced by the first biological barrier inside the alveolus known as lung surfactant (LS), a surface tension reducing agent, consisting of phospholipids and proteins in the form of the monolayer at the air-water interface. The monolayer surface tension is continuously regulated by the alveolus compression and expansion and protects the alveoli from collapsing. Inhaled NPs can reach deep into the lungs and interfere with the biophysical properties of the lung components. The interaction mechanisms of bare gold nanoparticles (AuNPs) with the LS monolayer and the consequences of the interactions on lung function are not well understood. Coarse-grained molecular dynamics simulations were carried out to elucidate the interactions of AuNPs with simplified LS monolayers at the nanoscale. It was observed that the interactions of AuNPs and LS components deform the monolayer structure, change the biophysical properties of LS and create pores in the monolayer, which all interfere with the normal lungs function. The results also indicate that AuNP concentrations >0.1 mol% (of AuNPs/lipids) hinder the lowering of the LS surface tension, a prerequisite of the normal breathing process. Overall, these findings could help to identify the possible consequences of airborne NPs inhalation and their contribution to the potential development of various lung diseases.	en_US
dc.relation.ispartof	Biochimica et Biophysica Acta - Biomembranes	en_US
dc.relation.isbasedon	10.1016/j.bbamem.2019.06.001	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Biophysics	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Pulmonary Alveoli	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Gold	en_US
dc.subject.mesh	Pulmonary Surfactants	en_US
dc.subject.mesh	Air Pollutants	en_US
dc.subject.mesh	Phase Transition	en_US
dc.subject.mesh	Surface Tension	en_US
dc.subject.mesh	Metal Nanoparticles	en_US
dc.subject.mesh	Molecular Dynamics Simulation	en_US
dc.title	Molecular insights on the interference of simplified lung surfactant models by gold nanoparticle pollutants	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	1861	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0699 Other Biological Sciences	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access	*
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	1861	en_US

Abstract:

© 2019 Elsevier B.V. Inhaled nanoparticles (NPs) are experienced by the first biological barrier inside the alveolus known as lung surfactant (LS), a surface tension reducing agent, consisting of phospholipids and proteins in the form of the monolayer at the air-water interface. The monolayer surface tension is continuously regulated by the alveolus compression and expansion and protects the alveoli from collapsing. Inhaled NPs can reach deep into the lungs and interfere with the biophysical properties of the lung components. The interaction mechanisms of bare gold nanoparticles (AuNPs) with the LS monolayer and the consequences of the interactions on lung function are not well understood. Coarse-grained molecular dynamics simulations were carried out to elucidate the interactions of AuNPs with simplified LS monolayers at the nanoscale. It was observed that the interactions of AuNPs and LS components deform the monolayer structure, change the biophysical properties of LS and create pores in the monolayer, which all interfere with the normal lungs function. The results also indicate that AuNP concentrations >0.1 mol% (of AuNPs/lipids) hinder the lowering of the LS surface tension, a prerequisite of the normal breathing process. Overall, these findings could help to identify the possible consequences of airborne NPs inhalation and their contribution to the potential development of various lung diseases.

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http://hdl.handle.net/10453/134156