Aerosol particle transport and deposition in a CT-scan based mouth-throat model

Saha, SC; Islam, MS; Rahimi-Gorji, M; Molla, MM

Aerosol particle transport and deposition in a CT-scan based mouth-throat model

Saha, SC

Islam, MS Rahimi-Gorji, M Molla, MM

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Publication Type:: Conference Proceeding
Citation:: AIP Conference Proceedings, 2019, 2121
Issue Date:: 2019-07-18

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Field	Value	Language
dc.contributor.author	Saha, SC https://orcid.org/0000-0002-9962-8919	en_US
dc.contributor.author	Islam, MS	en_US
dc.contributor.author	Rahimi-Gorji, M	en_US
dc.contributor.author	Molla, MM	en_US
dc.date.available	2020-07-18T19:13:01Z
dc.date.issued	2019-07-18	en_US
dc.identifier.citation	AIP Conference Proceedings, 2019, 2121	en_US
dc.identifier.isbn	9780735418615	en_US
dc.identifier.issn	0094-243X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/135250
dc.description.abstract	© 2019 Author(s). A precise understanding of the aerosol particle transport and deposition (TD) in the realistic mouth-throat model is important for the respiratory health risk assessment and effective delivery of the aerosol medicine to the targeted positions of the lung. A wide range of studies have developed the particle TD framework for both idealized and non-idealized extra-thoracic airways. However, all of the existing in silico and experimental model reports a significant amount of aerosol particles are deposit at the extra-thoracic airways and the existing drug delivery device can deliver only 12 percent of the aerosol drug to the targeted position of the lung. This study aims to increase the efficiency of the targeted drug delivery by developing a realistic particle transport model for CT-Scan based mouth-throat replica. A 3-D realistic mouth-throat model is developed from the CT-Scan DiCom images of a healthy adult cast. High-Quality computational cells are generated for the replica model and the proper grid refinement test has been performed. ANSYS Fluent (19.1) solver is used for the particle TD computation. Tecplot and MATLAB software are used for the post-processing purpose. The numerical results report that the breathing pattern and particle diameter influences the overall particle TD in the mouth-throat model. The numerical results also depict different deposition hot spots for the mouth-throat model, which will eventually help to design a better drug delivery device. The numerical results reported that only 13.67 percent of the 10-μm diameter particles are deposited at the mouth-throat model at 15 lpm flow rate and which indicate that the remaining particles will move to the beyond airways. The present results along with more case studies will develop the understanding of the realistic particle deposition in the extrathoracic airways.	en_US
dc.relation.ispartof	AIP Conference Proceedings	en_US
dc.relation.isbasedon	10.1063/1.5115882	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Aerosol particle transport and deposition in a CT-scan based mouth-throat model	en_US
dc.type	Conference Proceeding
utslib.citation.volume	2121	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
pubs.publication-status	Published	en_US
pubs.volume	2121	en_US

Abstract:

© 2019 Author(s). A precise understanding of the aerosol particle transport and deposition (TD) in the realistic mouth-throat model is important for the respiratory health risk assessment and effective delivery of the aerosol medicine to the targeted positions of the lung. A wide range of studies have developed the particle TD framework for both idealized and non-idealized extra-thoracic airways. However, all of the existing in silico and experimental model reports a significant amount of aerosol particles are deposit at the extra-thoracic airways and the existing drug delivery device can deliver only 12 percent of the aerosol drug to the targeted position of the lung. This study aims to increase the efficiency of the targeted drug delivery by developing a realistic particle transport model for CT-Scan based mouth-throat replica. A 3-D realistic mouth-throat model is developed from the CT-Scan DiCom images of a healthy adult cast. High-Quality computational cells are generated for the replica model and the proper grid refinement test has been performed. ANSYS Fluent (19.1) solver is used for the particle TD computation. Tecplot and MATLAB software are used for the post-processing purpose. The numerical results report that the breathing pattern and particle diameter influences the overall particle TD in the mouth-throat model. The numerical results also depict different deposition hot spots for the mouth-throat model, which will eventually help to design a better drug delivery device. The numerical results reported that only 13.67 percent of the 10-μm diameter particles are deposited at the mouth-throat model at 15 lpm flow rate and which indicate that the remaining particles will move to the beyond airways. The present results along with more case studies will develop the understanding of the realistic particle deposition in the extrathoracic airways.

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http://hdl.handle.net/10453/135250