Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system

Karacan, I; Ben-Nissan, B; Wang, HA; Juritza, A; Swain, MV; Müller, WH; Chou, J; Stamboulis, A; Macha, IJ; Taraschi, V

Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system

Karacan, I Ben-Nissan, B Wang, HA Juritza, A Swain, MV Müller, WH Chou, J

Stamboulis, A Macha, IJ Taraschi, V

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Publication Type:: Journal Article
Citation:: Materials Science and Engineering C, 2019, 104
Issue Date:: 2019-11-01

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Field	Value	Language
dc.contributor.author	Karacan, I	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Wang, HA	en_US
dc.contributor.author	Juritza, A	en_US
dc.contributor.author	Swain, MV	en_US
dc.contributor.author	Müller, WH	en_US
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Stamboulis, A	en_US
dc.contributor.author	Macha, IJ	en_US
dc.contributor.author	Taraschi, V	en_US
dc.date.available	2019-05-14	en_US
dc.date.issued	2019-11-01	en_US
dc.identifier.citation	Materials Science and Engineering C, 2019, 104	en_US
dc.identifier.issn	0928-4931	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136052
dc.description.abstract	© 2019 Elsevier B.V. Post-operative infection often occurs following orthopedic and dental implant placement requiring systemically administered antibiotics. However, this does not provide long-term protection. Over the last few decades, alternative methods involving slow drug delivery systems based on biodegradable poly-lactic acid and antibiotic loaded hydroxyapatite microspheres were developed to prevent post-operative infection. In this study, thermally anodised and untreated Ti6Al4V discs were coated with Poly-Lactic Acid (PLA) containing Gentamicin (Gm) antibiotic-loaded coralline Hydroxyapatite (HAp) are investigated. Following chemical characterization, mechanical properties of the coated samples were measured using nanoindentation and scratch tests to determine the elastic modulus, hardness and bonding adhesion between film and substrate. It was found that PLA biocomposite multilayered films were around 400 nm thick and the influence and effect of the substrate were clearly observed during the nanoindentation studies with heavier loads. Scratch tests of PLA coated samples conducted at ~160 nm depth showed the minimal difference in the measured friction between Gm and non Gm containing films. It is also observed that the hardness values of PLA film coated anodised samples ranged from 0.45 to 1.9 GPa (dependent on the applied loads) against untreated coated samples which ranged from 0.28 to 0.8 GPa.	en_US
dc.relation.ispartof	Materials Science and Engineering C	en_US
dc.relation.isbasedon	10.1016/j.msec.2019.109757	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biomedical Engineering	en_US
dc.subject.mesh	Titanium	en_US
dc.subject.mesh	Metals	en_US
dc.subject.mesh	Polyesters	en_US
dc.subject.mesh	Coated Materials, Biocompatible	en_US
dc.subject.mesh	Anti-Infective Agents	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Spectroscopy, Fourier Transform Infrared	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Materials Testing	en_US
dc.subject.mesh	Prostheses and Implants	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.title	Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system	en_US
dc.type	Journal Article
utslib.citation.volume	104	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0912 Materials Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.publication-status	Published	en_US
pubs.volume	104	en_US

Abstract:

© 2019 Elsevier B.V. Post-operative infection often occurs following orthopedic and dental implant placement requiring systemically administered antibiotics. However, this does not provide long-term protection. Over the last few decades, alternative methods involving slow drug delivery systems based on biodegradable poly-lactic acid and antibiotic loaded hydroxyapatite microspheres were developed to prevent post-operative infection. In this study, thermally anodised and untreated Ti6Al4V discs were coated with Poly-Lactic Acid (PLA) containing Gentamicin (Gm) antibiotic-loaded coralline Hydroxyapatite (HAp) are investigated. Following chemical characterization, mechanical properties of the coated samples were measured using nanoindentation and scratch tests to determine the elastic modulus, hardness and bonding adhesion between film and substrate. It was found that PLA biocomposite multilayered films were around 400 nm thick and the influence and effect of the substrate were clearly observed during the nanoindentation studies with heavier loads. Scratch tests of PLA coated samples conducted at ~160 nm depth showed the minimal difference in the measured friction between Gm and non Gm containing films. It is also observed that the hardness values of PLA film coated anodised samples ranged from 0.45 to 1.9 GPa (dependent on the applied loads) against untreated coated samples which ranged from 0.28 to 0.8 GPa.

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http://hdl.handle.net/10453/136052