Association between carotid intima-media thickness and bone mineral density: A cross-sectional study in Vietnamese men and women aged 50 years and older

Nguyen, LT; Pham, VN; Chau, PMN; Ho-Pham, LT; Nguyen, TV

Association between carotid intima-media thickness and bone mineral density: A cross-sectional study in Vietnamese men and women aged 50 years and older

Nguyen, LT Pham, VN Chau, PMN Ho-Pham, LT Nguyen, TV

Permalink

Publication Type:: Journal Article
Citation:: BMJ Open, 2019, 9 (9)
Issue Date:: 2019-09-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published VersionAdobe PDF (668.45 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Nguyen, LT	en_US
dc.contributor.author	Pham, VN	en_US
dc.contributor.author	Chau, PMN	en_US
dc.contributor.author	Ho-Pham, LT	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.issued	2019-09-01	en_US
dc.identifier.citation	BMJ Open, 2019, 9 (9)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136269
dc.description.abstract	© 2019 Author(s). Objectives The association between osteoporosis and atherosclerosis remains controversial. We sought to define the relationship between carotid intima-media thickness and bone mineral density (BMD) in individuals of Vietnamese background. Design and setting Cross-sectional study in Ho Chi Minh City, Vietnam. Participants The study involved 1460 individuals (559 men) aged 50 years and older (average age 59 years) who were randomly recruited from the community. Outcome measures BMD at the femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (Hologic, Waltham, Massachusetts, USA). Carotid intima-media thickness (cIMT) was measured using a Philips Ultrasonography (HD7XE). The presence of atherosclerotic plaque was ascertained for each individual. The association between cIMT and BMD was analysed by a multiple linear regression model. Results In unadjusted analysis, cIMT was positively associated with femoral neck BMD in men (p=0.005), but not in women (p=0.242). After adjusting for age, smoking, diabetes and hypertension, the association remained statistically significant in men (partial R 2 =0.005; p=0.015) but not in women (partial R 2 =0.008; p=0.369). When the analysis was limited to individuals aged 60 years and older, the association between cIMT and BMD was no longer statistically significant. There was no statistically significant association between cIMT and lumbar spine BMD in either men or women. Conclusions In Vietnamese individuals aged 50 years and older, there is a clinically non-significant but statistically significant association between carotid intima-media thickness and BMD in men, not in women.	en_US
dc.relation.ispartof	BMJ Open	en_US
dc.relation.isbasedon	10.1136/bmjopen-2018-028603	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Association between carotid intima-media thickness and bone mineral density: A cross-sectional study in Vietnamese men and women aged 50 years and older	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1199 Other Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

© 2019 Author(s). Objectives The association between osteoporosis and atherosclerosis remains controversial. We sought to define the relationship between carotid intima-media thickness and bone mineral density (BMD) in individuals of Vietnamese background. Design and setting Cross-sectional study in Ho Chi Minh City, Vietnam. Participants The study involved 1460 individuals (559 men) aged 50 years and older (average age 59 years) who were randomly recruited from the community. Outcome measures BMD at the femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (Hologic, Waltham, Massachusetts, USA). Carotid intima-media thickness (cIMT) was measured using a Philips Ultrasonography (HD7XE). The presence of atherosclerotic plaque was ascertained for each individual. The association between cIMT and BMD was analysed by a multiple linear regression model. Results In unadjusted analysis, cIMT was positively associated with femoral neck BMD in men (p=0.005), but not in women (p=0.242). After adjusting for age, smoking, diabetes and hypertension, the association remained statistically significant in men (partial R 2 =0.005; p=0.015) but not in women (partial R 2 =0.008; p=0.369). When the analysis was limited to individuals aged 60 years and older, the association between cIMT and BMD was no longer statistically significant. There was no statistically significant association between cIMT and lumbar spine BMD in either men or women. Conclusions In Vietnamese individuals aged 50 years and older, there is a clinically non-significant but statistically significant association between carotid intima-media thickness and BMD in men, not in women.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/136269