Ultrafine particle transport and deposition in the upper airways of a CT-based realistic lung

Saha, SC; Islam, MS; Luo, Z

Ultrafine particle transport and deposition in the upper airways of a CT-based realistic lung

Saha, SC

Islam, MS Luo, Z

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Publication Type:: Conference Proceeding
Citation:: Proceedings of the 21st Australasian Fluid Mechanics Conference, AFMC 2018, 2018
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Saha, SC https://orcid.org/0000-0002-9962-8919	en_US
dc.contributor.author	Islam, MS	en_US
dc.contributor.author	Luo, Z https://orcid.org/0000-0002-6953-3986	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Proceedings of the 21st Australasian Fluid Mechanics Conference, AFMC 2018, 2018	en_US
dc.identifier.isbn	9780646597843	en_US
dc.identifier.uri	http://hdl.handle.net/10453/137955
dc.description.abstract	© 2018 Australasian Fluid Mechanics Society. All rights reserved. The understanding of the toxic pollutant particles transport and deposition is important for dosimetry and respiratory health effects analysis. The studies over the last few decades for ultrafine particle transport and deposition improves the understanding of the drug-aerosol impacts in the extrathoracic airways. A limited number of studies has also considered upper airways and almost all of those studies used the non-realistic smooth surface for upper airway model. However, the smooth surface anatomical model is far from the realistic lung and it is important to consider realistic lung model for better prediction of ultrafine particle deposition. This study aims to simulate the ultrafine particle transport and deposition in the upper airways of a highly asymmetric CT-based model. The anatomically explicit digital airway model is generated from the high-resolution CT data of a healthy adult. Unstructured tetrahedral mesh throughout the geometry and fine inflation layer mesh near the wall is generated. Euler-Lagrange (E-L) approach and ANSYS Fluent solver (18.2) are used to investigate the ultrafine particle transport and deposition. A wide range of diameter (1 ≤ nm ≤ 1000) and different flow rates are considered for the ultrafine particle simulation. Pressure drop is calculated for right and left lobes which might be helpful for the therapeutic purpose of the asthma patient. The numerical study shows that the deposition efficiency in the right lung and the left lung is different for dissimilar flow rates, which could help the health risk assessment of the respiratory diseases and eventually could help the targeted drug delivery system.	en_US
dc.relation.ispartof	Proceedings of the 21st Australasian Fluid Mechanics Conference, AFMC 2018	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Ultrafine particle transport and deposition in the upper airways of a CT-based realistic lung	en_US
dc.type	Conference Proceeding
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
pubs.publication-status	Published	en_US

Abstract:

© 2018 Australasian Fluid Mechanics Society. All rights reserved. The understanding of the toxic pollutant particles transport and deposition is important for dosimetry and respiratory health effects analysis. The studies over the last few decades for ultrafine particle transport and deposition improves the understanding of the drug-aerosol impacts in the extrathoracic airways. A limited number of studies has also considered upper airways and almost all of those studies used the non-realistic smooth surface for upper airway model. However, the smooth surface anatomical model is far from the realistic lung and it is important to consider realistic lung model for better prediction of ultrafine particle deposition. This study aims to simulate the ultrafine particle transport and deposition in the upper airways of a highly asymmetric CT-based model. The anatomically explicit digital airway model is generated from the high-resolution CT data of a healthy adult. Unstructured tetrahedral mesh throughout the geometry and fine inflation layer mesh near the wall is generated. Euler-Lagrange (E-L) approach and ANSYS Fluent solver (18.2) are used to investigate the ultrafine particle transport and deposition. A wide range of diameter (1 ≤ nm ≤ 1000) and different flow rates are considered for the ultrafine particle simulation. Pressure drop is calculated for right and left lobes which might be helpful for the therapeutic purpose of the asthma patient. The numerical study shows that the deposition efficiency in the right lung and the left lung is different for dissimilar flow rates, which could help the health risk assessment of the respiratory diseases and eventually could help the targeted drug delivery system.

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http://hdl.handle.net/10453/137955