Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

Shrestha, J; Razavi Bazaz, S; Aboulkheyr Es, H; Yaghobian Azari, D; Thierry, B; Ebrahimi Warkiani, M; Ghadiri, M

Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

Shrestha, J Razavi Bazaz, S

Aboulkheyr Es, H Yaghobian Azari, D Thierry, B Ebrahimi Warkiani, M

Ghadiri, M

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Publication Type:: Journal Article
Citation:: Critical Reviews in Biotechnology, 2020, 40 (2), pp. 213 - 230
Issue Date:: 2020-02-17

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Field	Value	Language
dc.contributor.author	Shrestha, J	en_US
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361	en_US
dc.contributor.author	Aboulkheyr Es, H	en_US
dc.contributor.author	Yaghobian Azari, D	en_US
dc.contributor.author	Thierry, B	en_US
dc.contributor.author	Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944	en_US
dc.contributor.author	Ghadiri, M https://orcid.org/0000-0002-7371-9505	en_US
dc.date.available	2021-01-06T18:05:25Z
dc.date.issued	2020-02-17	en_US
dc.identifier.citation	Critical Reviews in Biotechnology, 2020, 40 (2), pp. 213 - 230	en_US
dc.identifier.issn	0738-8551	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138231
dc.description.abstract	© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Recently, organ-on-a-chip models, which are microfluidic devices that mimic the cellular architecture and physiological environment of an organ, have been developed and extensively investigated. The chips can be tailored to accommodate the disease conditions pertaining to many organs; and in the case of this review, the lung. Lung-on-a-chip models result in a more accurate reflection compared to conventional in vitro models. Pharmaceutical drug testing methods traditionally use animal models in order to evaluate pharmacological and toxicological responses to a new agent. However, these responses do not directly reflect human physiological responses. In this review, current and future applications of the lung-on-a-chip in the respiratory system will be discussed. Furthermore, the limitations of current conventional in vitro models used for respiratory disease modeling and drug development will be addressed. Highlights of additional translational aspects of the lung-on-a-chip will be discussed in order to demonstrate the importance of this subject for medical research.	en_US
dc.relation.ispartof	Critical Reviews in Biotechnology	en_US
dc.relation.isbasedon	10.1080/07388551.2019.1710458	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biotechnology	en_US
dc.title	Lung-on-a-chip: the future of respiratory disease models and pharmacological studies	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	40	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	10 Technology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	40	en_US

Abstract:

© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Recently, organ-on-a-chip models, which are microfluidic devices that mimic the cellular architecture and physiological environment of an organ, have been developed and extensively investigated. The chips can be tailored to accommodate the disease conditions pertaining to many organs; and in the case of this review, the lung. Lung-on-a-chip models result in a more accurate reflection compared to conventional in vitro models. Pharmaceutical drug testing methods traditionally use animal models in order to evaluate pharmacological and toxicological responses to a new agent. However, these responses do not directly reflect human physiological responses. In this review, current and future applications of the lung-on-a-chip in the respiratory system will be discussed. Furthermore, the limitations of current conventional in vitro models used for respiratory disease modeling and drug development will be addressed. Highlights of additional translational aspects of the lung-on-a-chip will be discussed in order to demonstrate the importance of this subject for medical research.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/138231