Implantable Biosensor Interface Platform for Monitoring of Atherosclerosis

Al-Zubi, M; Sanagavarapu, A

Implantable Biosensor Interface Platform for Monitoring of Atherosclerosis

Al-Zubi, M

Sanagavarapu, A

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Publisher:: Institute of Electrical and Electronics Engineers
Publication Type:: Journal Article
Citation:: IEEE Sensors Letters, 2020
Issue Date:: 2020-01-22

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Field	Value	Language
dc.contributor.author	Al-Zubi, M https://orcid.org/0000-0002-4792-7386	en_US
dc.contributor.author	Sanagavarapu, A https://orcid.org/0000-0002-4503-5851	en_US
dc.date.issued	2020-01-22	en_US
dc.identifier.citation	IEEE Sensors Letters, 2020	en_US
dc.identifier.issn	2475-1472	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138308
dc.description.abstract	The drug-eluting stents (DESs) have been considered as an effective technique to reduce the severity of atherosclerotic stenosis. Recent technological advances have opened the door for developing new and innovative smart cardiovascular stents by integrating various electronics components and sensors to improve health monitoring and diagnosis. Rupture of atherosclerotic plaque represents the major cause of cardiovascular disease (CVD) such as heart attacks due to blockages of the arterial lumen. Pentraxin-3 (PTX3) is a novel localized inflammatory biomarker associated with the development of atherosclerosis and plaque vulnerability. In this paper, we propose a biosensor interface platform for monitoring the plaque vulnerability via detection and prediction of the inflammatory biomarker (PTX3). We propose mathematical and stochastic models using molecular communication paradigm for detection of Pentraxin-3 (PTX3) molecules in the atherosclerotic arterial wall using biosensor attached to a vascular stent inside the artery. The proposed platform and models can help in the localized sensing of the atherosclerotic biomarkers for monitoring of the plaque progression and for early warning of certain disorders such as heart attack.	en_US
dc.publisher	Institute of Electrical and Electronics Engineers	en_US
dc.relation.ispartof	IEEE Sensors Letters	en_US
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.title	Implantable Biosensor Interface Platform for Monitoring of Atherosclerosis	en_US
dc.type	Journal Article
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
pubs.consider-herdc	false	en_US
utslib.copyright.embargo	2022-01-22T00:00:00+1100

Abstract:

The drug-eluting stents (DESs) have been considered as an effective technique to reduce the severity of atherosclerotic stenosis. Recent technological advances have opened the door for developing new and innovative smart cardiovascular stents by integrating various electronics components and sensors to improve health monitoring and diagnosis. Rupture of atherosclerotic plaque represents the major cause of cardiovascular disease (CVD) such as heart attacks due to blockages of the arterial lumen. Pentraxin-3 (PTX3) is a novel localized inflammatory biomarker associated with the development of atherosclerosis and plaque vulnerability. In this paper, we propose a biosensor interface platform for monitoring the plaque vulnerability via detection and prediction of the inflammatory biomarker (PTX3). We propose mathematical and stochastic models using molecular communication paradigm for detection of Pentraxin-3 (PTX3) molecules in the atherosclerotic arterial wall using biosensor attached to a vascular stent inside the artery. The proposed platform and models can help in the localized sensing of the atherosclerotic biomarkers for monitoring of the plaque progression and for early warning of certain disorders such as heart attack.

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http://hdl.handle.net/10453/138308