Modelling the deformation behavior of stomatocyte, discocyte and echinocyte red blood cell morphologies during optical tweezers stretching

Geekiyanage, N; Sauret, E; Saha, S; Flower, R; Gu, Y

Modelling the deformation behavior of stomatocyte, discocyte and echinocyte red blood cell morphologies during optical tweezers stretching

Geekiyanage, N Sauret, E Saha, S

Flower, R Gu, Y

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Publication Type:: Conference Proceeding
Citation:: 6th International Conference on Computational and Mathematical Biomedical Engineering – CMBE2019, 2019
Issue Date:: 2019-06-10

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Field	Value	Language
dc.contributor.author	Geekiyanage, N	en_US
dc.contributor.author	Sauret, E	en_US
dc.contributor.author	Saha, S https://orcid.org/0000-0002-9962-8919	en_US
dc.contributor.author	Flower, R	en_US
dc.contributor.author	Gu, Y	en_US
dc.contributor.editor	Nithiarasu, P	en_US
dc.contributor.editor	Ohta, M	en_US
dc.contributor.editor	Oshima, M	en_US
dc.date	2019-06-10	en_US
dc.date.issued	2019-06-10	en_US
dc.identifier.citation	6th International Conference on Computational and Mathematical Biomedical Engineering – CMBE2019, 2019	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138372
dc.description.abstract	A coarse-grained (CG) red blood cell (RBC) membrane model is used to investigate the deformation behavior of stomatocyte, discocyte and echinocyte morphologies during optical tweezers stretching. First, the numerically predicted discocyte deformation behavior is validated against analogous experimental observations, and then the numerically predicted stomatocyte and echinocyte deformation behavior is compared to the discocyte deformation behavior. The findings indicate that the CG-RBC membrane model is capable of accurately predicting the deformation behavior of stomatocyte, discocyte and echinocyte RBC morphologies during optical tweezers stretching, and an applicable tool to investigate the evolution of RBC behavior and membrane properties for different morphologies.	en_US
dc.relation	http://purl.org/au-research/grants/arc/LP150100737
dc.relation.ispartof	6th International Conference on Computational and Mathematical Biomedical Engineering – CMBE2019	en_US
dc.relation.ispartof	International Conference on Computational and Mathematical Biomedical Engineering	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Modelling the deformation behavior of stomatocyte, discocyte and echinocyte red blood cell morphologies during optical tweezers stretching	en_US
dc.type	Conference Proceeding
utslib.location.activity	Japan	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
pubs.consider-herdc	true	en_US
pubs.finish-date	2019-06-12	en_US
pubs.publication-status	Published	en_US
pubs.start-date	2019-06-10	en_US

Abstract:

A coarse-grained (CG) red blood cell (RBC) membrane model is used to investigate the deformation behavior of stomatocyte, discocyte and echinocyte morphologies during optical tweezers stretching. First, the numerically predicted discocyte deformation behavior is validated against analogous experimental observations, and then the numerically predicted stomatocyte and echinocyte deformation behavior is compared to the discocyte deformation behavior. The findings indicate that the CG-RBC membrane model is capable of accurately predicting the deformation behavior of stomatocyte, discocyte and echinocyte RBC morphologies during optical tweezers stretching, and an applicable tool to investigate the evolution of RBC behavior and membrane properties for different morphologies.

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http://hdl.handle.net/10453/138372