Modelling the deformation behavior of stomatocyte, discocyte and echinocyte red blood cell morphologies during optical tweezers stretching
- Publication Type:
- Conference Proceeding
- Citation:
- 6th International Conference on Computational and Mathematical Biomedical Engineering – CMBE2019, 2019
- Issue Date:
- 2019-06-10
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A coarse-grained (CG) red blood cell (RBC) membrane model is used to investigate the deformation behavior of stomatocyte, discocyte and echinocyte morphologies during optical tweezers stretching. First, the numerically predicted discocyte deformation behavior is validated against analogous experimental observations, and then the numerically predicted stomatocyte and echinocyte deformation behavior is compared to the discocyte deformation behavior. The findings indicate that the CG-RBC membrane model is capable of accurately predicting the deformation behavior of stomatocyte, discocyte and echinocyte RBC morphologies during optical tweezers stretching, and an applicable tool to investigate the evolution of RBC behavior and membrane properties for different morphologies.
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