Euler–Lagrange approach to investigate respiratory anatomical shape effects on aerosol particle transport and deposition

Islam, MS; Saha, SC; Sauret, E; Ong, H; Young, P; Gu, YT

Euler–Lagrange approach to investigate respiratory anatomical shape effects on aerosol particle transport and deposition

Islam, MS

Saha, SC

Sauret, E Ong, H Young, P Gu, YT

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Publisher:: SAGE Publications
Publication Type:: Journal Article
Citation:: Toxicology Research and Application, 2019, 3 pp. 239784731989467 - 239784731989467
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Islam, MS https://orcid.org/0000-0001-6264-3886	en_US
dc.contributor.author	Saha, SC https://orcid.org/0000-0002-9962-8919	en_US
dc.contributor.author	Sauret, E	en_US
dc.contributor.author	Ong, H	en_US
dc.contributor.author	Young, P	en_US
dc.contributor.author	Gu, YT	en_US
dc.date.accessioned	2020-03-22T02:16:14Z
dc.date.available	2020-03-22T02:16:14Z
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Toxicology Research and Application, 2019, 3 pp. 239784731989467 - 239784731989467	en_US
dc.identifier.issn	2397-8473	en_US
dc.identifier.uri	http://hdl.handle.net/10453/139461
dc.description.abstract	<jats:p> An accurate knowledge of the pulmonary aerosol particle transport in the realistic lung is essential to deliver the therapeutic particle to the targeted site of the bifurcating airways. The available in silico studies have enriched the knowledge of the aerosol transport and deposition (TD) in the lung; however, the absolute TD data in the realistic lung airway are still elusive. Therefore, in this study, a 3-D geometry of the human lung central airway is developed from the computed tomography (CT) images. A CT scan-based modified lung geometry with a smooth surface and nonrealistic Weibel’s lung geometry is also generated. The coal mine exhausted aerosol TD in the upper airway is investigated. The Euler–Lagrange (E-L) method for particle tracking and ANSYS Fluent solver are used to carry out the entire investigation. The effective diameter method is employed to define the shape-specific particles and is integrated with the E-L method. The anatomical shape effects on the deposition patterns are investigated for different deposition parameter. The numerical results illustrated that the airway geometry, particle shape, particle diameter, and breathing flow rates significantly influence the aerosol TD pattern in the upper airway. The present study reports that airway tracheal wall is the new deposition hot spot for the CT-based geometry instead of bifurcating area for the idealized model, which might be helpful for zone-specific drug delivery to the respiratory airways. </jats:p>	en_US
dc.language	en	en_US
dc.publisher	SAGE Publications	en_US
dc.relation.ispartof	Toxicology Research and Application	en_US
dc.relation.isbasedon	10.1177/2397847319894675	en_US
dc.rights	Toxicology Research and Application, 2019, 3 pp. 239784731989467 - 239784731989467. Copyright © 2019 SAGE Publications. DOI: https://dx.doi.org/10.1177/2397847319894675	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Euler–Lagrange approach to investigate respiratory anatomical shape effects on aerosol particle transport and deposition	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
pubs.publication-status	Published	en_US
pubs.volume	3	en_US

Abstract:

An accurate knowledge of the pulmonary aerosol particle transport in the realistic lung is essential to deliver the therapeutic particle to the targeted site of the bifurcating airways. The available in silico studies have enriched the knowledge of the aerosol transport and deposition (TD) in the lung; however, the absolute TD data in the realistic lung airway are still elusive. Therefore, in this study, a 3-D geometry of the human lung central airway is developed from the computed tomography (CT) images. A CT scan-based modified lung geometry with a smooth surface and nonrealistic Weibel’s lung geometry is also generated. The coal mine exhausted aerosol TD in the upper airway is investigated. The Euler–Lagrange (E-L) method for particle tracking and ANSYS Fluent solver are used to carry out the entire investigation. The effective diameter method is employed to define the shape-specific particles and is integrated with the E-L method. The anatomical shape effects on the deposition patterns are investigated for different deposition parameter. The numerical results illustrated that the airway geometry, particle shape, particle diameter, and breathing flow rates significantly influence the aerosol TD pattern in the upper airway. The present study reports that airway tracheal wall is the new deposition hot spot for the CT-based geometry instead of bifurcating area for the idealized model, which might be helpful for zone-specific drug delivery to the respiratory airways.

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http://hdl.handle.net/10453/139461