Dietary Vitamin C Deficiency Is Associated with Health-Related Quality of Life and Cardiac Event-free Survival in Adults with Heart Failure

Wu, JR; Song, EK; Moser, DK; Lennie, TA

Dietary Vitamin C Deficiency Is Associated with Health-Related Quality of Life and Cardiac Event-free Survival in Adults with Heart Failure

Wu, JR Song, EK Moser, DK Lennie, TA

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Publication Type:: Journal Article
Citation:: Journal of Cardiovascular Nursing, 2019, 34 (1), pp. 29 - 35
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Wu, JR	en_US
dc.contributor.author	Song, EK	en_US
dc.contributor.author	Moser, DK	en_US
dc.contributor.author	Lennie, TA	en_US
dc.date.accessioned	2020-03-31T19:43:25Z
dc.date.available	2020-03-31T19:43:25Z
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Journal of Cardiovascular Nursing, 2019, 34 (1), pp. 29 - 35	en_US
dc.identifier.issn	0889-4655	en_US
dc.identifier.uri	http://hdl.handle.net/10453/139658
dc.description.abstract	© 2018 Lippincott Williams and Wilkins. All rights reserved. Background: Vitamin C deficiency is prevalent in adults with heart failure (HF). Little is known about the relationship of dietary Vitamin C deficiency with health outcomes in adults with HF. Objective: The study's aim was to determine the relationships of Vitamin C deficiency measured at baseline with health-related quality of life (HRQOL) and cardiac event-free survival in patients with HF measured 1 year later. Method: A total of 251 patients with HF completed a 4-day food diary. Dietary Vitamin C deficiency was defined as daily intake less than the estimated average requirement from the Institute of Medicine of 75 mg/d for men and 60 mg/d for women. Health-related quality of life was assessed using the Minnesota Living with Heart Failure Questionnaire at 12 months. Patients were followed for a median of 1 year to determine time to the first event of cardiac-related hospitalization or death. Data were analyzed by hierarchical linear and Cox proportional hazards regressions. Results: One hundred patients (40%) had Vitamin C deficiency. Dietary Vitamin C deficiency was associated with poorer HRQOL at 12 months (β = 0.16, P =.02) after controlling for demographic and clinical variables. During the follow-up period, 59 patients (24%) had cardiac events. In Cox regression, Vitamin C deficiency predicted shorter cardiac event-free survival after adjusting for the same covariates (hazards ratio, 1.95; 95% confidence interval, 1.08-3.51). Conclusion: Vitamin C deficiency was associated with poorer HRQOL and shorter cardiac event-free survival in patients with HF. The findings suggest that encouraging patients with HF to consume a diet rich in fruits/vegetables to prevent Vitamin C deficiency may lead to better health outcomes.	en_US
dc.relation.ispartof	Journal of Cardiovascular Nursing	en_US
dc.relation.isbasedon	10.1097/JCN.0000000000000521	en_US
dc.subject.classification	Nursing	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Ascorbic Acid Deficiency	en_US
dc.subject.mesh	Severity of Illness Index	en_US
dc.subject.mesh	Nutritional Status	en_US
dc.subject.mesh	Quality of Life	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Minnesota	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Heart Failure	en_US
dc.subject.mesh	Surveys and Questionnaires	en_US
dc.subject.mesh	Progression-Free Survival	en_US
dc.title	Dietary Vitamin C Deficiency Is Associated with Health-Related Quality of Life and Cardiac Event-free Survival in Adults with Heart Failure	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	34	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	1110 Nursing	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	34	en_US

Abstract:

© 2018 Lippincott Williams and Wilkins. All rights reserved. Background: Vitamin C deficiency is prevalent in adults with heart failure (HF). Little is known about the relationship of dietary Vitamin C deficiency with health outcomes in adults with HF. Objective: The study's aim was to determine the relationships of Vitamin C deficiency measured at baseline with health-related quality of life (HRQOL) and cardiac event-free survival in patients with HF measured 1 year later. Method: A total of 251 patients with HF completed a 4-day food diary. Dietary Vitamin C deficiency was defined as daily intake less than the estimated average requirement from the Institute of Medicine of 75 mg/d for men and 60 mg/d for women. Health-related quality of life was assessed using the Minnesota Living with Heart Failure Questionnaire at 12 months. Patients were followed for a median of 1 year to determine time to the first event of cardiac-related hospitalization or death. Data were analyzed by hierarchical linear and Cox proportional hazards regressions. Results: One hundred patients (40%) had Vitamin C deficiency. Dietary Vitamin C deficiency was associated with poorer HRQOL at 12 months (β = 0.16, P =.02) after controlling for demographic and clinical variables. During the follow-up period, 59 patients (24%) had cardiac events. In Cox regression, Vitamin C deficiency predicted shorter cardiac event-free survival after adjusting for the same covariates (hazards ratio, 1.95; 95% confidence interval, 1.08-3.51). Conclusion: Vitamin C deficiency was associated with poorer HRQOL and shorter cardiac event-free survival in patients with HF. The findings suggest that encouraging patients with HF to consume a diet rich in fruits/vegetables to prevent Vitamin C deficiency may lead to better health outcomes.

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http://hdl.handle.net/10453/139658