Protocol for the CHEST Australia trial: A phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer

Murray, SR; Murchie, P; Campbell, N; Walter, FM; Mazza, D; Habgood, E; Kutzer, Y; Martin, A; Goodall, S; Barnes, DJ; Emery, JD

Protocol for the CHEST Australia trial: A phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer

Murray, SR Murchie, P Campbell, N Walter, FM Mazza, D Habgood, E Kutzer, Y Martin, A Goodall, S

Barnes, DJ Emery, JD

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Publication Type:: Journal Article
Citation:: BMJ Open, 2015, 5 (5)
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Murray, SR	en_US
dc.contributor.author	Murchie, P	en_US
dc.contributor.author	Campbell, N	en_US
dc.contributor.author	Walter, FM	en_US
dc.contributor.author	Mazza, D	en_US
dc.contributor.author	Habgood, E	en_US
dc.contributor.author	Kutzer, Y	en_US
dc.contributor.author	Martin, A	en_US
dc.contributor.author	Goodall, S https://orcid.org/0000-0001-6611-6565	en_US
dc.contributor.author	Barnes, DJ	en_US
dc.contributor.author	Emery, JD	en_US
dc.date.accessioned	2020-03-31T21:57:35Z
dc.date.available	2020-03-31T21:57:35Z
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	BMJ Open, 2015, 5 (5)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/139669
dc.description.abstract	© 2015, BMJ Publishing Group. All rights reserved. Introduction: Lung cancer is the most common cancer worldwide, with 1.3 million new cases diagnosed every year. It has one of the lowest survival outcomes of any cancer because over two-thirds of patients are diagnosed when curative treatment is not possible. International research has focused on screening and community interventions to promote earlier presentation to a healthcare provider to improve early lung cancer detection. This paper describes the protocol for a phase II, multisite, randomised controlled trial, for patients at increased risk of lung cancer in the primary care setting, to facilitate early presentation with symptoms of lung cancer. Methods/analysis: The intervention is based on a previous Scottish CHEST Trial that comprised of a primary-care nurse consultation to discuss and implement a self-help manual, followed by selfmonitoring reminders to improve symptom appraisal and encourage help-seeking in patients at increased risk of lung cancer. We aim to recruit 550 patients from two Australian states: Western Australia and Victoria. Patients will be randomised to the Intervention (a health consultation involving a self-help manual, monthly prompts and spirometry) or Control (spirometry followed by usual care). Eligible participants are long-term smokers with at least 20 pack years, aged 55 and over, including ex-smokers if their cessation date was less than 15 years ago. The primary outcome is consultation rate for respiratory symptoms. Ethics and dissemination: Ethical approval has been obtained from The University of Western Australia's Human Research Ethics Committee (RA/4/1/6018) and The University of Melbourne Human Research Committee (1 441 433). A summary of the results will be disseminated to participants and we plan to publish the main trial outcomes in a single paper. Further publications are anticipated after further data analysis. Findings will be presented at national and international conferences from late 2016. Trial registration number: Australian New Zealand Clinical Trial Registry ACTRN 1261300039 3752.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/1064121
dc.relation.ispartof	BMJ Open	en_US
dc.relation.isbasedon	10.1136/bmjopen-2015-008046	en_US
dc.subject.mesh	Thorax	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Lung Neoplasms	en_US
dc.subject.mesh	Spirometry	en_US
dc.subject.mesh	Self Care	en_US
dc.subject.mesh	Smoking	en_US
dc.subject.mesh	Health Behavior	en_US
dc.subject.mesh	Research Design	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Nurses	en_US
dc.subject.mesh	Referral and Consultation	en_US
dc.subject.mesh	Primary Health Care	en_US
dc.subject.mesh	Patient Acceptance of Health Care	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Early Detection of Cancer	en_US
dc.subject.mesh	Diagnostic Self Evaluation	en_US
dc.title	Protocol for the CHEST Australia trial: A phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.for	111799 Public Health and Health Services not elsewhere classified	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1199 Other Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
utslib.copyright.status	open_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

© 2015, BMJ Publishing Group. All rights reserved. Introduction: Lung cancer is the most common cancer worldwide, with 1.3 million new cases diagnosed every year. It has one of the lowest survival outcomes of any cancer because over two-thirds of patients are diagnosed when curative treatment is not possible. International research has focused on screening and community interventions to promote earlier presentation to a healthcare provider to improve early lung cancer detection. This paper describes the protocol for a phase II, multisite, randomised controlled trial, for patients at increased risk of lung cancer in the primary care setting, to facilitate early presentation with symptoms of lung cancer. Methods/analysis: The intervention is based on a previous Scottish CHEST Trial that comprised of a primary-care nurse consultation to discuss and implement a self-help manual, followed by selfmonitoring reminders to improve symptom appraisal and encourage help-seeking in patients at increased risk of lung cancer. We aim to recruit 550 patients from two Australian states: Western Australia and Victoria. Patients will be randomised to the Intervention (a health consultation involving a self-help manual, monthly prompts and spirometry) or Control (spirometry followed by usual care). Eligible participants are long-term smokers with at least 20 pack years, aged 55 and over, including ex-smokers if their cessation date was less than 15 years ago. The primary outcome is consultation rate for respiratory symptoms. Ethics and dissemination: Ethical approval has been obtained from The University of Western Australia's Human Research Ethics Committee (RA/4/1/6018) and The University of Melbourne Human Research Committee (1 441 433). A summary of the results will be disseminated to participants and we plan to publish the main trial outcomes in a single paper. Further publications are anticipated after further data analysis. Findings will be presented at national and international conferences from late 2016. Trial registration number: Australian New Zealand Clinical Trial Registry ACTRN 1261300039 3752.

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http://hdl.handle.net/10453/139669