Prevalence of vascular complications and factors predictive of their development in young adults with type 1 diabetes: Systematic literature review

James, S; Gallagher, R; Dunbabin, J; Perry, L

Prevalence of vascular complications and factors predictive of their development in young adults with type 1 diabetes: Systematic literature review

James, S

Gallagher, R

Dunbabin, J Perry, L

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Publication Type:: Journal Article
Citation:: BMC Research Notes, 2014, 7 (1)
Issue Date:: 2014-09-02

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Field	Value	Language
dc.contributor.author	James, S https://orcid.org/0000-0002-3928-9206	en_US
dc.contributor.author	Gallagher, R https://orcid.org/0000-0001-5588-9351	en_US
dc.contributor.author	Dunbabin, J	en_US
dc.contributor.author	Perry, L https://orcid.org/0000-0002-8507-1283	en_US
dc.date.accessioned	2020-04-08T07:19:14Z
dc.date.available	2014-08-04	en_US
dc.date.available	2020-04-08T07:19:14Z
dc.date.issued	2014-09-02	en_US
dc.identifier.citation	BMC Research Notes, 2014, 7 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/139903
dc.description.abstract	Background: Vascular complications curtail life expectancy and quality of life in type 1 diabetes and development at younger ages is particularly detrimental. To date no review has summarised the prevalence or factors predicting their development in young adults.Methods. A quantitative epidemiological systematic review was conducted to identify the prevalence and predictive factors for development of retinopathy, nephropathy and hypertension in young adults (sample age mean [plus 1SD] 18-30 years) with type 1 diabetes, using processes adapted from established review methods set out by the Centre for Reviews and Dissemination. MEDLINE (Ovid), Scopus (Elsevier), CINAHL, Science Direct (Elsevier), Google Scholar and Cochrane databases were searched to identify relevant articles published between 1993 and June 2014. From this eleven papers were retrieved, appraised and results summarised by three reviewers using established methods.Results: Some form of retinopathy occurred in up to almost half of participants; more severe forms affected up to one in ten. One in six was reported with microalbuminuria; one in 14 had macroalbuminuria. Hypertension occurred in almost one in two participants. Applying out-dated high thresholds this decreased to approximately one in ten participants. Glycaemic control was a consistent predictor of vascular disease in this age group.Conclusion: Prevalence rates of retinopathy, nephropathy and hypertension in young adults with type 1 diabetes emphasise the importance of regular complication screening for early detection and treatment. The predictive effect of glycaemic control reinforces its importance for prevention of vascular complications. © 2014 James et al.; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	BMC Research Notes	en_US
dc.relation.isbasedon	10.1186/1756-0500-7-593	en_US
dc.subject.classification	Bioinformatics	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Diabetic Angiopathies	en_US
dc.subject.mesh	Diabetes Mellitus, Type 1	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Prevalence of vascular complications and factors predictive of their development in young adults with type 1 diabetes: Systematic literature review	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	7	en_US
utslib.for	1110 Nursing	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1199 Other Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

Background: Vascular complications curtail life expectancy and quality of life in type 1 diabetes and development at younger ages is particularly detrimental. To date no review has summarised the prevalence or factors predicting their development in young adults.Methods. A quantitative epidemiological systematic review was conducted to identify the prevalence and predictive factors for development of retinopathy, nephropathy and hypertension in young adults (sample age mean [plus 1SD] 18-30 years) with type 1 diabetes, using processes adapted from established review methods set out by the Centre for Reviews and Dissemination. MEDLINE (Ovid), Scopus (Elsevier), CINAHL, Science Direct (Elsevier), Google Scholar and Cochrane databases were searched to identify relevant articles published between 1993 and June 2014. From this eleven papers were retrieved, appraised and results summarised by three reviewers using established methods.Results: Some form of retinopathy occurred in up to almost half of participants; more severe forms affected up to one in ten. One in six was reported with microalbuminuria; one in 14 had macroalbuminuria. Hypertension occurred in almost one in two participants. Applying out-dated high thresholds this decreased to approximately one in ten participants. Glycaemic control was a consistent predictor of vascular disease in this age group.Conclusion: Prevalence rates of retinopathy, nephropathy and hypertension in young adults with type 1 diabetes emphasise the importance of regular complication screening for early detection and treatment. The predictive effect of glycaemic control reinforces its importance for prevention of vascular complications. © 2014 James et al.; licensee BioMed Central Ltd.

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http://hdl.handle.net/10453/139903