Heart Transplantation With Donation After Circulatory Death.

Niederberger, P; Farine, E; Raillard, M; Dornbierer, M; Freed, DH; Large, SR; Chew, HC; MacDonald, PS; Messer, SJ; White, CW; Carrel, TP; Tevaearai Stahel, HT; Longnus, SL

Heart Transplantation With Donation After Circulatory Death.

Niederberger, P Farine, E Raillard, M Dornbierer, M Freed, DH Large, SR Chew, HC MacDonald, PS

Messer, SJ White, CW Carrel, TP Tevaearai Stahel, HT Longnus, SL

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Publication Type:: Journal Article
Citation:: Circ Heart Fail, 2019, 12 (4), pp. e005517 - ?
Issue Date:: 2019-04

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Field	Value	Language
dc.contributor.author	Niederberger, P	en_US
dc.contributor.author	Farine, E	en_US
dc.contributor.author	Raillard, M	en_US
dc.contributor.author	Dornbierer, M	en_US
dc.contributor.author	Freed, DH	en_US
dc.contributor.author	Large, SR	en_US
dc.contributor.author	Chew, HC	en_US
dc.contributor.author	MacDonald, PS https://orcid.org/0000-0001-5378-2825	en_US
dc.contributor.author	Messer, SJ	en_US
dc.contributor.author	White, CW	en_US
dc.contributor.author	Carrel, TP	en_US
dc.contributor.author	Tevaearai Stahel, HT	en_US
dc.contributor.author	Longnus, SL	en_US
dc.date.accessioned	2020-04-16T06:27:08Z
dc.date.available	2020-04-16T06:27:08Z
dc.date.issued	2019-04	en_US
dc.identifier.citation	Circ Heart Fail, 2019, 12 (4), pp. e005517 - ?	en_US
dc.identifier.uri	http://hdl.handle.net/10453/140031
dc.description.abstract	Heart transplantation remains the preferred option for improving quality of life and survival for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of cardiac grafts has become an obstacle. Increasing organ availability with donation after circulatory death (DCD) may be a promising option to overcome the organ shortage. Unlike conventional donation after brain death, DCD organs undergo a period of warm, global ischemia between circulatory arrest and graft procurement, which raises concerns for graft quality. Nonetheless, the potential of DCD heart transplantation is being reconsidered, after reports of more than 70 cases in Australia and the United Kingdom over the past 3 years. Ensuring optimal patient outcomes and generalized adoption of DCD in heart transplantation, however, requires further development of clinical protocols, which in turn require a better understanding of cardiac ischemia-reperfusion injury and the various possibilities to limit its adverse effects. Thus, we aim to provide an overview of the knowledge obtained with preclinical studies in animal models of DCD heart transplantation, to facilitate and promote the most effective and efficient advancement in preclinical research. A literature search of the PubMed database was performed to identify all relevant preclinical studies in DCD heart transplantation. Specific aspects relevant for DCD heart transplantation were analyzed, including animal models, graft procurement and storage conditions, cardioprotective approaches, and graft evaluation strategies. Several potential therapeutic strategies for optimizing graft quality are identified, and recommendations for further preclinical research are provided.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Circ Heart Fail	en_US
dc.relation.isbasedon	10.1161/CIRCHEARTFAILURE.118.005517	en_US
dc.subject.classification	Cardiovascular System & Hematology	en_US
dc.subject.mesh	Cardiovascular System	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Brain Death	en_US
dc.subject.mesh	Death	en_US
dc.subject.mesh	Heart Transplantation	en_US
dc.subject.mesh	Graft Rejection	en_US
dc.subject.mesh	Graft Survival	en_US
dc.subject.mesh	Tissue Donors	en_US
dc.subject.mesh	Tissue and Organ Procurement	en_US
dc.subject.mesh	Warm Ischemia	en_US
dc.subject.mesh	Heart Failure	en_US
dc.title	Heart Transplantation With Donation After Circulatory Death.	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	12	en_US
utslib.location.activity	United States	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	1116 Medical Physiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

Heart transplantation remains the preferred option for improving quality of life and survival for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of cardiac grafts has become an obstacle. Increasing organ availability with donation after circulatory death (DCD) may be a promising option to overcome the organ shortage. Unlike conventional donation after brain death, DCD organs undergo a period of warm, global ischemia between circulatory arrest and graft procurement, which raises concerns for graft quality. Nonetheless, the potential of DCD heart transplantation is being reconsidered, after reports of more than 70 cases in Australia and the United Kingdom over the past 3 years. Ensuring optimal patient outcomes and generalized adoption of DCD in heart transplantation, however, requires further development of clinical protocols, which in turn require a better understanding of cardiac ischemia-reperfusion injury and the various possibilities to limit its adverse effects. Thus, we aim to provide an overview of the knowledge obtained with preclinical studies in animal models of DCD heart transplantation, to facilitate and promote the most effective and efficient advancement in preclinical research. A literature search of the PubMed database was performed to identify all relevant preclinical studies in DCD heart transplantation. Specific aspects relevant for DCD heart transplantation were analyzed, including animal models, graft procurement and storage conditions, cardioprotective approaches, and graft evaluation strategies. Several potential therapeutic strategies for optimizing graft quality are identified, and recommendations for further preclinical research are provided.

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http://hdl.handle.net/10453/140031