Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?

Kummrow, M; Hiho, S; Hudson, F; Cantwell, L; Mulley, WR; D'Orsogna, L; Testro, A; Pavlovic, J; MacDonald, P; Sullivan, LC; Snell, GI; Westall, GP

Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?

Kummrow, M Hiho, S Hudson, F Cantwell, L Mulley, WR D'Orsogna, L

Testro, A Pavlovic, J MacDonald, P

Sullivan, LC Snell, GI Westall, GP

Permalink

Publication Type:: Journal Article
Citation:: Am J Transplant, 2019, 19 (5), pp. 1577 - 1581
Issue Date:: 2019-05

Closed Access

	Filename	Description	Size
	ajt.15262.pdf	Published Version	316.5 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Kummrow, M	en_US
dc.contributor.author	Hiho, S	en_US
dc.contributor.author	Hudson, F	en_US
dc.contributor.author	Cantwell, L	en_US
dc.contributor.author	Mulley, WR	en_US
dc.contributor.author	D'Orsogna, L https://orcid.org/0000-0002-6824-4189	en_US
dc.contributor.author	Testro, A	en_US
dc.contributor.author	Pavlovic, J	en_US
dc.contributor.author	MacDonald, P https://orcid.org/0000-0001-5378-2825	en_US
dc.contributor.author	Sullivan, LC	en_US
dc.contributor.author	Snell, GI	en_US
dc.contributor.author	Westall, GP	en_US
dc.date.accessioned	2020-04-16T07:28:48Z
dc.date.available	2019-01-06	en_US
dc.date.available	2020-04-16T07:28:48Z
dc.date.issued	2019-05	en_US
dc.identifier.citation	Am J Transplant, 2019, 19 (5), pp. 1577 - 1581	en_US
dc.identifier.uri	http://hdl.handle.net/10453/140046
dc.description.abstract	Antibody-mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti-HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Am J Transplant	en_US
dc.relation.isbasedon	10.1111/ajt.15262	en_US
dc.subject.classification	Surgery	en_US
dc.title	Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	19	en_US
utslib.location.activity	United States	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

Antibody-mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti-HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/140046