Promoted chondrogenesis of hMCSs with controlled release of TGF-β3 via microfluidics synthesized alginate nanogels

Mahmoudi, Z; Mohammadnejad, J; Razavi Bazaz, S; Abouei Mehrizi, A; Saidijam, M; Dinarvand, R; Ebrahimi Warkiani, M; Soleimani, M

Promoted chondrogenesis of hMCSs with controlled release of TGF-β3 via microfluidics synthesized alginate nanogels

Mahmoudi, Z Mohammadnejad, J Razavi Bazaz, S

Abouei Mehrizi, A Saidijam, M Dinarvand, R Ebrahimi Warkiani, M

Soleimani, M

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Carbohydrate Polymers, 2020, 229, pp. 115551-115551
Issue Date:: 2020

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Field	Value	Language
dc.contributor.author	Mahmoudi, Z
dc.contributor.author	Mohammadnejad, J
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361
dc.contributor.author	Abouei Mehrizi, A
dc.contributor.author	Saidijam, M
dc.contributor.author	Dinarvand, R
dc.contributor.author	Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944
dc.contributor.author	Soleimani, M
dc.date.accessioned	2020-05-11T05:16:53Z
dc.date.available	2019-10-28
dc.date.available	2020-05-11T05:16:53Z
dc.date.issued	2020
dc.identifier.citation	Carbohydrate Polymers, 2020, 229, pp. 115551-115551
dc.identifier.issn	0144-8617
dc.identifier.issn	1879-1344
dc.identifier.uri	http://hdl.handle.net/10453/140626
dc.description.abstract	The field of cartilage tissue engineering has been evolved in the last decade and a myriad of scaffolding biomaterials and bioactive agents have been proposed. Controlled release of growth factors encapsulated in the polymeric nanomaterials has been of interest notably for the repair of damaged articular cartilage. Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-β3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs). Alginate nanogels with adjustable sizes were synthesized by fine-tuning the flow rate ratio (FRR) in the microfluidic device consisting of cross-junction microchannels. The result of present study showed that the proposed approach can be a promising tool to synthesize bioactive -loaded polymeric nanogels for applications in drug delivery and tissue engineering.
dc.format	Print-Electronic
dc.language	en
dc.publisher	Elsevier BV
dc.relation.ispartof	Carbohydrate Polymers
dc.relation.isbasedon	10.1016/j.carbpol.2019.115551
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0305 Organic Chemistry, 0908 Food Sciences
dc.subject.classification	Polymers
dc.title	Promoted chondrogenesis of hMCSs with controlled release of TGF-β3 via microfluidics synthesized alginate nanogels
dc.type	Journal Article
utslib.citation.volume	229
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0305 Organic Chemistry
utslib.for	0908 Food Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2020-05-11T05:16:52Z
pubs.publication-status	Published
pubs.volume	229
utslib.start-page	115551

Abstract:

The field of cartilage tissue engineering has been evolved in the last decade and a myriad of scaffolding biomaterials and bioactive agents have been proposed. Controlled release of growth factors encapsulated in the polymeric nanomaterials has been of interest notably for the repair of damaged articular cartilage. Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-β3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs). Alginate nanogels with adjustable sizes were synthesized by fine-tuning the flow rate ratio (FRR) in the microfluidic device consisting of cross-junction microchannels. The result of present study showed that the proposed approach can be a promising tool to synthesize bioactive -loaded polymeric nanogels for applications in drug delivery and tissue engineering.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/140626