Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

Bakshi, HA; Zoubi, MSA; Faruck, HL; Aljabali, AAA; Rabi, FA; Hafiz, AA; Al-Batanyeh, KM; Al-Trad, B; Ansari, P; Nasef, MM; Charbe, NB; Satija, S; Mehta, M; Mishra, V; Gupta, G; Abobaker, S; Negi, P; Azzouz, IM; Dardouri, AAK; Dureja, H; Prasher, P; Chellappan, DK; Dua, K; Silva, MWD; Tanani, ME; McCarron, PA; M Tambuwala, M

Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

Bakshi, HA Zoubi, MSA Faruck, HL Aljabali, AAA Rabi, FA Hafiz, AA Al-Batanyeh, KM Al-Trad, B Ansari, P Nasef, MM Charbe, NB Satija, S Mehta, M Mishra, V Gupta, G Abobaker, S Negi, P Azzouz, IM Dardouri, AAK Dureja, H Prasher, P Chellappan, DK Dua, K

Silva, MWD Tanani, ME McCarron, PA M Tambuwala, M

Permalink

Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Nutrients, 2020, 12, (6), pp. 1901-1901
Issue Date:: 2020-06-26

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Accepted versionAdobe PDF (1.72 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Bakshi, HA
dc.contributor.author	Zoubi, MSA
dc.contributor.author	Faruck, HL
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Rabi, FA
dc.contributor.author	Hafiz, AA
dc.contributor.author	Al-Batanyeh, KM
dc.contributor.author	Al-Trad, B
dc.contributor.author	Ansari, P
dc.contributor.author	Nasef, MM
dc.contributor.author	Charbe, NB
dc.contributor.author	Satija, S
dc.contributor.author	Mehta, M
dc.contributor.author	Mishra, V
dc.contributor.author	Gupta, G
dc.contributor.author	Abobaker, S
dc.contributor.author	Negi, P
dc.contributor.author	Azzouz, IM
dc.contributor.author	Dardouri, AAK
dc.contributor.author	Dureja, H
dc.contributor.author	Prasher, P
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Silva, MWD
dc.contributor.author	Tanani, ME
dc.contributor.author	McCarron, PA
dc.contributor.author	M Tambuwala, M
dc.date.accessioned	2020-07-03T02:56:57Z
dc.date.available	2020-06-15
dc.date.available	2020-07-03T02:56:57Z
dc.date.issued	2020-06-26
dc.identifier.citation	Nutrients, 2020, 12, (6), pp. 1901-1901
dc.identifier.issn	2072-6643
dc.identifier.issn	2072-6643
dc.identifier.uri	http://hdl.handle.net/10453/141718
dc.description.abstract	Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	Nutrients
dc.relation.isbasedon	10.3390/nu12061901
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0908 Food Sciences, 1111 Nutrition and Dietetics
dc.title	Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	Switzerland
utslib.for	0908 Food Sciences
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2020-07-03T02:56:51Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	6

Abstract:

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/141718