Fatherhood Following Treatment for Testicular Cancer: A Systematic Review and Meta-Analyses.

Gerstl, B; Bertoldo, MJ; Sullivan, E; Volckmar, X; Kerr, A; Wand, H; Ives, A; Albalawi, O; Anazodo, A

Fatherhood Following Treatment for Testicular Cancer: A Systematic Review and Meta-Analyses.

Gerstl, B Bertoldo, MJ Sullivan, E

Volckmar, X Kerr, A Wand, H Ives, A Albalawi, O Anazodo, A

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Publisher:: Mary Ann Liebert Inc
Publication Type:: Journal Article
Citation:: Journal of adolescent and young adult oncology, 2020, 9, (3), pp. 341-353
Issue Date:: 2020-06

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Field	Value	Language
dc.contributor.author	Gerstl, B
dc.contributor.author	Bertoldo, MJ
dc.contributor.author	Sullivan, E https://orcid.org/0000-0002-8718-2753
dc.contributor.author	Volckmar, X
dc.contributor.author	Kerr, A
dc.contributor.author	Wand, H
dc.contributor.author	Ives, A
dc.contributor.author	Albalawi, O
dc.contributor.author	Anazodo, A
dc.date.accessioned	2020-08-31T04:45:56Z
dc.date.available	2020-08-31T04:45:56Z
dc.date.issued	2020-06
dc.identifier.citation	Journal of adolescent and young adult oncology, 2020, 9, (3), pp. 341-353
dc.identifier.issn	2156-5333
dc.identifier.issn	2156-535X
dc.identifier.uri	http://hdl.handle.net/10453/142436
dc.description.abstract	Purpose: Testicular cancer (TC) is considered the most commonly diagnosed malignancy in males between 15 and 34 years of age. The objective of this study is to systematically review and meta-analyze studies on fatherhood following treatment for TC. Methods: We reviewed studies reporting on fatherhood following TC from Medline and Embase search engines by developing search strategies. Only studies including patients with TC and at least one reproductive variable were considered as part of the analysis. Estimate of heterogeneity was calculated using the I2 statistic. Meta-analyses employing a fixed effects model were also applied as an additional measure of sensitivity. Results: A total of 27 studies were included which reported on fatherhood after treatment for TC. A meta-analysis of included studies with subgroup analysis was conducted. Subgroup analysis, for the combined studies, indicated an overall pooled pregnancy rate of 22% (95% confidence intervals [CI]: 0.21-0.23; I2 = 98.1%) for couples who conceived after TC. Of those couples that became pregnant, 11% (95% CI: 0.07-0.16; I2 = 8.5%) experienced a miscarriage. Fatherhood was experienced by 37% (95% CI: 0.35-0.39; I2 = 98.1%) of males following treatment for TC. Conclusions: Male cancer patients should be offered discussions, information, and counseling regarding the impact that TC treatment can have on fertility. Furthermore, sperm banking must be recommended to all patients before starting treatment.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Mary Ann Liebert Inc
dc.relation.ispartof	Journal of adolescent and young adult oncology
dc.relation.isbasedon	10.1089/jayao.2019.0164
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1110 Nursing, 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services
dc.title	Fatherhood Following Treatment for Testicular Cancer: A Systematic Review and Meta-Analyses.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	United States
utslib.for	1110 Nursing
utslib.for	1112 Oncology and Carcinogenesis
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-08-31T04:45:52Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	3

Abstract:

Purpose: Testicular cancer (TC) is considered the most commonly diagnosed malignancy in males between 15 and 34 years of age. The objective of this study is to systematically review and meta-analyze studies on fatherhood following treatment for TC. Methods: We reviewed studies reporting on fatherhood following TC from Medline and Embase search engines by developing search strategies. Only studies including patients with TC and at least one reproductive variable were considered as part of the analysis. Estimate of heterogeneity was calculated using the I2 statistic. Meta-analyses employing a fixed effects model were also applied as an additional measure of sensitivity. Results: A total of 27 studies were included which reported on fatherhood after treatment for TC. A meta-analysis of included studies with subgroup analysis was conducted. Subgroup analysis, for the combined studies, indicated an overall pooled pregnancy rate of 22% (95% confidence intervals [CI]: 0.21-0.23; I2 = 98.1%) for couples who conceived after TC. Of those couples that became pregnant, 11% (95% CI: 0.07-0.16; I2 = 8.5%) experienced a miscarriage. Fatherhood was experienced by 37% (95% CI: 0.35-0.39; I2 = 98.1%) of males following treatment for TC. Conclusions: Male cancer patients should be offered discussions, information, and counseling regarding the impact that TC treatment can have on fertility. Furthermore, sperm banking must be recommended to all patients before starting treatment.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/142436