Application of salivary noncoding microRNAs for the diagnosis of oral cancers.

Deutsch, FT; Khoury, SJ; Sunwoo, JB; Elliott, MS; Tran, NT

Application of salivary noncoding microRNAs for the diagnosis of oral cancers.

Deutsch, FT Khoury, SJ Sunwoo, JB Elliott, MS Tran, NT

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Head and Neck: journal for the sciences and specialities of the head and neck, 2020, 42, (10), pp. 3072-3083
Issue Date:: 2020-07-20

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Field	Value	Language
dc.contributor.author	Deutsch, FT
dc.contributor.author	Khoury, SJ
dc.contributor.author	Sunwoo, JB
dc.contributor.author	Elliott, MS
dc.contributor.author	Tran, NT
dc.date.accessioned	2020-10-01T01:43:31Z
dc.date.available	2020-06-09
dc.date.available	2020-10-01T01:43:31Z
dc.date.issued	2020-07-20
dc.identifier.citation	Head and Neck: journal for the sciences and specialities of the head and neck, 2020, 42, (10), pp. 3072-3083
dc.identifier.issn	1043-3074
dc.identifier.issn	1097-0347
dc.identifier.uri	http://hdl.handle.net/10453/142954
dc.description.abstract	Oral cancer is on the rise globally and survival rates, despite improvements in clinical care, have not significantly improved. Early detection followed by immediate intervention is key to improving patient outcomes. The use of biomarkers has changed the diagnostic landscape for many cancers. For oral cancers, visual inspection followed by a tissue biopsy is standard practice. The discovery of microRNAs as potential biomarkers has attracted clinical interest but several challenges remain. These microRNAs can be found in bodily fluids such as blood and saliva which have been investigated as potential sources of biomarker discovery. As oral cancer is localized within the oral cavity, saliva may contain clinically relevant molecular markers for disease detection. Our review provides an outline of the current advances for the application of salivary microRNAs in oral cancer. We also provide a technical guide for the processing of salivary RNAs to ensure accurate clinical measurement and validation.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Head and Neck: journal for the sciences and specialities of the head and neck
dc.relation.isbasedon	10.1002/hed.26348
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1105 Dentistry
dc.subject.classification	Otorhinolaryngology
dc.title	Application of salivary noncoding microRNAs for the diagnosis of oral cancers.
dc.type	Journal Article
utslib.citation.volume	42
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1105 Dentistry
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-01T01:43:19Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	42
utslib.citation.issue	10

Abstract:

Oral cancer is on the rise globally and survival rates, despite improvements in clinical care, have not significantly improved. Early detection followed by immediate intervention is key to improving patient outcomes. The use of biomarkers has changed the diagnostic landscape for many cancers. For oral cancers, visual inspection followed by a tissue biopsy is standard practice. The discovery of microRNAs as potential biomarkers has attracted clinical interest but several challenges remain. These microRNAs can be found in bodily fluids such as blood and saliva which have been investigated as potential sources of biomarker discovery. As oral cancer is localized within the oral cavity, saliva may contain clinically relevant molecular markers for disease detection. Our review provides an outline of the current advances for the application of salivary microRNAs in oral cancer. We also provide a technical guide for the processing of salivary RNAs to ensure accurate clinical measurement and validation.

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http://hdl.handle.net/10453/142954