SF-6D health state utilities for lifestyle, socio-demographic and clinical characteristics of a large international cohort of people with multiple sclerosis

Campbell, JA; Jelinek, GA; Weiland, TJ; Nag, N; Neate, SL; Palmer, AJ; Mulhern, B; De Livera, A; Simpson, S

SF-6D health state utilities for lifestyle, socio-demographic and clinical characteristics of a large international cohort of people with multiple sclerosis

Campbell, JA Jelinek, GA Weiland, TJ Nag, N Neate, SL Palmer, AJ Mulhern, B

De Livera, A Simpson, S

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Publisher:: Springer Verlag
Publication Type:: Journal Article
Citation:: Quality of Life Research, 2020, 29, (9), pp. 2509-2527
Issue Date:: 2020

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Field	Value	Language
dc.contributor.author	Campbell, JA
dc.contributor.author	Jelinek, GA
dc.contributor.author	Weiland, TJ
dc.contributor.author	Nag, N
dc.contributor.author	Neate, SL
dc.contributor.author	Palmer, AJ
dc.contributor.author	Mulhern, B https://orcid.org/0000-0003-3656-8063
dc.contributor.author	De Livera, A
dc.contributor.author	Simpson, S
dc.date.accessioned	2020-10-05T01:09:29Z
dc.date.available	2020-04-10
dc.date.available	2020-10-05T01:09:29Z
dc.date.issued	2020
dc.identifier.citation	Quality of Life Research, 2020, 29, (9), pp. 2509-2527
dc.identifier.issn	0962-9343
dc.identifier.issn	1573-2649
dc.identifier.uri	http://hdl.handle.net/10453/143079
dc.description.abstract	Background While many studies have examined the impacts of multiple sclerosis (MS) on health-related quality of life (HRQoL), none have used the SF-6D multi-attribute utility instrument in a large international cohort (> 2000 subjects) of people with MS. Objectives To derive SF-6D health state utilities (HSUs) for participants of the HOLISM (Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis) international cohort and to describe the distribution and determinants thereof. Methods HSUs were generated using the SF-6D for participants with sufficient SF-36 data [n = 2185/2466 (88.6%)]. Mean HSUs for sociodemographic, clinical and modifiable lifestyle factors (including diet, physical activity, supplement use) were evaluated. Determinants of HSU were then evaluated by linear regression, adjusted for age, sex, MS type, disability, fatigue, and prescription antidepressant use. Results Mean HSU for the sample was 0.67 (SD = 0.13) and diminished with increasing MS-related disability, robust to adjustment, supporting the SF-6D’s discriminatory power in people with MS. Severe disability and clinically significant fatigue were each associated with 11% lower HSU (95% CI = − 0.13, − 0.10 and − 0.12, − 0.10), and depression risk with 10%-lower HSU (95% CI = − 0.11, − 0.08). Employment, higher socioeconomic and married/partnered statuses, larger social-network size, greater physical activity, and vitamin D and omega-3 supplement use were associated with significantly higher HSU, and overweight/obese BMI and tobacco smoking with lower HSU. Age, sex, and education were not associated. Conclusion Modifiable lifestyle factors including healthy diet, increased physical activity and supplement use were associated with higher HRQOL among people with MS. The SF-6D instrument revealed significant discriminatory power in this international cohort of people with MS.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Verlag
dc.relation.ispartof	Quality of Life Research
dc.relation.isbasedon	10.1007/s11136-020-02505-6
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1117 Public Health and Health Services, 1701 Psychology
dc.subject.classification	Health Policy & Services
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Life Style
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Multiple Sclerosis
dc.subject.mesh	Quality of Life
dc.subject.mesh	Socioeconomic Factors
dc.subject.mesh	Young Adult
dc.title	SF-6D health state utilities for lifestyle, socio-demographic and clinical characteristics of a large international cohort of people with multiple sclerosis
dc.type	Journal Article
utslib.citation.volume	29
utslib.location.activity	Netherlands
utslib.for	1117 Public Health and Health Services
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-05T01:09:26Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	29
utslib.citation.issue	9

Abstract:

Background While many studies have examined the impacts of multiple sclerosis (MS) on health-related quality of life (HRQoL), none have used the SF-6D multi-attribute utility instrument in a large international cohort (> 2000 subjects) of people with MS. Objectives To derive SF-6D health state utilities (HSUs) for participants of the HOLISM (Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis) international cohort and to describe the distribution and determinants thereof. Methods HSUs were generated using the SF-6D for participants with sufficient SF-36 data [n = 2185/2466 (88.6%)]. Mean HSUs for sociodemographic, clinical and modifiable lifestyle factors (including diet, physical activity, supplement use) were evaluated. Determinants of HSU were then evaluated by linear regression, adjusted for age, sex, MS type, disability, fatigue, and prescription antidepressant use. Results Mean HSU for the sample was 0.67 (SD = 0.13) and diminished with increasing MS-related disability, robust to adjustment, supporting the SF-6D’s discriminatory power in people with MS. Severe disability and clinically significant fatigue were each associated with 11% lower HSU (95% CI = − 0.13, − 0.10 and − 0.12, − 0.10), and depression risk with 10%-lower HSU (95% CI = − 0.11, − 0.08). Employment, higher socioeconomic and married/partnered statuses, larger social-network size, greater physical activity, and vitamin D and omega-3 supplement use were associated with significantly higher HSU, and overweight/obese BMI and tobacco smoking with lower HSU. Age, sex, and education were not associated. Conclusion Modifiable lifestyle factors including healthy diet, increased physical activity and supplement use were associated with higher HRQOL among people with MS. The SF-6D instrument revealed significant discriminatory power in this international cohort of people with MS.

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http://hdl.handle.net/10453/143079