A miniaturized piezoresistive flow sensor for real-time monitoring of intravenous infusion.

Hagihghi, R; Razmjou, A; Orooji, Y; Warkiani, ME; Asadnia, M

A miniaturized piezoresistive flow sensor for real-time monitoring of intravenous infusion.

Hagihghi, R Razmjou, A Orooji, Y Warkiani, ME Asadnia, M

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2020, 108, (2), pp. 568-576
Issue Date:: 2020-02

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Field	Value	Language
dc.contributor.author	Hagihghi, R
dc.contributor.author	Razmjou, A
dc.contributor.author	Orooji, Y
dc.contributor.author	Warkiani, ME
dc.contributor.author	Asadnia, M
dc.date.accessioned	2020-10-17T07:05:14Z
dc.date.available	2019-04-26
dc.date.available	2020-10-17T07:05:14Z
dc.date.issued	2020-02
dc.identifier.citation	Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2020, 108, (2), pp. 568-576
dc.identifier.issn	1552-4973
dc.identifier.issn	1552-4981
dc.identifier.uri	http://hdl.handle.net/10453/143332
dc.description.abstract	Drug overdose (DO) is considered one of the current issues of intravenous (IV) infusion particularly resulting in serious injuries and deaths. Malfunction of infusion pumps is reported as the main cause of the drug overdose. Live monitoring and flow rate calculation by health professionals have been practicing to avoid DO. However, human errors and miscalculations are inevitable. A secondary measurement tool is required to avoid the risk of OD when infusion pump malfunctions cannot be detected immediately. Here, inspired by nature, we developed a real-time monitoring device through which an administrator can review, evaluate, and modify the IV infusion process. Our flow sensor possesses an erected polymer hair cell on a multi-layered silicon base forming from a patterned gold strained gauge layer on a piezoresistive liquid crystal polymer (LCP) membrane. Gold strain gauges on an LCP membrane have been used instead of a piezoresistive silicon membrane as the sensing element. The combination of gold strain gauges and LCP membrane provides better sensitivity than a piezoresistive silicon membrane of the same dimensions and thickness. We also miniaturized our biocompatible sensor such that it can be possible to install it inside the IV tube in contact with the liquid providing an in-suite online flow monitoring. The proposed LCP membrane sensor is compared with two commercially available IV sensors to validate its flow sensing ability. The experimental results demonstrate that the proposed sensor provides a low threshold detection limit of 5 mL/hr, which betters the performance of other commercial sensors at low flow rates.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Journal of Biomedical Materials Research Part B: Applied Biomaterials
dc.relation.isbasedon	10.1002/jbm.b.34412
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0903 Biomedical Engineering, 0912 Materials Engineering
dc.subject.classification	Biomedical Engineering
dc.title	A miniaturized piezoresistive flow sensor for real-time monitoring of intravenous infusion.
dc.type	Journal Article
utslib.citation.volume	108
utslib.location.activity	United States
utslib.for	0903 Biomedical Engineering
utslib.for	0912 Materials Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2020-10-17T07:05:05Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	108
utslib.citation.issue	2

Abstract:

Drug overdose (DO) is considered one of the current issues of intravenous (IV) infusion particularly resulting in serious injuries and deaths. Malfunction of infusion pumps is reported as the main cause of the drug overdose. Live monitoring and flow rate calculation by health professionals have been practicing to avoid DO. However, human errors and miscalculations are inevitable. A secondary measurement tool is required to avoid the risk of OD when infusion pump malfunctions cannot be detected immediately. Here, inspired by nature, we developed a real-time monitoring device through which an administrator can review, evaluate, and modify the IV infusion process. Our flow sensor possesses an erected polymer hair cell on a multi-layered silicon base forming from a patterned gold strained gauge layer on a piezoresistive liquid crystal polymer (LCP) membrane. Gold strain gauges on an LCP membrane have been used instead of a piezoresistive silicon membrane as the sensing element. The combination of gold strain gauges and LCP membrane provides better sensitivity than a piezoresistive silicon membrane of the same dimensions and thickness. We also miniaturized our biocompatible sensor such that it can be possible to install it inside the IV tube in contact with the liquid providing an in-suite online flow monitoring. The proposed LCP membrane sensor is compared with two commercially available IV sensors to validate its flow sensing ability. The experimental results demonstrate that the proposed sensor provides a low threshold detection limit of 5 mL/hr, which betters the performance of other commercial sensors at low flow rates.

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http://hdl.handle.net/10453/143332