Physico-mechanical, morphological and biomedical properties of a novel natural wound dressing material.

Tavakoli, J

Physico-mechanical, morphological and biomedical properties of a novel natural wound dressing material.

Tavakoli, J

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Publisher:: ELSEVIER SCIENCE BV
Publication Type:: Journal Article
Citation:: Journal of the mechanical behavior of biomedical materials, 2017, 65, pp. 373-382
Issue Date:: 2017-01

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Field	Value	Language
dc.contributor.author	Tavakoli, J https://orcid.org/0000-0002-0696-6530
dc.date.accessioned	2020-11-12T03:16:57Z
dc.date.available	2016-09-04
dc.date.available	2020-11-12T03:16:57Z
dc.date.issued	2017-01
dc.identifier.citation	Journal of the mechanical behavior of biomedical materials, 2017, 65, pp. 373-382
dc.identifier.issn	1751-6161
dc.identifier.issn	1878-0180
dc.identifier.uri	http://hdl.handle.net/10453/143940
dc.description.abstract	Wound healing as a complex biological process greatly affects the quality of patients׳ lives. The high initial cost of wound treatment using advanced wound dressing is a major concern that warrants more attention. Because of the similarities between body macromolecules and polysaccharides and proteoglycans, gelatin and starch were used extensively as wound dressings; however their solubility in aqueous environment is known as a major drawback. Crosslinking, as a common method for enhancing mechanical properties, has its own limitation as some chemical cross-likers reduce biocompatibility. In this research, a simple and economical method for the fabrication of a novel wound dressing foam based on natural polymers of starch and gelatin with borax as the crosslinking agent is introduced. To evaluate the utility of the foams for wound dressing application, morphology, swelling behaviour and kinetics of swelling, vapour permeability, dimension stability, their mechanical properties and cytotoxicity as well as their ability to control release properties were examined as a function of crosslinking density. It was found that however, all borax-induced-samples show acceptable biocompatibility, incorporation of 30% borax solution optimises their mechanical properties.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE BV
dc.relation.ispartof	Journal of the mechanical behavior of biomedical materials
dc.relation.isbasedon	10.1016/j.jmbbm.2016.09.008
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0903 Biomedical Engineering, 0912 Materials Engineering, 0913 Mechanical Engineering
dc.subject.classification	Biomedical Engineering
dc.subject.mesh	Humans
dc.subject.mesh	Borates
dc.subject.mesh	Starch
dc.subject.mesh	Gelatin
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Bandages
dc.subject.mesh	Wound Healing
dc.subject.mesh	Permeability
dc.subject.mesh	Bandages
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Borates
dc.subject.mesh	Gelatin
dc.subject.mesh	Humans
dc.subject.mesh	Permeability
dc.subject.mesh	Starch
dc.subject.mesh	Wound Healing
dc.title	Physico-mechanical, morphological and biomedical properties of a novel natural wound dressing material.
dc.type	Journal Article
utslib.citation.volume	65
utslib.location.activity	Netherlands
utslib.for	0903 Biomedical Engineering
utslib.for	0912 Materials Engineering
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-11-12T03:16:36Z
pubs.publication-status	Published
pubs.volume	65

Abstract:

Wound healing as a complex biological process greatly affects the quality of patients׳ lives. The high initial cost of wound treatment using advanced wound dressing is a major concern that warrants more attention. Because of the similarities between body macromolecules and polysaccharides and proteoglycans, gelatin and starch were used extensively as wound dressings; however their solubility in aqueous environment is known as a major drawback. Crosslinking, as a common method for enhancing mechanical properties, has its own limitation as some chemical cross-likers reduce biocompatibility. In this research, a simple and economical method for the fabrication of a novel wound dressing foam based on natural polymers of starch and gelatin with borax as the crosslinking agent is introduced. To evaluate the utility of the foams for wound dressing application, morphology, swelling behaviour and kinetics of swelling, vapour permeability, dimension stability, their mechanical properties and cytotoxicity as well as their ability to control release properties were examined as a function of crosslinking density. It was found that however, all borax-induced-samples show acceptable biocompatibility, incorporation of 30% borax solution optimises their mechanical properties.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/143940