Circulating tumour cell clusters: Insights into tumour dissemination and metastasis.

Herath, S; Razavi Bazaz, S; Monkman, J; Ebrahimi Warkiani, M; Richard, D; O'Byrne, K; Kulasinghe, A

Circulating tumour cell clusters: Insights into tumour dissemination and metastasis.

Herath, S Razavi Bazaz, S

Monkman, J Ebrahimi Warkiani, M

Richard, D O'Byrne, K Kulasinghe, A

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Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: Expert review of molecular diagnostics, 2020
Issue Date:: 2020-11-03

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Field	Value	Language
dc.contributor.author	Herath, S
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361
dc.contributor.author	Monkman, J
dc.contributor.author	Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944
dc.contributor.author	Richard, D
dc.contributor.author	O'Byrne, K
dc.contributor.author	Kulasinghe, A
dc.date.accessioned	2020-11-23T00:41:07Z
dc.date.available	2020-11-23T00:41:07Z
dc.date.issued	2020-11-03
dc.identifier.citation	Expert review of molecular diagnostics, 2020
dc.identifier.issn	1473-7159
dc.identifier.issn	1744-8352
dc.identifier.uri	http://hdl.handle.net/10453/144237
dc.description.abstract	INTRODUCTION:Metastasis results in more than 90% of cancer related deaths globally. The process is thought to be facilitated by metastatic precursor cells, commonly termed circulating tumour cells (CTCs). CTCs can exist as single cells or cell clusters and travel through the lymphovasculature to distant organs where they can form overt metastasis. Areas covered: Studies have highlighted that CTC clusters, which may be homotypic or heterotypic in composition, have a higher metastatic potential compared to single CTCs. The characterisation of CTC clusters is becoming important as heterotypic clusters can provide a mechanism for immune evasion. This review summarises the latest advances in CTC cluster mediated metastasis and clinical significance. Expert Opinion: Comprehensive characterisation of CTC clusters is needed to understand the cell types and interactions within clusters, in order to identify ways in which to reduce CTC cluster mediated metastasis. The role of CTC clusters in prognosticating disease progression needs to be determined by documenting CTC clusters from the time of diagnosis over the course of therapy.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Informa UK Limited
dc.relation.ispartof	Expert review of molecular diagnostics
dc.relation.isbasedon	10.1080/14737159.2020.1846523
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.rights	This is an Accepted Manuscript of an article published by Taylor & Francis in Expert review of molecular diagnostics, 2020 available online: http://www.tandfonline.com/doi/abs/10.1080/14737159.2020.1846523
dc.subject	1103 Clinical Sciences
dc.title	Circulating tumour cell clusters: Insights into tumour dissemination and metastasis.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2021-11-30T00:00:00+1000Z
dc.date.updated	2020-11-23T00:41:04Z
pubs.publication-status	Published

Abstract:

INTRODUCTION:Metastasis results in more than 90% of cancer related deaths globally. The process is thought to be facilitated by metastatic precursor cells, commonly termed circulating tumour cells (CTCs). CTCs can exist as single cells or cell clusters and travel through the lymphovasculature to distant organs where they can form overt metastasis. Areas covered: Studies have highlighted that CTC clusters, which may be homotypic or heterotypic in composition, have a higher metastatic potential compared to single CTCs. The characterisation of CTC clusters is becoming important as heterotypic clusters can provide a mechanism for immune evasion. This review summarises the latest advances in CTC cluster mediated metastasis and clinical significance. Expert Opinion: Comprehensive characterisation of CTC clusters is needed to understand the cell types and interactions within clusters, in order to identify ways in which to reduce CTC cluster mediated metastasis. The role of CTC clusters in prognosticating disease progression needs to be determined by documenting CTC clusters from the time of diagnosis over the course of therapy.

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http://hdl.handle.net/10453/144237