Using a second-person approach to identify disease-specific profiles of social behavior in frontotemporal dementia and Alzheimer's disease.

Visser, M; Wong, S; Simonetti, S; Hazelton, JL; Devenney, E; Ahmed, RM; van Langenhove, T; Parker, D; Burrell, JR; Hodges, JR; Kumfor, F

Using a second-person approach to identify disease-specific profiles of social behavior in frontotemporal dementia and Alzheimer's disease.

Visser, M

Wong, S Simonetti, S Hazelton, JL Devenney, E Ahmed, RM van Langenhove, T Parker, D

Burrell, JR Hodges, JR Kumfor, F

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Cortex; a journal devoted to the study of the nervous system and behavior, 2020, 133, pp. 236-246
Issue Date:: 2020-10-06

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Field	Value	Language
dc.contributor.author	Visser, M https://orcid.org/0000-0001-6796-6246
dc.contributor.author	Wong, S
dc.contributor.author	Simonetti, S
dc.contributor.author	Hazelton, JL
dc.contributor.author	Devenney, E
dc.contributor.author	Ahmed, RM
dc.contributor.author	van Langenhove, T
dc.contributor.author	Parker, D https://orcid.org/0000-0003-2552-8613
dc.contributor.author	Burrell, JR
dc.contributor.author	Hodges, JR
dc.contributor.author	Kumfor, F
dc.date.accessioned	2020-11-26T03:04:20Z
dc.date.available	2020-09-10
dc.date.available	2020-11-26T03:04:20Z
dc.date.issued	2020-10-06
dc.identifier.citation	Cortex; a journal devoted to the study of the nervous system and behavior, 2020, 133, pp. 236-246
dc.identifier.issn	0010-9452
dc.identifier.issn	1973-8102
dc.identifier.uri	http://hdl.handle.net/10453/144361
dc.description.abstract	Changes in social behavior are recognized as potential symptoms of behavioral-variant frontotemporal dementia (bvFTD) and semantic dementia (SD), yet objective ways to assess these behaviors in natural social situations are lacking. This study takes a truly social (or second-person) approach and examines changes in real-world social behavior in different dementia syndromes, by analyzing non-scripted social interactions in bvFTD patients (n = 20) and SD patients (n = 20), compared to patients with Alzheimer's disease (AD) (n = 20). Video recordings of 10-min conversations between patients and behavioral neurologists were analyzed for the presence of socially engaging (e.g., nodding, smiling, gesturing) and disengaging behavior (e.g., avoiding eye contact, self-grooming, interrupting). Results demonstrated disease-specific profiles, with bvFTD patients showing less nodding and more looking away than AD, and SD patients showing more gesturing than AD. A principal components analysis revealed the presence of four unobserved components, showing atypical disengaging patterns of behavior. Whole-brain voxel-based morphometry analyses revealed distinct neurobiological bases for each of these components, with the brain regions identified previously associated with behavior selection, abstract mentalization and processing of multi-sensory and socially-relevant information, in mediating socially engaging and disengaging behavior. This study demonstrates the utility of systematic behavioral observation of social interactions in the differential diagnosis of dementia.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Cortex; a journal devoted to the study of the nervous system and behavior
dc.relation.isbasedon	10.1016/j.cortex.2020.09.011
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
dc.subject.classification	Experimental Psychology
dc.title	Using a second-person approach to identify disease-specific profiles of social behavior in frontotemporal dementia and Alzheimer's disease.
dc.type	Journal Article
utslib.citation.volume	133
utslib.location.activity	Italy
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-11-26T03:04:16Z
pubs.publication-status	Published
pubs.volume	133

Abstract:

Changes in social behavior are recognized as potential symptoms of behavioral-variant frontotemporal dementia (bvFTD) and semantic dementia (SD), yet objective ways to assess these behaviors in natural social situations are lacking. This study takes a truly social (or second-person) approach and examines changes in real-world social behavior in different dementia syndromes, by analyzing non-scripted social interactions in bvFTD patients (n = 20) and SD patients (n = 20), compared to patients with Alzheimer's disease (AD) (n = 20). Video recordings of 10-min conversations between patients and behavioral neurologists were analyzed for the presence of socially engaging (e.g., nodding, smiling, gesturing) and disengaging behavior (e.g., avoiding eye contact, self-grooming, interrupting). Results demonstrated disease-specific profiles, with bvFTD patients showing less nodding and more looking away than AD, and SD patients showing more gesturing than AD. A principal components analysis revealed the presence of four unobserved components, showing atypical disengaging patterns of behavior. Whole-brain voxel-based morphometry analyses revealed distinct neurobiological bases for each of these components, with the brain regions identified previously associated with behavior selection, abstract mentalization and processing of multi-sensory and socially-relevant information, in mediating socially engaging and disengaging behavior. This study demonstrates the utility of systematic behavioral observation of social interactions in the differential diagnosis of dementia.

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http://hdl.handle.net/10453/144361