Colonic malakoplakia in a dual stem cell and cardiac transplant recipient: A case report and literature review.

Meredith, T; Dharan, N; Killen, L; Anandabaskaran, S; Kim, A; Yang, T; Marriott, D; Hayward, C; Macdonald, P

Colonic malakoplakia in a dual stem cell and cardiac transplant recipient: A case report and literature review.

Meredith, T Dharan, N Killen, L Anandabaskaran, S Kim, A Yang, T Marriott, D Hayward, C Macdonald, P

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Transplant infectious disease : an official journal of the Transplantation Society, 2020, pp. e13488
Issue Date:: 2020-10-09

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Field	Value	Language
dc.contributor.author	Meredith, T
dc.contributor.author	Dharan, N
dc.contributor.author	Killen, L
dc.contributor.author	Anandabaskaran, S
dc.contributor.author	Kim, A
dc.contributor.author	Yang, T
dc.contributor.author	Marriott, D
dc.contributor.author	Hayward, C
dc.contributor.author	Macdonald, P https://orcid.org/0000-0001-5378-2825
dc.date.accessioned	2020-12-10T02:47:59Z
dc.date.available	2020-10-04
dc.date.available	2020-12-10T02:47:59Z
dc.date.issued	2020-10-09
dc.identifier.citation	Transplant infectious disease : an official journal of the Transplantation Society, 2020, pp. e13488
dc.identifier.issn	1398-2273
dc.identifier.issn	1399-3062
dc.identifier.uri	http://hdl.handle.net/10453/144612
dc.description.abstract	We describe the first published case of malakoplakia in a dual stem cell and cardiac transplant recipient. In the 2 months following cardiac transplantation, our patient developed persistent diarrhea and recurrent E coli bacteremia. Biopsies obtained from areas of colonic thickening revealed malakoplakia. Despite improvement in symptoms with prolonged antimicrobial therapy and reduction of his immunosuppression, he eventually died from sepsis. Our case highlights not only the importance of the timely diagnosis of this rare disorder, but also the difficulty in determining optimal treatment duration, particularly where excision of involved areas is not possible, as data on this disease are lacking. Here we describe our case and review the available literature published on malakoplakia in the cardiac transplant population.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Transplant infectious disease : an official journal of the Transplantation Society
dc.relation.isbasedon	10.1111/tid.13488
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1103 Clinical Sciences
dc.subject.classification	Surgery
dc.title	Colonic malakoplakia in a dual stem cell and cardiac transplant recipient: A case report and literature review.
dc.type	Journal Article
utslib.location.activity	Denmark
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-12-10T02:47:55Z
pubs.publication-status	Published

Abstract:

We describe the first published case of malakoplakia in a dual stem cell and cardiac transplant recipient. In the 2 months following cardiac transplantation, our patient developed persistent diarrhea and recurrent E coli bacteremia. Biopsies obtained from areas of colonic thickening revealed malakoplakia. Despite improvement in symptoms with prolonged antimicrobial therapy and reduction of his immunosuppression, he eventually died from sepsis. Our case highlights not only the importance of the timely diagnosis of this rare disorder, but also the difficulty in determining optimal treatment duration, particularly where excision of involved areas is not possible, as data on this disease are lacking. Here we describe our case and review the available literature published on malakoplakia in the cardiac transplant population.

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http://hdl.handle.net/10453/144612