Point of Care Diagnostics in the Age of COVID-19.

Rezaei, M; Razavi Bazaz, S; Zhand, S; Sayyadi, N; Jin, D; Stewart, MP; Ebrahimi Warkiani, M

Point of Care Diagnostics in the Age of COVID-19.

Rezaei, M Razavi Bazaz, S

Zhand, S Sayyadi, N Jin, D

Stewart, MP Ebrahimi Warkiani, M

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Diagnostics (Basel, Switzerland), 2020, 11, (1), pp. 9-9
Issue Date:: 2020-12-23

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Field	Value	Language
dc.contributor.author	Rezaei, M
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361
dc.contributor.author	Zhand, S
dc.contributor.author	Sayyadi, N
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Stewart, MP
dc.contributor.author	Ebrahimi Warkiani, M
dc.date.accessioned	2021-01-12T05:32:16Z
dc.date.available	2020-12-20
dc.date.available	2021-01-12T05:32:16Z
dc.date.issued	2020-12-23
dc.identifier.citation	Diagnostics (Basel, Switzerland), 2020, 11, (1), pp. 9-9
dc.identifier.issn	2075-4418
dc.identifier.issn	2075-4418
dc.identifier.uri	http://hdl.handle.net/10453/145342
dc.description.abstract	The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated serious respiratory disease, coronavirus disease 2019 (COVID-19), poses a major threat to global public health. Owing to the lack of vaccine and effective treatments, many countries have been overwhelmed with an exponential spread of the virus and surge in the number of confirmed COVID-19 cases. Current standard diagnostic methods are inadequate for widespread testing as they suffer from prolonged turn-around times (>12 h) and mostly rely on high-biosafety-level laboratories and well-trained technicians. Point-of-care (POC) tests have the potential to vastly improve healthcare in several ways, ranging from enabling earlier detection and easier monitoring of disease to reaching remote populations. In recent years, the field of POC diagnostics has improved markedly with the advent of micro- and nanotechnologies. Due to the COVID-19 pandemic, POC technologies have been rapidly innovated to address key limitations faced in existing standard diagnostic methods. This review summarizes and compares the latest available POC immunoassay, nucleic acid-based and clustered regularly interspaced short palindromic repeats- (CRISPR)-mediated tests for SARS-CoV-2 detection that we anticipate aiding healthcare facilities to control virus infection and prevent subsequent spread.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	Diagnostics (Basel, Switzerland)
dc.relation.isbasedon	10.3390/diagnostics11010009
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Point of Care Diagnostics in the Age of COVID-19.
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2021-01-12T05:32:11Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	11
utslib.citation.issue	1

Abstract:

The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated serious respiratory disease, coronavirus disease 2019 (COVID-19), poses a major threat to global public health. Owing to the lack of vaccine and effective treatments, many countries have been overwhelmed with an exponential spread of the virus and surge in the number of confirmed COVID-19 cases. Current standard diagnostic methods are inadequate for widespread testing as they suffer from prolonged turn-around times (>12 h) and mostly rely on high-biosafety-level laboratories and well-trained technicians. Point-of-care (POC) tests have the potential to vastly improve healthcare in several ways, ranging from enabling earlier detection and easier monitoring of disease to reaching remote populations. In recent years, the field of POC diagnostics has improved markedly with the advent of micro- and nanotechnologies. Due to the COVID-19 pandemic, POC technologies have been rapidly innovated to address key limitations faced in existing standard diagnostic methods. This review summarizes and compares the latest available POC immunoassay, nucleic acid-based and clustered regularly interspaced short palindromic repeats- (CRISPR)-mediated tests for SARS-CoV-2 detection that we anticipate aiding healthcare facilities to control virus infection and prevent subsequent spread.

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http://hdl.handle.net/10453/145342