Valuing the AD-5D Dementia Utility Instrument: An Estimation of a General Population Tariff.

Comans, TA; Nguyen, K-H; Ratcliffe, J; Rowen, D; Mulhern, B

Valuing the AD-5D Dementia Utility Instrument: An Estimation of a General Population Tariff.

Comans, TA Nguyen, K-H Ratcliffe, J Rowen, D Mulhern, B

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: PharmacoEconomics, 2020, 38, (8), pp. 871-881
Issue Date:: 2020-08

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Field	Value	Language
dc.contributor.author	Comans, TA
dc.contributor.author	Nguyen, K-H
dc.contributor.author	Ratcliffe, J
dc.contributor.author	Rowen, D
dc.contributor.author	Mulhern, B https://orcid.org/0000-0003-3656-8063
dc.date.accessioned	2021-02-04T23:48:13Z
dc.date.available	2021-02-04T23:48:13Z
dc.date.issued	2020-08
dc.identifier.citation	PharmacoEconomics, 2020, 38, (8), pp. 871-881
dc.identifier.issn	1170-7690
dc.identifier.issn	1179-2027
dc.identifier.uri	http://hdl.handle.net/10453/145856
dc.description.abstract	<h4>Objective</h4>This paper reports on the valuation of quality-of-life states in the Alzheimer's Disease Five Dimensions (AD-5D) instrument in a representative sample of the general population in Australia using the discrete-choice experiment with duration (DCE<sub>TTO</sub>) elicitation technique.<h4>Method</h4>A DCE with 200 choice sets of two quality-of-life (QoL) state-duration combinations blocked into 20 survey versions, with ten choice sets in each version, was designed and administered online to a sample representative of the Australian population. Two additional choice sets comprising internal consistency and dominance checks were included in each survey version. A range of model specifications investigating preferences with respect to duration and interactions between AD-5D dimension levels were estimated. Utility weights were developed, with estimated coefficients transformed to the 0 (being dead) to 1 (full health) scale, suitable for the calculation of quality-adjusted life-year (QALY) weights for use in economic evaluation.<h4>Results</h4>In total, 1999 respondents completed the choice experiment. Overall, respondents were slightly better educated and had higher annual incomes than the Australian general population. The estimation results from different specifications and models were broadly consistent with the monotonic nature of the AD-5D: utility increased with increased life expectancy and decreased as the severity level for each dimension worsened. A utility value set was generated for the calculation of utilities for all QoL states defined by the AD-5D descriptive system.<h4>Conclusion</h4>The DCE-based utility value set is now available to use to generate QALYs for the economic evaluation of treatments and interventions targeting people with dementia and/or their family caregivers.
dc.format	Print
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation	http://purl.org/au-research/grants/nhmrc/
dc.relation	http://purl.org/au-research/grants/nhmrc/9100000
dc.relation.ispartof	PharmacoEconomics
dc.relation.isbasedon	10.1007/s40273-020-00913-7
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	11 Medical and Health Sciences, 14 Economics
dc.subject.classification	Health Policy & Services
dc.title	Valuing the AD-5D Dementia Utility Instrument: An Estimation of a General Population Tariff.
dc.type	Journal Article
utslib.citation.volume	38
utslib.location.activity	New Zealand
utslib.for	11 Medical and Health Sciences
utslib.for	14 Economics
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2021-02-04T23:47:49Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	38
utslib.citation.issue	8

Abstract:

Objective

This paper reports on the valuation of quality-of-life states in the Alzheimer's Disease Five Dimensions (AD-5D) instrument in a representative sample of the general population in Australia using the discrete-choice experiment with duration (DCE_TTO) elicitation technique.

Method

A DCE with 200 choice sets of two quality-of-life (QoL) state-duration combinations blocked into 20 survey versions, with ten choice sets in each version, was designed and administered online to a sample representative of the Australian population. Two additional choice sets comprising internal consistency and dominance checks were included in each survey version. A range of model specifications investigating preferences with respect to duration and interactions between AD-5D dimension levels were estimated. Utility weights were developed, with estimated coefficients transformed to the 0 (being dead) to 1 (full health) scale, suitable for the calculation of quality-adjusted life-year (QALY) weights for use in economic evaluation.

Results

In total, 1999 respondents completed the choice experiment. Overall, respondents were slightly better educated and had higher annual incomes than the Australian general population. The estimation results from different specifications and models were broadly consistent with the monotonic nature of the AD-5D: utility increased with increased life expectancy and decreased as the severity level for each dimension worsened. A utility value set was generated for the calculation of utilities for all QoL states defined by the AD-5D descriptive system.

Conclusion

The DCE-based utility value set is now available to use to generate QALYs for the economic evaluation of treatments and interventions targeting people with dementia and/or their family caregivers.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/145856