Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.

Ling, T; Li, JJ; Xu, R-J; Wang, B; Ge, W-H

Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.

Ling, T Li, JJ Xu, R-J Wang, B Ge, W-H

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Publisher:: HINDAWI LTD
Publication Type:: Journal Article
Citation:: BioMed research international, 2020, 2020
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Ling, T
dc.contributor.author	Li, JJ
dc.contributor.author	Xu, R-J
dc.contributor.author	Wang, B
dc.contributor.author	Ge, W-H
dc.date.accessioned	2021-02-10T02:30:18Z
dc.date.available	2020-11-07
dc.date.available	2021-02-10T02:30:18Z
dc.date.issued	2020-01
dc.identifier.citation	BioMed research international, 2020, 2020
dc.identifier.issn	2314-6133
dc.identifier.issn	2314-6141
dc.identifier.uri	http://hdl.handle.net/10453/146012
dc.description.abstract	This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subscales, pain on walking, and the occurrence of adverse events were pooled to comprehensively analyse the efficacy and safety of topical diclofenac solution. All statistical analyses were conducted using Review Manager 5.3 software. Five RCTs were included, which provided high-quality evidence. In comparison to the vehicle control, the mean differences for WOMAC pain, stiffness, and physical function subscales, as well as pain on walking, were all statistically significant in favor of topical diclofenac solution. The safety of topical diclofenac solution was similar to the vehicle control, apart from adverse events involving application-site skin reactions. Topical diclofenac solution is effective and safe for use in patients with knee OA, but may cause minor skin reactions.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	HINDAWI LTD
dc.relation	http://purl.org/au-research/grants/nhmrc/1120249
dc.relation.ispartof	BioMed research international
dc.relation.isbasedon	10.1155/2020/1758071
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	06 Biological Sciences, 08 Information and Computing Sciences, 10 Technology
dc.title	Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.
dc.type	Journal Article
utslib.citation.volume	2020
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	08 Information and Computing Sciences
utslib.for	10 Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-02-10T02:30:04Z
pubs.publication-status	Published
pubs.volume	2020

Abstract:

This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subscales, pain on walking, and the occurrence of adverse events were pooled to comprehensively analyse the efficacy and safety of topical diclofenac solution. All statistical analyses were conducted using Review Manager 5.3 software. Five RCTs were included, which provided high-quality evidence. In comparison to the vehicle control, the mean differences for WOMAC pain, stiffness, and physical function subscales, as well as pain on walking, were all statistically significant in favor of topical diclofenac solution. The safety of topical diclofenac solution was similar to the vehicle control, apart from adverse events involving application-site skin reactions. Topical diclofenac solution is effective and safe for use in patients with knee OA, but may cause minor skin reactions.

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http://hdl.handle.net/10453/146012