Key MicroRNA's and Their Targetome in Adrenocortical Cancer.

Chehade, M; Bullock, M; Glover, A; Hutvagner, G; Sidhu, S

Key MicroRNA's and Their Targetome in Adrenocortical Cancer.

Chehade, M Bullock, M Glover, A Hutvagner, G

Sidhu, S

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Cancers, 2020, 12, (8), pp. 1-23
Issue Date:: 2020-08-06

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Field	Value	Language
dc.contributor.author	Chehade, M
dc.contributor.author	Bullock, M
dc.contributor.author	Glover, A
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446
dc.contributor.author	Sidhu, S
dc.date.accessioned	2021-02-24T21:05:48Z
dc.date.available	2020-07-28
dc.date.available	2021-02-24T21:05:48Z
dc.date.issued	2020-08-06
dc.identifier.citation	Cancers, 2020, 12, (8), pp. 1-23
dc.identifier.issn	2072-6694
dc.identifier.issn	2072-6694
dc.identifier.uri	http://hdl.handle.net/10453/146416
dc.description.abstract	Adrenocortical Carcinoma (ACC) is a rare but aggressive malignancy with poor prognosis and limited response to available systemic therapies. Although complete surgical resection gives the best chance for long-term survival, ACC has a two-year recurrence rate of 50%, which poses a therapeutic challenge. High throughput analyses focused on characterizing the molecular signature of ACC have revealed specific micro-RNAs (miRNAs) that are associated with aggressive tumor phenotypes. MiRNAs are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation or degrading mRNA transcripts and have been generally implicated in carcinogenesis. This review summarizes the current insights into dysregulated miRNAs in ACC tumorigenesis, their known functions, and specific targetomes. In addition, we explore the possibility of particular miRNAs to be exploited as clinical biomarkers in ACC and as potential therapeutics.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Cancers
dc.relation.isbasedon	10.3390/cancers12082198
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights	©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0
dc.subject	1112 Oncology and Carcinogenesis
dc.title	Key MicroRNA's and Their Targetome in Adrenocortical Cancer.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	Switzerland
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	recently_added	*
dc.date.updated	2021-02-24T21:05:42Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	8

Abstract:

Adrenocortical Carcinoma (ACC) is a rare but aggressive malignancy with poor prognosis and limited response to available systemic therapies. Although complete surgical resection gives the best chance for long-term survival, ACC has a two-year recurrence rate of 50%, which poses a therapeutic challenge. High throughput analyses focused on characterizing the molecular signature of ACC have revealed specific micro-RNAs (miRNAs) that are associated with aggressive tumor phenotypes. MiRNAs are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation or degrading mRNA transcripts and have been generally implicated in carcinogenesis. This review summarizes the current insights into dysregulated miRNAs in ACC tumorigenesis, their known functions, and specific targetomes. In addition, we explore the possibility of particular miRNAs to be exploited as clinical biomarkers in ACC and as potential therapeutics.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/146416