Withaferin A activates TRIM16 for its anti-cancer activity in melanoma.

Nagy, Z; Cheung, BB; Tsang, W; Tan, O; Herath, M; Ciampa, OC; Shadma, F; Carter, DR; Marshall, GM

Withaferin A activates TRIM16 for its anti-cancer activity in melanoma.

Nagy, Z Cheung, BB Tsang, W Tan, O Herath, M Ciampa, OC Shadma, F Carter, DR Marshall, GM

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Scientific reports, 2020, 10, (1)
Issue Date:: 2020-11-12

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Field	Value	Language
dc.contributor.author	Nagy, Z
dc.contributor.author	Cheung, BB
dc.contributor.author	Tsang, W
dc.contributor.author	Tan, O
dc.contributor.author	Herath, M
dc.contributor.author	Ciampa, OC
dc.contributor.author	Shadma, F
dc.contributor.author	Carter, DR
dc.contributor.author	Marshall, GM
dc.date.accessioned	2021-03-01T05:35:50Z
dc.date.available	2020-10-29
dc.date.available	2021-03-01T05:35:50Z
dc.date.issued	2020-11-12
dc.identifier.citation	Scientific reports, 2020, 10, (1)
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/146566
dc.description.abstract	Although selective BRAF inhibitors and novel immunotherapies have improved short-term treatment responses in metastatic melanoma patients, acquired resistance to these therapeutics still represent a major challenge in clinical practice. In this study, we evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma. WFA showed selective toxicity to melanoma cells compared to non-malignant cells. WFA induced apoptosis, significantly reduced cell proliferation and inhibited migration of melanoma cells. We identified that repression of the tumour suppressor TRIM16 diminished WFA cytotoxicity, suggesting that TRIM16 was in part responsible for the cytotoxic effects of WFA in melanoma cells. Together our data indicates that WFA has potent cytopathic effects on melanoma cells through TRIM16, suggesting a potential therapeutic application of WFA in the disease.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Scientific reports
dc.relation.isbasedon	10.1038/s41598-020-76722-x
dc.rights	This is a post-peer-review, pre-copyedit version of an article published in Scientific reports. The final authenticated version is available online at: https://dx.doi.org/10.1038/s41598-020-76722-x.	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Withaferin A activates TRIM16 for its anti-cancer activity in melanoma.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-03-01T05:35:45Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	10
utslib.citation.issue	1

Abstract:

Although selective BRAF inhibitors and novel immunotherapies have improved short-term treatment responses in metastatic melanoma patients, acquired resistance to these therapeutics still represent a major challenge in clinical practice. In this study, we evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma. WFA showed selective toxicity to melanoma cells compared to non-malignant cells. WFA induced apoptosis, significantly reduced cell proliferation and inhibited migration of melanoma cells. We identified that repression of the tumour suppressor TRIM16 diminished WFA cytotoxicity, suggesting that TRIM16 was in part responsible for the cytotoxic effects of WFA in melanoma cells. Together our data indicates that WFA has potent cytopathic effects on melanoma cells through TRIM16, suggesting a potential therapeutic application of WFA in the disease.

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http://hdl.handle.net/10453/146566