The influence of mental fatigue on brain activity: Evidence from a systematic review with meta-analyses.

Tran, Y; Craig, A; Craig, R; Chai, R; Nguyen, H

The influence of mental fatigue on brain activity: Evidence from a systematic review with meta-analyses.

Tran, Y Craig, A Craig, R Chai, R

Nguyen, H

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Psychophysiology, 2020, 57, (5)
Issue Date:: 2020-05

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Field	Value	Language
dc.contributor.author	Tran, Y
dc.contributor.author	Craig, A
dc.contributor.author	Craig, R
dc.contributor.author	Chai, R https://orcid.org/0000-0002-1922-7024
dc.contributor.author	Nguyen, H
dc.date.accessioned	2021-03-05T02:06:42Z
dc.date.available	2020-02-10
dc.date.available	2021-03-05T02:06:42Z
dc.date.issued	2020-05
dc.identifier.citation	Psychophysiology, 2020, 57, (5)
dc.identifier.issn	0048-5772
dc.identifier.issn	1540-5958
dc.identifier.uri	http://hdl.handle.net/10453/146799
dc.description.abstract	The occurrence of mental fatigue during tasks like driving a vehicle increases risk of injury or death. Changes in electroencephalographic (EEG) activity associated with mental fatigue has been frequently studied and considered a promising biomarker of mental fatigue. This is despite differences in methodologies and outcomes in prior research. A systematic review with meta-analyses was conducted to establish the influence of mental fatigue on EEG activity spectral bands, and to determine in which regions fatigue-related EEG spectral changes are likely to occur. A high-yield search strategy identified 21 studies meeting inclusion criteria for investigating the change in EEG spectral activity in non-diseased adults engaged in mentally fatiguing tasks. A medium effect size (using Cohen's g) of 0.68 (95%CI: 0.24-1.13) was found for increase in overall EEG activity following mental fatigue. Further examination of individual EEG spectral bands and regions using network meta-analyses indicated large increases in theta (g = 1.03; 95%CI: 0.79-1.60) and alpha bands (g = 0.85; 95%CI: 0.47-1.43), with small to moderate changes found in delta and beta bands. Central regions of the scalp showed largest change (g = 0.80; 95%CI: 0.46-1.21). Sub-group analyses indicated large increases in theta activity in frontal, central and posterior sites (all g > 1), with moderate changes in alpha activity in central and posterior sites. Findings have implications for fatigue monitoring and countermeasures with support for change in theta activity in frontal, central and posterior sites as a robust biomarker of mental fatigue and change in alpha wave activity considered a second line biomarker to account for individual variability.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation	http://purl.org/au-research/grants/arc/DP150102493
dc.relation.ispartof	Psychophysiology
dc.relation.isbasedon	10.1111/psyp.13554
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Experimental Psychology
dc.title	The influence of mental fatigue on brain activity: Evidence from a systematic review with meta-analyses.
dc.type	Journal Article
utslib.citation.volume	57
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-03-05T02:06:40Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	57
utslib.citation.issue	5

Abstract:

The occurrence of mental fatigue during tasks like driving a vehicle increases risk of injury or death. Changes in electroencephalographic (EEG) activity associated with mental fatigue has been frequently studied and considered a promising biomarker of mental fatigue. This is despite differences in methodologies and outcomes in prior research. A systematic review with meta-analyses was conducted to establish the influence of mental fatigue on EEG activity spectral bands, and to determine in which regions fatigue-related EEG spectral changes are likely to occur. A high-yield search strategy identified 21 studies meeting inclusion criteria for investigating the change in EEG spectral activity in non-diseased adults engaged in mentally fatiguing tasks. A medium effect size (using Cohen's g) of 0.68 (95%CI: 0.24-1.13) was found for increase in overall EEG activity following mental fatigue. Further examination of individual EEG spectral bands and regions using network meta-analyses indicated large increases in theta (g = 1.03; 95%CI: 0.79-1.60) and alpha bands (g = 0.85; 95%CI: 0.47-1.43), with small to moderate changes found in delta and beta bands. Central regions of the scalp showed largest change (g = 0.80; 95%CI: 0.46-1.21). Sub-group analyses indicated large increases in theta activity in frontal, central and posterior sites (all g > 1), with moderate changes in alpha activity in central and posterior sites. Findings have implications for fatigue monitoring and countermeasures with support for change in theta activity in frontal, central and posterior sites as a robust biomarker of mental fatigue and change in alpha wave activity considered a second line biomarker to account for individual variability.

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http://hdl.handle.net/10453/146799