Exercise intervention and sexual function in advanced prostate cancer: a randomised controlled trial.

Galvão, DA; Taaffe, DR; Chambers, SK; Fairman, CM; Spry, N; Joseph, D; Newton, RU

Exercise intervention and sexual function in advanced prostate cancer: a randomised controlled trial.

Galvão, DA Taaffe, DR Chambers, SK Fairman, CM Spry, N Joseph, D Newton, RU

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Publisher:: BMJ
Publication Type:: Journal Article
Citation:: BMJ supportive & palliative care, 2020, pp. bmjspcare-2020-002706
Issue Date:: 2020-12-16

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Field	Value	Language
dc.contributor.author	Galvão, DA
dc.contributor.author	Taaffe, DR
dc.contributor.author	Chambers, SK
dc.contributor.author	Fairman, CM
dc.contributor.author	Spry, N
dc.contributor.author	Joseph, D
dc.contributor.author	Newton, RU
dc.date.accessioned	2021-03-07T02:45:22Z
dc.date.available	2020-11-30
dc.date.available	2021-03-07T02:45:22Z
dc.date.issued	2020-12-16
dc.identifier.citation	BMJ supportive & palliative care, 2020, pp. bmjspcare-2020-002706
dc.identifier.issn	2045-435X
dc.identifier.issn	2045-4368
dc.identifier.uri	http://hdl.handle.net/10453/146835
dc.description.abstract	<h4>Objectives</h4>Treatments for prostate cancer such as androgen deprivation therapy (ADT), surgery and radiation therapy can adversely affect sexual, urinary and bowel function. Preliminary research has demonstrated the efficacy of exercise to preserve sexual function in men with localised prostate cancer receiving ADT, though this has yet to be investigated in a metastatic setting. We examined the effects of a 12-week exercise programme comprising resistance, aerobic and flexibility training on sexual health and function in men with advanced prostate cancer.<h4>Methods</h4>Patients with prostate cancer (70.0±8.4 year; body mass index 28.7±4.0 kg/m<sup>2</sup>) with bone metastases (rib/thoracic spine, 66.7%; lumbar spine, 43.9%; pelvis, 75.4%; femur, 40.4%; humerus, 24.6%; other sites, 70.2%) were randomly assigned to supervised exercise 3 days/week (n=28) or usual care (n=29). Sexual health and function were assessed using the International Index of Erectile Function, the Expanded Prostate Cancer Index Composite and the EORTC-PR25 at baseline and 12 weeks.<h4>Results</h4>Patients attended 89% of planned sessions and there were no adverse events. After adjusting for baseline values, there was no significant difference between groups for any measure of sexual function and activity (p>0.05). Additionally, there was no significant difference between groups for urinary and bowel function assessed by the EORTC-PR25 (p>0.05).<h4>Conclusions</h4>A short-term programme of supervised exercise does not appear to enhance indices of sexual health and function in men with advanced prostate cancer. Limitations of the intervention included the conservative modular exercise programme, which deliberately avoided loading bone metastatic sites.<h4>Trial registration number</h4>ACTRN12611001158954.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	BMJ
dc.relation.ispartof	BMJ supportive & palliative care
dc.relation.isbasedon	10.1136/bmjspcare-2020-002706
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1110 Nursing, 1117 Public Health and Health Services
dc.title	Exercise intervention and sexual function in advanced prostate cancer: a randomised controlled trial.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1110 Nursing
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2021-03-07T02:45:19Z
pubs.publication-status	Published

Abstract:

Objectives

Treatments for prostate cancer such as androgen deprivation therapy (ADT), surgery and radiation therapy can adversely affect sexual, urinary and bowel function. Preliminary research has demonstrated the efficacy of exercise to preserve sexual function in men with localised prostate cancer receiving ADT, though this has yet to be investigated in a metastatic setting. We examined the effects of a 12-week exercise programme comprising resistance, aerobic and flexibility training on sexual health and function in men with advanced prostate cancer.

Methods

Patients with prostate cancer (70.0±8.4 year; body mass index 28.7±4.0 kg/m²) with bone metastases (rib/thoracic spine, 66.7%; lumbar spine, 43.9%; pelvis, 75.4%; femur, 40.4%; humerus, 24.6%; other sites, 70.2%) were randomly assigned to supervised exercise 3 days/week (n=28) or usual care (n=29). Sexual health and function were assessed using the International Index of Erectile Function, the Expanded Prostate Cancer Index Composite and the EORTC-PR25 at baseline and 12 weeks.

Results

Patients attended 89% of planned sessions and there were no adverse events. After adjusting for baseline values, there was no significant difference between groups for any measure of sexual function and activity (p>0.05). Additionally, there was no significant difference between groups for urinary and bowel function assessed by the EORTC-PR25 (p>0.05).

Conclusions

A short-term programme of supervised exercise does not appear to enhance indices of sexual health and function in men with advanced prostate cancer. Limitations of the intervention included the conservative modular exercise programme, which deliberately avoided loading bone metastatic sites.

Trial registration number

ACTRN12611001158954.

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http://hdl.handle.net/10453/146835