Omentum support for cardiac regeneration in ischaemic cardiomyopathy models: a systematic scoping review.

Wang, H; Roche, CD; Gentile, C

Omentum support for cardiac regeneration in ischaemic cardiomyopathy models: a systematic scoping review.

Wang, H Roche, CD Gentile, C

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Publisher:: OXFORD UNIV PRESS INC
Publication Type:: Journal Article
Citation:: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2020, 58, (6), pp. 1118-1129
Issue Date:: 2020-12

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Field	Value	Language
dc.contributor.author	Wang, H
dc.contributor.author	Roche, CD
dc.contributor.author	Gentile, C https://orcid.org/0000-0002-3689-4275
dc.date.accessioned	2021-03-21T21:16:39Z
dc.date.available	2020-05-09
dc.date.available	2021-03-21T21:16:39Z
dc.date.issued	2020-12
dc.identifier.citation	European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2020, 58, (6), pp. 1118-1129
dc.identifier.issn	1010-7940
dc.identifier.issn	1873-734X
dc.identifier.uri	http://hdl.handle.net/10453/147418
dc.description.abstract	<h4>Objectives</h4>Preclinical in vivo studies using omental tissue as a biomaterial for myocardial regeneration are promising and have not previously been collated. We aimed to evaluate the effects of the omentum as a support for bioengineered tissue therapy for cardiac regeneration in vivo.<h4>Methods</h4>A systematic scoping review was performed. Only English-language studies that used bioengineered cardio-regenerative tissue, omentum and ischaemic cardiomyopathy in vivo models were included.<h4>Results</h4>We initially screened 1926 studies of which 17 were included in the final qualitative analysis. Among these, 11 were methodologically comparable and 6 were non-comparable. The use of the omentum improved the engraftment of bioengineered tissue by improving cell retention and reducing infarct size. Vascularization was also improved by the induction of angiogenesis in the transplanted tissue. Omentum-supported bioengineered grafts were associated with enhanced host reverse remodelling and improved haemodynamic measurements.<h4>Conclusions</h4>The omentum is a promising support for myocardial regenerative bioengineering in vivo. Future studies would benefit from more homogenous methodologies and reporting of outcomes to allow for direct comparison.
dc.format	Print
dc.language	eng
dc.publisher	OXFORD UNIV PRESS INC
dc.relation.ispartof	European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
dc.relation.isbasedon	10.1093/ejcts/ezaa205
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology
dc.subject.classification	Respiratory System
dc.title	Omentum support for cardiac regeneration in ischaemic cardiomyopathy models: a systematic scoping review.
dc.type	Journal Article
utslib.citation.volume	58
utslib.location.activity	Germany
utslib.for	1102 Cardiorespiratory Medicine and Haematology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-03-21T21:16:36Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	58
utslib.citation.issue	6

Abstract:

Objectives

Preclinical in vivo studies using omental tissue as a biomaterial for myocardial regeneration are promising and have not previously been collated. We aimed to evaluate the effects of the omentum as a support for bioengineered tissue therapy for cardiac regeneration in vivo.

Methods

A systematic scoping review was performed. Only English-language studies that used bioengineered cardio-regenerative tissue, omentum and ischaemic cardiomyopathy in vivo models were included.

Results

We initially screened 1926 studies of which 17 were included in the final qualitative analysis. Among these, 11 were methodologically comparable and 6 were non-comparable. The use of the omentum improved the engraftment of bioengineered tissue by improving cell retention and reducing infarct size. Vascularization was also improved by the induction of angiogenesis in the transplanted tissue. Omentum-supported bioengineered grafts were associated with enhanced host reverse remodelling and improved haemodynamic measurements.

Conclusions

The omentum is a promising support for myocardial regenerative bioengineering in vivo. Future studies would benefit from more homogenous methodologies and reporting of outcomes to allow for direct comparison.

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http://hdl.handle.net/10453/147418