Characterization of the scatter component in large axial field-of-view PET scanners: A Monte Carlo simulation study

Ghabrial, A; Franklin, D; Zaidi, H

Characterization of the scatter component in large axial field-of-view PET scanners: A Monte Carlo simulation study

Ghabrial, A Franklin, D

Zaidi, H

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Publisher:: IEEE
Publication Type:: Conference Proceeding
Citation:: 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings, 2018, 00, pp. 1-3
Issue Date:: 2018-11-01

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Field	Value	Language
dc.contributor.author	Ghabrial, A
dc.contributor.author	Franklin, D https://orcid.org/0000-0002-9563-5943
dc.contributor.author	Zaidi, H
dc.date	2018-11-10
dc.date.accessioned	2021-03-25T22:25:08Z
dc.date.available	2021-03-25T22:25:08Z
dc.date.issued	2018-11-01
dc.identifier.citation	2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings, 2018, 00, pp. 1-3
dc.identifier.isbn	9781538684948
dc.identifier.uri	http://hdl.handle.net/10453/147539
dc.description.abstract	© 2018 IEEE. A simulation study was conducted to estimate the scatter fraction (SF) and to determine the most suitable line source radial offset displacement required to measure the SF for the total body long axial field-of-view (LAFOV) PET scanner by simulating different cylindrical and anthropomorphic digital phantoms. Simulations are conducted using a scanner model together with scatter phantoms adapted from the NEMA NU-2 2007 scatter phantom design, modified to suit the dimensions of the respective scanners, with line sources of various activities placed at a 45 mm radial offset. SF estimates obtained using the NEMA protocol are compared to values obtained with uniformly filled water phantom of the same length. A whole-body study is conducted using a set of 12 anthropomorphic phantoms with different BMIs, with different organs and anatomical structures filled with realistic concentrations of 18F-FDG. The SF obtained at 45 mm radial offset using 1 kBq/ml with the 200 cm (LAFOV scanner) and 70 cm (mCT) cylindrical phantoms are 40.07% and 34.35%, respectively. In both cases, a comparison with the SF estimate obtained with a uniformly filled cylindrical phantom shows that the NEMA NU2-2007 phantom with the line source positioned at the recommended radial offset of 45 mm significantly overestimates the SF. Instead, it was found that for both scanners, the optimal radial offset for accurate estimation of the SF was approximately 60 mm. High SF correlation coefficients were obtained between the SFs estimated with anthropomorphic phantoms with realistic biodistribution of 18F-FDG and an equivalent volume cylindrical phantom for the LAFOV PET scanner; in addition, BMI was strongly positively correlated with SF. The SF is found to be higher for the LAFOV compared with the mCT PET scanner. The optimal radial displacement for a LAFOV PET scanner using a NEMA-like phantom was found to be 60 mm, compared to the value of 45 mm suggested by the NEMA protocol.
dc.language	en
dc.publisher	IEEE
dc.relation.ispartof	2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
dc.relation.ispartof	2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
dc.relation.isbasedon	10.1109/NSSMIC.2018.8824762
dc.rights	© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Characterization of the scatter component in large axial field-of-view PET scanners: A Monte Carlo simulation study
dc.type	Conference Proceeding
utslib.citation.volume	00
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CRIN - Realtime Information Networks
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-03-25T22:25:04Z
pubs.finish-date	2018-11-17
pubs.publication-status	Published
pubs.start-date	2018-11-10
pubs.volume	00

Abstract:

© 2018 IEEE. A simulation study was conducted to estimate the scatter fraction (SF) and to determine the most suitable line source radial offset displacement required to measure the SF for the total body long axial field-of-view (LAFOV) PET scanner by simulating different cylindrical and anthropomorphic digital phantoms. Simulations are conducted using a scanner model together with scatter phantoms adapted from the NEMA NU-2 2007 scatter phantom design, modified to suit the dimensions of the respective scanners, with line sources of various activities placed at a 45 mm radial offset. SF estimates obtained using the NEMA protocol are compared to values obtained with uniformly filled water phantom of the same length. A whole-body study is conducted using a set of 12 anthropomorphic phantoms with different BMIs, with different organs and anatomical structures filled with realistic concentrations of 18F-FDG. The SF obtained at 45 mm radial offset using 1 kBq/ml with the 200 cm (LAFOV scanner) and 70 cm (mCT) cylindrical phantoms are 40.07% and 34.35%, respectively. In both cases, a comparison with the SF estimate obtained with a uniformly filled cylindrical phantom shows that the NEMA NU2-2007 phantom with the line source positioned at the recommended radial offset of 45 mm significantly overestimates the SF. Instead, it was found that for both scanners, the optimal radial offset for accurate estimation of the SF was approximately 60 mm. High SF correlation coefficients were obtained between the SFs estimated with anthropomorphic phantoms with realistic biodistribution of 18F-FDG and an equivalent volume cylindrical phantom for the LAFOV PET scanner; in addition, BMI was strongly positively correlated with SF. The SF is found to be higher for the LAFOV compared with the mCT PET scanner. The optimal radial displacement for a LAFOV PET scanner using a NEMA-like phantom was found to be 60 mm, compared to the value of 45 mm suggested by the NEMA protocol.

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http://hdl.handle.net/10453/147539