Biophysical nanotools for single-molecule dynamics.

Su, QP; Ju, LA

Biophysical nanotools for single-molecule dynamics.

Su, QP Ju, LA

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Biophysical reviews, 2018, 10, (5), pp. 1349-1357
Issue Date:: 2018-10

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Field	Value	Language
dc.contributor.author	Su, QP
dc.contributor.author	Ju, LA
dc.date.accessioned	2021-04-26T04:11:35Z
dc.date.available	2018-08-06
dc.date.available	2021-04-26T04:11:35Z
dc.date.issued	2018-10
dc.identifier.citation	Biophysical reviews, 2018, 10, (5), pp. 1349-1357
dc.identifier.issn	1867-2450
dc.identifier.issn	1867-2469
dc.identifier.uri	http://hdl.handle.net/10453/148366
dc.description.abstract	The focus of the cell biology field is now shifting from characterizing cellular activities to organelle and molecular behaviors. This process accompanies the development of new biophysical visualization techniques that offer high spatial and temporal resolutions with ultra-sensitivity and low cell toxicity. They allow the biology research community to observe dynamic behaviors from scales of single molecules, organelles, cells to organoids, and even live animal tissues. In this review, we summarize these biophysical techniques into two major classes: the mechanical nanotools like dynamic force spectroscopy (DFS) and the optical nanotools like single-molecule and super-resolution microscopy. We also discuss their applications in elucidating molecular dynamics and functionally mapping of interactions between inter-cellular networks and intra-cellular components, which is key to understanding cellular processes such as adhesion, trafficking, inheritance, and division.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Biophysical reviews
dc.relation.isbasedon	10.1007/s12551-018-0447-y
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0299 Other Physical Sciences, 0601 Biochemistry and Cell Biology, 1116 Medical Physiology
dc.title	Biophysical nanotools for single-molecule dynamics.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	Germany
utslib.for	029901 Biological Physics
utslib.for	0299 Other Physical Sciences
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2021-04-26T04:11:34Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	10
utslib.citation.issue	5

Abstract:

The focus of the cell biology field is now shifting from characterizing cellular activities to organelle and molecular behaviors. This process accompanies the development of new biophysical visualization techniques that offer high spatial and temporal resolutions with ultra-sensitivity and low cell toxicity. They allow the biology research community to observe dynamic behaviors from scales of single molecules, organelles, cells to organoids, and even live animal tissues. In this review, we summarize these biophysical techniques into two major classes: the mechanical nanotools like dynamic force spectroscopy (DFS) and the optical nanotools like single-molecule and super-resolution microscopy. We also discuss their applications in elucidating molecular dynamics and functionally mapping of interactions between inter-cellular networks and intra-cellular components, which is key to understanding cellular processes such as adhesion, trafficking, inheritance, and division.

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http://hdl.handle.net/10453/148366