The impact of pharmacist/physician care on quality of life in elderly heart failure patients: results of the PHARM-CHF randomized controlled trial.

Schulz, M; Griese-Mammen, N; Schumacher, PM; Anker, SD; Koehler, F; Ruckes, C; Rettig-Ewen, V; Wachter, R; Trenk, D; Böhm, M; Laufs, U

The impact of pharmacist/physician care on quality of life in elderly heart failure patients: results of the PHARM-CHF randomized controlled trial.

Schulz, M

Griese-Mammen, N Schumacher, PM Anker, SD Koehler, F Ruckes, C Rettig-Ewen, V Wachter, R Trenk, D Böhm, M Laufs, U

Permalink

Publisher:: Wiley Open Access
Publication Type:: Journal Article
Citation:: ESC Heart Failure, 2020, 7, (6), pp. 3310-3319
Issue Date:: 2020-07-23

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (1.09 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Schulz, M https://orcid.org/0000-0002-5876-7322
dc.contributor.author	Griese-Mammen, N
dc.contributor.author	Schumacher, PM
dc.contributor.author	Anker, SD
dc.contributor.author	Koehler, F
dc.contributor.author	Ruckes, C
dc.contributor.author	Rettig-Ewen, V
dc.contributor.author	Wachter, R
dc.contributor.author	Trenk, D
dc.contributor.author	Böhm, M
dc.contributor.author	Laufs, U
dc.date.accessioned	2021-05-04T23:20:59Z
dc.date.available	2020-07-13
dc.date.available	2021-05-04T23:20:59Z
dc.date.issued	2020-07-23
dc.identifier.citation	ESC Heart Failure, 2020, 7, (6), pp. 3310-3319
dc.identifier.issn	2055-5822
dc.identifier.issn	2055-5822
dc.identifier.uri	http://hdl.handle.net/10453/148620
dc.description.abstract	<h4>Aims</h4>Patients with heart failure (HF) have impaired quality of life (QoL). The randomized controlled trial PHARM-CHF investigated whether an interdisciplinary intervention consisting of regular contacts with the community pharmacy and weekly dosing aids improves medication adherence in patients with HF. It is unknown how an intervention involving frequent structured pharmacy visits affects QoL. Our aim was to explore adherence to the intervention and effects on QoL.<h4>Methods and results</h4>Among 237 patients, n = 110 were randomized to pharmacy care and n = 127 to usual care. The pharmacy care group received a medication review followed by (bi-)weekly dose dispensing and counselling. The median follow-up was 2.0 years [inter-quartile range (IQR) 1.2-2.7]. Median interval between pharmacy visits was 8.4 days (IQR 8.0-10.3) and the visits lasted in median 14 min (IQR 10-15). Median adherence to the intervention was 96% (IQR 84-100). QoL at 365 days was predefined as a main secondary and at 730 days as another secondary endpoint in PHARM-CHF. QoL was measured by the Minnesota Living with Heart Failure Questionnaire; and for 111 patients (n = 47 in the pharmacy care group and n = 64 in the usual care group), data were available at baseline, and after 365 and 730 days (mean age 74 years; 41% female). Improvement in QoL was numerically higher in the pharmacy care group after 365 days and was significantly better after 730 days (difference in total scores -7.7 points [-14.5 to -1.0]; P = 0.026) compared to the usual care group. In all subgroups examined, this treatment effect was preserved. Improvements in the physical and emotional dimensions were numerically higher in the pharmacy care group after 365 days and were significantly better after 730 days: -4.0 points [-6.9 to -1.2]; P = 0.006, and -1.9 points [-3.7 to -0.1]; P = 0.039, respectively.<h4>Conclusions</h4>A pharmacy-based interdisciplinary intervention was well received by the patients and suggests clinically important improvements in QoL.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley Open Access
dc.relation.ispartof	ESC Heart Failure
dc.relation.isbasedon	10.1002/ehf2.12904
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology
dc.title	The impact of pharmacist/physician care on quality of life in elderly heart failure patients: results of the PHARM-CHF randomized controlled trial.
dc.type	Journal Article
utslib.citation.volume	7
utslib.location.activity	England
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1102 Cardiorespiratory Medicine and Haematology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	true
dc.date.updated	2021-05-04T23:20:55Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	7
utslib.citation.issue	6

Abstract:

Aims

Patients with heart failure (HF) have impaired quality of life (QoL). The randomized controlled trial PHARM-CHF investigated whether an interdisciplinary intervention consisting of regular contacts with the community pharmacy and weekly dosing aids improves medication adherence in patients with HF. It is unknown how an intervention involving frequent structured pharmacy visits affects QoL. Our aim was to explore adherence to the intervention and effects on QoL.

Methods and results

Among 237 patients, n = 110 were randomized to pharmacy care and n = 127 to usual care. The pharmacy care group received a medication review followed by (bi-)weekly dose dispensing and counselling. The median follow-up was 2.0 years [inter-quartile range (IQR) 1.2-2.7]. Median interval between pharmacy visits was 8.4 days (IQR 8.0-10.3) and the visits lasted in median 14 min (IQR 10-15). Median adherence to the intervention was 96% (IQR 84-100). QoL at 365 days was predefined as a main secondary and at 730 days as another secondary endpoint in PHARM-CHF. QoL was measured by the Minnesota Living with Heart Failure Questionnaire; and for 111 patients (n = 47 in the pharmacy care group and n = 64 in the usual care group), data were available at baseline, and after 365 and 730 days (mean age 74 years; 41% female). Improvement in QoL was numerically higher in the pharmacy care group after 365 days and was significantly better after 730 days (difference in total scores -7.7 points [-14.5 to -1.0]; P = 0.026) compared to the usual care group. In all subgroups examined, this treatment effect was preserved. Improvements in the physical and emotional dimensions were numerically higher in the pharmacy care group after 365 days and were significantly better after 730 days: -4.0 points [-6.9 to -1.2]; P = 0.006, and -1.9 points [-3.7 to -0.1]; P = 0.039, respectively.

Conclusions

A pharmacy-based interdisciplinary intervention was well received by the patients and suggests clinically important improvements in QoL.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/148620