Prediction of the treatment response in ovarian cancer: a ctDNA approach.

Sharbatoghli, M; Vafaei, S; Aboulkheyr Es, H; Asadi-Lari, M; Totonchi, M; Madjd, Z

Prediction of the treatment response in ovarian cancer: a ctDNA approach.

Sharbatoghli, M Vafaei, S Aboulkheyr Es, H Asadi-Lari, M Totonchi, M Madjd, Z

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Journal of ovarian research, 2020, 13, (1), pp. 124
Issue Date:: 2020-10-19

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Field	Value	Language
dc.contributor.author	Sharbatoghli, M
dc.contributor.author	Vafaei, S
dc.contributor.author	Aboulkheyr Es, H
dc.contributor.author	Asadi-Lari, M
dc.contributor.author	Totonchi, M
dc.contributor.author	Madjd, Z
dc.date.accessioned	2021-05-21T05:31:53Z
dc.date.available	2020-10-11
dc.date.available	2021-05-21T05:31:53Z
dc.date.issued	2020-10-19
dc.identifier.citation	Journal of ovarian research, 2020, 13, (1), pp. 124
dc.identifier.issn	1757-2215
dc.identifier.issn	1757-2215
dc.identifier.uri	http://hdl.handle.net/10453/149047
dc.description.abstract	Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular markers toward prediction of treatment response. Recently, analysis of liquid biopsies including circulating tumor DNA (ctDNA) open new way toward cancer diagnosis and treatment in a personalized manner in various types of solid tumors. In the case of ovarian carcinoma, growing pre-clinical and clinical studies underscored promising application of ctDNA in diagnosis, prognosis, and prediction of treatment response. In this review, we accumulate and highlight recent molecular findings of ctDNA analysis and its associations with treatment response and patient outcome. Additionally, we discussed the potential application of ctDNA in the personalized treatment of ovarian carcinoma. ctDNA-monitoring usage during the ovarian cancer treatments procedures.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Journal of ovarian research
dc.relation.isbasedon	10.1186/s13048-020-00729-1
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Prediction of the treatment response in ovarian cancer: a ctDNA approach.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-05-21T05:31:50Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	1

Abstract:

Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular markers toward prediction of treatment response. Recently, analysis of liquid biopsies including circulating tumor DNA (ctDNA) open new way toward cancer diagnosis and treatment in a personalized manner in various types of solid tumors. In the case of ovarian carcinoma, growing pre-clinical and clinical studies underscored promising application of ctDNA in diagnosis, prognosis, and prediction of treatment response. In this review, we accumulate and highlight recent molecular findings of ctDNA analysis and its associations with treatment response and patient outcome. Additionally, we discussed the potential application of ctDNA in the personalized treatment of ovarian carcinoma. ctDNA-monitoring usage during the ovarian cancer treatments procedures.

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http://hdl.handle.net/10453/149047