A systematic literature review assessing if genetic biomarkers are predictors for platinum-based chemotherapy response in ovarian cancer patients.

Phillips-Chavez, C; Watson, M; Coward, J; Schloss, J

A systematic literature review assessing if genetic biomarkers are predictors for platinum-based chemotherapy response in ovarian cancer patients.

Phillips-Chavez, C Watson, M Coward, J Schloss, J

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Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: European journal of clinical pharmacology, 2020, 76, (8), pp. 1059-1074
Issue Date:: 2020-08

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Field	Value	Language
dc.contributor.author	Phillips-Chavez, C
dc.contributor.author	Watson, M
dc.contributor.author	Coward, J
dc.contributor.author	Schloss, J https://orcid.org/0000-0003-1643-6215
dc.date.accessioned	2021-05-21T21:55:53Z
dc.date.available	2020-04-06
dc.date.available	2021-05-21T21:55:53Z
dc.date.issued	2020-08
dc.identifier.citation	European journal of clinical pharmacology, 2020, 76, (8), pp. 1059-1074
dc.identifier.issn	0031-6970
dc.identifier.issn	1432-1041
dc.identifier.uri	http://hdl.handle.net/10453/149053
dc.description.abstract	<h4>Background</h4>Ovarian cancer is the deadliest of gynecologic malignancies with the 5-year overall survival rate remaining at approximately 30%, a rate that has not improved over the last three decades. Standard of care for epithelial ovarian cancer patients consists of a platinum compound with a taxane given intravenously following debulking surgery; however, 80% of cases relapse within 2 years of diagnosis. This review sought to identify key underlying biomarkers related to platinum resistance in ovarian cancer to establish possible prognostic biomarkers of chemoresponse.<h4>Methods</h4>A systematic literature review was conducted across three databases PubMed, EMBASE and SCOPUS to summarise the evidence for prognostic biomarkers in platinum-resistant ovarian cancer patients.<h4>Results</h4>Forty-eight human studies were used in the review encompassing 6719 participants in retrospective and prospective study designs. A total of 68 biomarkers were reported that were significantly correlated with chemoresponse and/or survival reporting a p value less than or equal to 0.05.<h4>Conclusion</h4>This review accentuates the pleiotropic phenotypic complexities related to the response to platinum therapy in ovarian cancer. A one-size-fits-all approach may be ineffective in a large portion of patients, emphasising the need for a whole system-based approach and personalised treatment strategies. Identifying key biomarkers to aid clinical decision-making is the first essential step in developing and appropriating therapies for at-risk patients, reducing toxicity and improving quality of life.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	European journal of clinical pharmacology
dc.relation.isbasedon	10.1007/s00228-020-02874-4
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.mesh	Humans
dc.subject.mesh	Ovarian Neoplasms
dc.subject.mesh	Platinum Compounds
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Drug Resistance, Neoplasm
dc.subject.mesh	Female
dc.subject.mesh	Biomarkers
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Biomarkers
dc.subject.mesh	Drug Resistance, Neoplasm
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Ovarian Neoplasms
dc.subject.mesh	Platinum Compounds
dc.subject.mesh	Treatment Outcome
dc.title	A systematic literature review assessing if genetic biomarkers are predictors for platinum-based chemotherapy response in ovarian cancer patients.
dc.type	Journal Article
utslib.citation.volume	76
utslib.location.activity	Germany
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2021-05-21T21:55:52Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	76
utslib.citation.issue	8

Abstract:

Background

Ovarian cancer is the deadliest of gynecologic malignancies with the 5-year overall survival rate remaining at approximately 30%, a rate that has not improved over the last three decades. Standard of care for epithelial ovarian cancer patients consists of a platinum compound with a taxane given intravenously following debulking surgery; however, 80% of cases relapse within 2 years of diagnosis. This review sought to identify key underlying biomarkers related to platinum resistance in ovarian cancer to establish possible prognostic biomarkers of chemoresponse.

Methods

A systematic literature review was conducted across three databases PubMed, EMBASE and SCOPUS to summarise the evidence for prognostic biomarkers in platinum-resistant ovarian cancer patients.

Results

Forty-eight human studies were used in the review encompassing 6719 participants in retrospective and prospective study designs. A total of 68 biomarkers were reported that were significantly correlated with chemoresponse and/or survival reporting a p value less than or equal to 0.05.

Conclusion

This review accentuates the pleiotropic phenotypic complexities related to the response to platinum therapy in ovarian cancer. A one-size-fits-all approach may be ineffective in a large portion of patients, emphasising the need for a whole system-based approach and personalised treatment strategies. Identifying key biomarkers to aid clinical decision-making is the first essential step in developing and appropriating therapies for at-risk patients, reducing toxicity and improving quality of life.

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http://hdl.handle.net/10453/149053