EXPRESS: International Stroke Genetics Consortium Recommendations for Studies of Genetics of Stroke Outcome and Recovery.

Lindgren, A; Braun, R; Majersik, JJ; Clatworthy, P; Mainali, S; Derdeyn, CP; Maguire, JM; Jern, C; Rosand, J; Cole, JW; Lee, J-M; Khatri, P; Nyquist, PA; Debette, SP; Keat Wei, L; Rundek, T; Leifer, D; Thijs, V; Lemmens, R; Heitsch, L; Prasad, K; Jimenez-Conde, J; Dichgans, M; Rost, NS; Cramer, SC; Bernhardt, J; Worrall, BB; Cadenas, I

EXPRESS: International Stroke Genetics Consortium Recommendations for Studies of Genetics of Stroke Outcome and Recovery.

Lindgren, A Braun, R Majersik, JJ Clatworthy, P Mainali, S Derdeyn, CP Maguire, JM Jern, C Rosand, J Cole, JW Lee, J-M Khatri, P Nyquist, PA Debette, SP Keat Wei, L Rundek, T Leifer, D Thijs, V Lemmens, R Heitsch, L Prasad, K Jimenez-Conde, J Dichgans, M Rost, NS Cramer, SC Bernhardt, J Worrall, BB Cadenas, I

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Publisher:: SAGE Publications
Publication Type:: Journal Article
Citation:: International Journal of Stroke, 2021, pp. 17474930211007288
Issue Date:: 2021-03-19

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Field	Value	Language
dc.contributor.author	Lindgren, A
dc.contributor.author	Braun, R
dc.contributor.author	Majersik, JJ
dc.contributor.author	Clatworthy, P
dc.contributor.author	Mainali, S
dc.contributor.author	Derdeyn, CP
dc.contributor.author	Maguire, JM
dc.contributor.author	Jern, C
dc.contributor.author	Rosand, J
dc.contributor.author	Cole, JW
dc.contributor.author	Lee, J-M
dc.contributor.author	Khatri, P
dc.contributor.author	Nyquist, PA
dc.contributor.author	Debette, SP
dc.contributor.author	Keat Wei, L
dc.contributor.author	Rundek, T
dc.contributor.author	Leifer, D
dc.contributor.author	Thijs, V
dc.contributor.author	Lemmens, R
dc.contributor.author	Heitsch, L
dc.contributor.author	Prasad, K
dc.contributor.author	Jimenez-Conde, J
dc.contributor.author	Dichgans, M
dc.contributor.author	Rost, NS
dc.contributor.author	Cramer, SC
dc.contributor.author	Bernhardt, J
dc.contributor.author	Worrall, BB
dc.contributor.author	Cadenas, I
dc.date.accessioned	2021-06-10T07:17:57Z
dc.date.available	2021-06-10T07:17:57Z
dc.date.issued	2021-03-19
dc.identifier.citation	International Journal of Stroke, 2021, pp. 17474930211007288
dc.identifier.issn	1747-4930
dc.identifier.issn	1747-4949
dc.identifier.uri	http://hdl.handle.net/10453/149494
dc.description.abstract	Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SAGE Publications
dc.relation.ispartof	International Journal of Stroke
dc.relation.isbasedon	10.1177/17474930211007288
dc.rights	Lindgren, Arne; Braun, Robynne; Majersik, Jennifer J.; Clatworthy, Philip; Mainali, Shraddha; Derdeyn, Colin P.; Maguire, Jane Margaret; Jern, Christina; Rosand, Jonathan; Cole, John W., et al. \| EXPRESS: International Stroke Genetics Consortium Recommendations for Studies of Genetics of Stroke Outcome and Recovery. \| International Journal of Stroke (Copyright © [2021]. DOI: https://journals.sagepub.com/doi/pdf/10.1177/17474930211007288
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	Neurology & Neurosurgery
dc.title	EXPRESS: International Stroke Genetics Consortium Recommendations for Studies of Genetics of Stroke Outcome and Recovery.
dc.type	Journal Article
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2021-06-10T07:17:56Z
pubs.publication-status	Published

Abstract:

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.

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http://hdl.handle.net/10453/149494