X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

Gu, X; Shen, C; Li, H; Goldys, EM; Deng, W

X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

Gu, X Shen, C Li, H Goldys, EM Deng, W

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Publisher:: BMC
Publication Type:: Journal Article
Citation:: Journal of nanobiotechnology, 2020, 18, (1), pp. 87
Issue Date:: 2020-06-10

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Field	Value	Language
dc.contributor.author	Gu, X
dc.contributor.author	Shen, C
dc.contributor.author	Li, H
dc.contributor.author	Goldys, EM
dc.contributor.author	Deng, W https://orcid.org/0000-0002-9413-0978
dc.date.accessioned	2021-07-04T23:56:02Z
dc.date.available	2020-06-01
dc.date.available	2021-07-04T23:56:02Z
dc.date.issued	2020-06-10
dc.identifier.citation	Journal of nanobiotechnology, 2020, 18, (1), pp. 87
dc.identifier.issn	1477-3155
dc.identifier.issn	1477-3155
dc.identifier.uri	http://hdl.handle.net/10453/149818
dc.description.abstract	In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.
dc.format	Electronic
dc.language	eng
dc.publisher	BMC
dc.relation	http://purl.org/au-research/grants/nhmrc/1181889
dc.relation.ispartof	Journal of nanobiotechnology
dc.relation.isbasedon	10.1186/s12951-020-00644-z
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	10 Technology
dc.subject.classification	Nanoscience & Nanotechnology
dc.subject.mesh	HCT116 Cells
dc.subject.mesh	Mitochondria
dc.subject.mesh	Humans
dc.subject.mesh	Gold
dc.subject.mesh	Singlet Oxygen
dc.subject.mesh	Liposomes
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	Apoptosis
dc.subject.mesh	X-Rays
dc.subject.mesh	Membrane Potential, Mitochondrial
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Apoptosis
dc.subject.mesh	Gold
dc.subject.mesh	HCT116 Cells
dc.subject.mesh	Humans
dc.subject.mesh	Liposomes
dc.subject.mesh	Membrane Potential, Mitochondrial
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Mitochondria
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	Singlet Oxygen
dc.subject.mesh	X-Rays
dc.title	X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	England
utslib.for	0903 Biomedical Engineering
utslib.for	10 Technology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-07-04T23:55:59Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	18
utslib.citation.issue	1

Abstract:

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

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http://hdl.handle.net/10453/149818