Advanced prostate cancer experimental radioactive treatment-clinical trial decision making: patient experiences.

Viljoen, B; Hofman, MS; Chambers, SK; Dunn, J; Dhillon, H; Davis, ID; Ralph, N

Advanced prostate cancer experimental radioactive treatment-clinical trial decision making: patient experiences.

Viljoen, B Hofman, MS Chambers, SK Dunn, J Dhillon, H Davis, ID Ralph, N

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Publisher:: BMJ
Publication Type:: Journal Article
Citation:: BMJ supportive & palliative care, 2021, pp. bmjspcare-2021-002994
Issue Date:: 2021-08-09

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Field	Value	Language
dc.contributor.author	Viljoen, B
dc.contributor.author	Hofman, MS
dc.contributor.author	Chambers, SK
dc.contributor.author	Dunn, J
dc.contributor.author	Dhillon, H
dc.contributor.author	Davis, ID
dc.contributor.author	Ralph, N
dc.date.accessioned	2021-09-06T23:46:24Z
dc.date.available	2021-07-08
dc.date.available	2021-09-06T23:46:24Z
dc.date.issued	2021-08-09
dc.identifier.citation	BMJ supportive & palliative care, 2021, pp. bmjspcare-2021-002994
dc.identifier.issn	2045-435X
dc.identifier.issn	2045-4368
dc.identifier.uri	http://hdl.handle.net/10453/150371
dc.description.abstract	<h4>Objectives</h4>Nested qualitative studies within clinical trials provide the opportunity to better understand participant experiences of participation and identify areas where improved support is required. The purpose of this qualitative study is to describe the lived experiences of men with advanced prostate cancer participating in the TheraP trial; a randomised trial of <sup>177</sup>Lu-PSMA-617 compared with cabazitaxel chemotherapy.<h4>Methods</h4>Fifteen men with advanced prostate cancer were recruited from the TheraP clinical trial and interviewed at three time points during the trial. Interviews were inductively analysed using thematic analysis. This research paper reports the results from the baseline interview at commencement of the trial, focusing specifically on participants' enrolment experiences.<h4>Results</h4>Four themes were identified representing the lived experiences of men with advanced prostate cancer deciding to participate in the TheraP trial: (1) hoping to survive; (2) needing to feel informed; (3) choosing to participate and (4) being randomised. The process of deciding to enrol in a clinical trial is filled with indecision, emotional difficulties and focused on a desire to live.<h4>Conclusions</h4>For men with advanced prostate cancer, the experience of deciding to enrol in a clinical trial is principally driven by a desire to survive but interlinked with the need to make an informed decision as participants in this study expressed a preference for allocation to the experimental arm. Men seeking to enrol in clinical trials of new prostate cancer treatments would benefit from improved informational and decision support.<h4>Trial registration number</h4>NCT03392428, ANZUP1603.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	BMJ
dc.relation.ispartof	BMJ supportive & palliative care
dc.relation.isbasedon	10.1136/bmjspcare-2021-002994
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights	© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
dc.subject	1110 Nursing, 1117 Public Health and Health Services
dc.title	Advanced prostate cancer experimental radioactive treatment-clinical trial decision making: patient experiences.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1110 Nursing
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	recently_added	*
dc.date.updated	2021-09-06T23:46:23Z
pubs.publication-status	Published

Abstract:

Objectives

Nested qualitative studies within clinical trials provide the opportunity to better understand participant experiences of participation and identify areas where improved support is required. The purpose of this qualitative study is to describe the lived experiences of men with advanced prostate cancer participating in the TheraP trial; a randomised trial of ¹⁷⁷Lu-PSMA-617 compared with cabazitaxel chemotherapy.

Methods

Fifteen men with advanced prostate cancer were recruited from the TheraP clinical trial and interviewed at three time points during the trial. Interviews were inductively analysed using thematic analysis. This research paper reports the results from the baseline interview at commencement of the trial, focusing specifically on participants' enrolment experiences.

Results

Four themes were identified representing the lived experiences of men with advanced prostate cancer deciding to participate in the TheraP trial: (1) hoping to survive; (2) needing to feel informed; (3) choosing to participate and (4) being randomised. The process of deciding to enrol in a clinical trial is filled with indecision, emotional difficulties and focused on a desire to live.

Conclusions

For men with advanced prostate cancer, the experience of deciding to enrol in a clinical trial is principally driven by a desire to survive but interlinked with the need to make an informed decision as participants in this study expressed a preference for allocation to the experimental arm. Men seeking to enrol in clinical trials of new prostate cancer treatments would benefit from improved informational and decision support.

Trial registration number

NCT03392428, ANZUP1603.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/150371