Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung

Islam, MS; Larpruenrudee, P; Hossain, SI; Rahimi-Gorji, M; Gu, Y; Saha, SC; Paul, G

Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung

Islam, MS Larpruenrudee, P Hossain, SI Rahimi-Gorji, M Gu, Y Saha, SC Paul, G

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: International Journal of Environmental Research and Public Health, 2021, 18, (12)
Issue Date:: 2021-06-09

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Field	Value	Language
dc.contributor.author	Islam, MS
dc.contributor.author	Larpruenrudee, P
dc.contributor.author	Hossain, SI
dc.contributor.author	Rahimi-Gorji, M
dc.contributor.author	Gu, Y
dc.contributor.author	Saha, SC
dc.contributor.author	Paul, G
dc.date.accessioned	2021-09-08T09:59:45Z
dc.date.available	2021-06-07
dc.date.available	2021-09-08T09:59:45Z
dc.date.issued	2021-06-09
dc.identifier.citation	International Journal of Environmental Research and Public Health, 2021, 18, (12)
dc.identifier.issn	1661-7827
dc.identifier.issn	1660-4601
dc.identifier.uri	http://hdl.handle.net/10453/150403
dc.description.abstract	A comprehensive understanding of airflow characteristics and particle transport in the human lung can be useful in modelling to inform clinical diagnosis, treatment, and management, including prescription medication and risk assessment for rehabilitation. One of the difficulties in clinical treatment of lung disorders lies in the patients' variable physical lung characteristics caused by age, amongst other factors, such as different lung sizes. A precise understanding of the comparison between different age groups with various flow rates is missing in the literature, and this study aims to analyse the airflow and aerosol transport within the age-specific lung. ANSYS Fluent solver and the large-eddy simulation (LES) model were employed for the numerical simulation. The numerical model was validated with the available literature and the computational results showed airway size-reduction significantly affected airflow and particle transport in the upper airways. This study reports higher deposition at the mouth-throat region for larger diameter particles. The overall deposition efficiency (DE) increased with airway size reduction and flow rate. Lung aging effected the pressure distribution and a higher pressure drop was reported for the aged lung as compared to the younger lung. These findings could inform medical management through individualised simulation of drug-aerosol delivery processes for the patient-specific lung.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	International Journal of Environmental Research and Public Health
dc.relation.isbasedon	10.3390/ijerph18126239
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology
dc.subject.mesh	Lung
dc.subject.mesh	Humans
dc.subject.mesh	Aerosols
dc.subject.mesh	Administration, Inhalation
dc.subject.mesh	Age Factors
dc.subject.mesh	Particle Size
dc.subject.mesh	Models, Biological
dc.subject.mesh	Computer Simulation
dc.subject.mesh	Aged
dc.subject.mesh	Administration, Inhalation
dc.subject.mesh	Aerosols
dc.subject.mesh	Age Factors
dc.subject.mesh	Aged
dc.subject.mesh	Computer Simulation
dc.subject.mesh	Humans
dc.subject.mesh	Lung
dc.subject.mesh	Models, Biological
dc.subject.mesh	Particle Size
dc.title	Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-09-08T09:59:39Z
pubs.issue	12
pubs.publication-status	Published
pubs.volume	18
utslib.citation.issue	12

Abstract:

A comprehensive understanding of airflow characteristics and particle transport in the human lung can be useful in modelling to inform clinical diagnosis, treatment, and management, including prescription medication and risk assessment for rehabilitation. One of the difficulties in clinical treatment of lung disorders lies in the patients' variable physical lung characteristics caused by age, amongst other factors, such as different lung sizes. A precise understanding of the comparison between different age groups with various flow rates is missing in the literature, and this study aims to analyse the airflow and aerosol transport within the age-specific lung. ANSYS Fluent solver and the large-eddy simulation (LES) model were employed for the numerical simulation. The numerical model was validated with the available literature and the computational results showed airway size-reduction significantly affected airflow and particle transport in the upper airways. This study reports higher deposition at the mouth-throat region for larger diameter particles. The overall deposition efficiency (DE) increased with airway size reduction and flow rate. Lung aging effected the pressure distribution and a higher pressure drop was reported for the aged lung as compared to the younger lung. These findings could inform medical management through individualised simulation of drug-aerosol delivery processes for the patient-specific lung.

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http://hdl.handle.net/10453/150403