Adverse pregnancy and neonatal outcomes associated with <i>Neisseria gonorrhoeae:</i> systematic review and meta-analysis.
Vallely, LM
Egli-Gany, D
Wand, H
Pomat, WS
Homer, CSE
Guy, R
Silver, B
Rumbold, AR
Kaldor, JM
Vallely, AJ
Low, N
Low, N
- Publisher:
- BMJ
- Publication Type:
- Journal Article
- Citation:
- Sexually transmitted infections, 2021, 97, (2), pp. 104-111
- Issue Date:
- 2021-03
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Vallely, LM | |
dc.contributor.author | Egli-Gany, D | |
dc.contributor.author | Wand, H | |
dc.contributor.author | Pomat, WS | |
dc.contributor.author | Homer, CSE | |
dc.contributor.author | Guy, R | |
dc.contributor.author | Silver, B | |
dc.contributor.author | Rumbold, AR | |
dc.contributor.author | Kaldor, JM | |
dc.contributor.author | Vallely, AJ | |
dc.contributor.author | Low, N | |
dc.contributor.author | Low, N | |
dc.date.accessioned | 2021-09-08T21:58:14Z | |
dc.date.available | 2020-11-28 | |
dc.date.available | 2021-09-08T21:58:14Z | |
dc.date.issued | 2021-03 | |
dc.identifier.citation | Sexually transmitted infections, 2021, 97, (2), pp. 104-111 | |
dc.identifier.issn | 1368-4973 | |
dc.identifier.issn | 1472-3263 | |
dc.identifier.uri | http://hdl.handle.net/10453/150404 | |
dc.description.abstract | <h4>Objective</h4>To examine associations between <i>Neisseria gonorrhoeae</i> (NG) infection during pregnancy and the risk of preterm birth, spontaneous abortion, premature rupture of membranes, perinatal mortality, low birth weight and ophthalmia neonatorum.<h4>Data sources</h4>We searched Medline, EMBASE, the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature for studies published between 1948 and 14 January 2020.<h4>Methods</h4>Studies were included if they reported testing for NG during pregnancy and compared pregnancy, perinatal and/or neonatal outcomes between women with and without NG. Two reviewers independently assessed papers for inclusion and extracted data. Risk of bias was assessed using established checklists for each study design. Summary ORs with 95% CIs were generated using random effects models for both crude and, where available, adjusted associations.<h4>Results</h4>We identified 2593 records and included 30 in meta-analyses. Women with NG were more likely to experience preterm birth (OR 1.55, 95% CI 1.21 to 1.99, n=18 studies); premature rupture of membranes (OR 1.41, 95% CI 1.02 to 1.92, n=9); perinatal mortality (OR 2.16, 95% CI 1.35 to 3.46, n=9); low birth weight (OR 1.66, 95% CI 1.12 to 2.48, n=8) and ophthalmia neonatorum (OR 4.21, 95% CI 1.36 to 13.04, n=6). Summary adjusted ORs were, for preterm birth 1.90 (95% CI 1.14 to 3.19, n=5) and for low birth weight 1.48 (95% CI 0.79 to 2.77, n=4). In studies with a multivariable analysis, age was the variable most commonly adjusted for. NG was more strongly associated with preterm birth in low-income and middle-income countries (OR 2.21, 95% CI 1.40 to 3.48, n=7) than in high-income countries (OR 1.38, 95% CI 1.04 to 1.83, n=11).<h4>Conclusions</h4>NG is associated with a number of adverse pregnancy and newborn outcomes. Further research should be done to determine the role of NG in different perinatal mortality outcomes because interventions that reduce mortality will have the greatest impact on reducing the burden of disease in low-income and middle-income countries.<h4>Prospero registration number</h4>CRD42016050962. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | BMJ | |
dc.relation | Medical Research CouncilMR/N006089/1 | |
dc.relation.ispartof | Sexually transmitted infections | |
dc.relation.isbasedon | 10.1136/sextrans-2020-054653 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1103 Clinical Sciences, 1108 Medical Microbiology, 1117 Public Health and Health Services | |
dc.subject.classification | Public Health | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neisseria gonorrhoeae | |
dc.subject.mesh | Ophthalmia Neonatorum | |
dc.subject.mesh | Gonorrhea | |
dc.subject.mesh | Pregnancy Complications, Infectious | |
dc.subject.mesh | Abortion, Spontaneous | |
dc.subject.mesh | Fetal Membranes, Premature Rupture | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Infant, Newborn | |
dc.subject.mesh | Infant, Low Birth Weight | |
dc.subject.mesh | Female | |
dc.subject.mesh | Perinatal Mortality | |
dc.subject.mesh | Abortion, Spontaneous | |
dc.subject.mesh | Female | |
dc.subject.mesh | Fetal Membranes, Premature Rupture | |
dc.subject.mesh | Gonorrhea | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Infant, Low Birth Weight | |
dc.subject.mesh | Infant, Newborn | |
dc.subject.mesh | Neisseria gonorrhoeae | |
dc.subject.mesh | Ophthalmia Neonatorum | |
dc.subject.mesh | Perinatal Mortality | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Pregnancy Complications, Infectious | |
dc.title | Adverse pregnancy and neonatal outcomes associated with <i>Neisseria gonorrhoeae:</i> systematic review and meta-analysis. | |
dc.type | Journal Article | |
utslib.citation.volume | 97 | |
utslib.location.activity | England | |
utslib.for | 1103 Clinical Sciences | |
utslib.for | 1108 Medical Microbiology | |
utslib.for | 1117 Public Health and Health Services | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHSP - Health Services and Practice | |
pubs.organisational-group | /University of Technology Sydney/Strength - WHO CC | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2021-09-08T21:58:07Z | |
pubs.issue | 2 | |
pubs.publication-status | Published | |
pubs.volume | 97 | |
utslib.citation.issue | 2 |
Abstract:
Objective
To examine associations between Neisseria gonorrhoeae (NG) infection during pregnancy and the risk of preterm birth, spontaneous abortion, premature rupture of membranes, perinatal mortality, low birth weight and ophthalmia neonatorum.Data sources
We searched Medline, EMBASE, the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature for studies published between 1948 and 14 January 2020.Methods
Studies were included if they reported testing for NG during pregnancy and compared pregnancy, perinatal and/or neonatal outcomes between women with and without NG. Two reviewers independently assessed papers for inclusion and extracted data. Risk of bias was assessed using established checklists for each study design. Summary ORs with 95% CIs were generated using random effects models for both crude and, where available, adjusted associations.Results
We identified 2593 records and included 30 in meta-analyses. Women with NG were more likely to experience preterm birth (OR 1.55, 95% CI 1.21 to 1.99, n=18 studies); premature rupture of membranes (OR 1.41, 95% CI 1.02 to 1.92, n=9); perinatal mortality (OR 2.16, 95% CI 1.35 to 3.46, n=9); low birth weight (OR 1.66, 95% CI 1.12 to 2.48, n=8) and ophthalmia neonatorum (OR 4.21, 95% CI 1.36 to 13.04, n=6). Summary adjusted ORs were, for preterm birth 1.90 (95% CI 1.14 to 3.19, n=5) and for low birth weight 1.48 (95% CI 0.79 to 2.77, n=4). In studies with a multivariable analysis, age was the variable most commonly adjusted for. NG was more strongly associated with preterm birth in low-income and middle-income countries (OR 2.21, 95% CI 1.40 to 3.48, n=7) than in high-income countries (OR 1.38, 95% CI 1.04 to 1.83, n=11).Conclusions
NG is associated with a number of adverse pregnancy and newborn outcomes. Further research should be done to determine the role of NG in different perinatal mortality outcomes because interventions that reduce mortality will have the greatest impact on reducing the burden of disease in low-income and middle-income countries.Prospero registration number
CRD42016050962.Please use this identifier to cite or link to this item:
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