Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.

Lee, W; Pulbrook, M; Sheehan, C; Kochovska, S; Chang, S; Hosie, A; Lobb, E; Parker, D; Draper, B; Agar, MR; Currow, DC

Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.

Lee, W Pulbrook, M Sheehan, C Kochovska, S

Chang, S

Hosie, A

Lobb, E Parker, D

Draper, B Agar, MR Currow, DC

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Publisher:: ELSEVIER SCIENCE INC
Publication Type:: Journal Article
Citation:: Journal of pain and symptom management, 2021, 61, (1), pp. 143-166.e2
Issue Date:: 2021-01

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Field	Value	Language
dc.contributor.author	Lee, W
dc.contributor.author	Pulbrook, M
dc.contributor.author	Sheehan, C
dc.contributor.author	Kochovska, S https://orcid.org/0000-0002-3531-0389
dc.contributor.author	Chang, S https://orcid.org/0000-0003-0723-3192
dc.contributor.author	Hosie, A https://orcid.org/0000-0003-1674-2124
dc.contributor.author	Lobb, E
dc.contributor.author	Parker, D https://orcid.org/0000-0003-2552-8613
dc.contributor.author	Draper, B
dc.contributor.author	Agar, MR
dc.contributor.author	Currow, DC
dc.date.accessioned	2021-09-13T23:44:39Z
dc.date.available	2020-07-13
dc.date.available	2021-09-13T23:44:39Z
dc.date.issued	2021-01
dc.identifier.citation	Journal of pain and symptom management, 2021, 61, (1), pp. 143-166.e2
dc.identifier.issn	0885-3924
dc.identifier.issn	1873-6513
dc.identifier.uri	http://hdl.handle.net/10453/150519
dc.description.abstract	<h4>Context</h4>Currently, systematic evidence of the prevalence of clinically significant depressive symptoms in people with extremely short prognoses is not available to inform its global burden, assessment, and management.<h4>Objectives</h4>To determine the prevalence of clinically significant depressive symptoms in people with advanced life-limiting illnesses and extremely short prognoses (range of days to weeks).<h4>Methods</h4>A systematic review and meta-analysis (random-effects model) were performed (PROSPERO: CRD42019125119). MEDLINE, Embase, PsycINFO, CINAHL, and CareSearch were searched for studies (1994-2019). Data were screened for the prevalence of clinically significant depressive symptoms (assessed using validated depression-specific screening tools or diagnostic criteria) of adults with advanced life-limiting illnesses and extremely short prognoses (defined by survival or functional status). Quality assessment was performed using the Joanna Briggs Institute Systematic Reviews Checklist for Prevalence Studies for individual studies and Grading of Recommendations Assessment, Development and Evaluation (GRADE) across studies.<h4>Results</h4>Thirteen studies were included. The overall pooled prevalence of clinically significant depressive symptoms in adults with extremely short prognoses (n = 10 studies; extremely short prognoses: N = 905) using depression-specific screening tools was 50% (95% CI: 29%-70%; I<sup>2</sup> = 97.6%). Prevalence of major and minor depression was 10% (95% CI: 4%-16%) and 5% (95% CI: 2%-8%), respectively. Major limitations included high heterogeneity, selection bias, and small sample sizes in individual studies.<h4>Conclusions</h4>Clinically, significant depressive symptoms were prevalent in people with advanced life-limiting illnesses and extremely short prognoses. Clinicians need to be proactive in the recognition and assessment of these symptoms to allow for timely intervention.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE INC
dc.relation.ispartof	Journal of pain and symptom management
dc.relation.isbasedon	10.1016/j.jpainsymman.2020.07.011
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Anesthesiology
dc.subject.mesh	Humans
dc.subject.mesh	Prognosis
dc.subject.mesh	Prevalence
dc.subject.mesh	Depression
dc.subject.mesh	Quality of Life
dc.subject.mesh	Adult
dc.subject.mesh	Adult
dc.subject.mesh	Depression
dc.subject.mesh	Humans
dc.subject.mesh	Prevalence
dc.subject.mesh	Prognosis
dc.subject.mesh	Quality of Life
dc.title	Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.
dc.type	Journal Article
utslib.citation.volume	61
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-09-13T23:44:38Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	61
utslib.citation.issue	1

Abstract:

Context

Currently, systematic evidence of the prevalence of clinically significant depressive symptoms in people with extremely short prognoses is not available to inform its global burden, assessment, and management.

Objectives

To determine the prevalence of clinically significant depressive symptoms in people with advanced life-limiting illnesses and extremely short prognoses (range of days to weeks).

Methods

A systematic review and meta-analysis (random-effects model) were performed (PROSPERO: CRD42019125119). MEDLINE, Embase, PsycINFO, CINAHL, and CareSearch were searched for studies (1994-2019). Data were screened for the prevalence of clinically significant depressive symptoms (assessed using validated depression-specific screening tools or diagnostic criteria) of adults with advanced life-limiting illnesses and extremely short prognoses (defined by survival or functional status). Quality assessment was performed using the Joanna Briggs Institute Systematic Reviews Checklist for Prevalence Studies for individual studies and Grading of Recommendations Assessment, Development and Evaluation (GRADE) across studies.

Results

Thirteen studies were included. The overall pooled prevalence of clinically significant depressive symptoms in adults with extremely short prognoses (n = 10 studies; extremely short prognoses: N = 905) using depression-specific screening tools was 50% (95% CI: 29%-70%; I² = 97.6%). Prevalence of major and minor depression was 10% (95% CI: 4%-16%) and 5% (95% CI: 2%-8%), respectively. Major limitations included high heterogeneity, selection bias, and small sample sizes in individual studies.

Conclusions

Clinically, significant depressive symptoms were prevalent in people with advanced life-limiting illnesses and extremely short prognoses. Clinicians need to be proactive in the recognition and assessment of these symptoms to allow for timely intervention.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/150519