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Harnessing nanotechnology for enhanced delivery of erlotinib: a dynamic duo in cancer treatment

Pahwa, R Saini, S Chhabra, J Goyal, R Kumar, S Awasthi, R Dureja, H

Erlotinib is a reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that acts by inhibiting signaling pathways, resulting in the disruption of cancerous cell proliferation. ...

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Outcomes of SDHB Pathogenic Variant Carriers.

Davidoff, DF De Abreu Lourenco, R Tsang, VHM Benn, DE Clifton-Bligh, RJ

CONTEXT: Carriers of germline pathogenic variants (PVs) in succinate dehydrogenase type B (SDHB) are at increased risk of developing pheochromocytomas and paragangliomas (PPGLs). Understanding thei...

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A randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC).

Wigg, A Tibballs, J Woodman, R Stuart, K Le, H Roberts, SK Olynyk, JK Strasser, SI Wallace, M Martin, J Haworth, A Hardcastle, N Loo, KF Tang, C Lee, YY Chu, J De Abreu Lourenco, R Koukourou, A De Boo, D McLean, K Buck, J Sawhney, R Nicoll, A Dev, A Wood, M Braund, A Weltman, M Khor, R Levy, M Wang, T Potter, M Haridy, J Raj, A Duncan, O Zekry, A Collier, N O'Beirne, J Holliday, C Trada, Y Tronidjaja, J George, J Pryor, D

BACKGROUND: Therapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver dysfunction and comorbidities. Many patients with e...

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Global malaria vaccine research and community perception in Africa: a systematic review

Chutiyami, M Bello, UM Salihu, D

Abstract Background Malaria vaccine is one of the critical areas in tropic...

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Incidence of mother-to-child transmission of HIV and predictors of positivity among HIV exposed infants in South Gondar public hospitals, Northwest Ethiopia: competing risk regression model.

Tilaye, BA Hailemeskel, HS Baye, FD Hailu, MK Mekonnen, GB Arage, G Birhane, BM Tibebu, NS Moges, N

BACKGROUND: The principal route of HIV infection in children is vertical transmission. Thus, this study aimed to assess the incidence of mother-to-child transmission of HIV and predictors of positi...

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Implementing palliative care in hepatocellular carcinoma ambulatory clinics-study protocol for Accelerated translational research in PRImary liver CAncer (APRICA) randomised controlled palliative care trial.

Gofton, C Di Bartolomeo, A Boutros, R Zurynski, YA Stafford-Bell, F Caldwell, K McCaughan, G Zekry, A Strasser, SI Levy, M Sheehan, C Goodall, S Davis, JM Sheahan, L Liu, K Greenaway, S Davison, S Du Huynh, T Quadri, Z Agar, M George, J

BACKGROUND: Integration of symptom and palliative care for people with advanced cancer is established in many tumour types, but its role in people with hepatocellular carcinoma (HCC) has not been c...

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The Short Form 6 Dimensions (SF-6D): Development and Evolution.

Mukuria, C Rowen, D Mulhern, B McDool, E Kharroubi, S Bjorner, JB Brazier, JE

This paper considers the development and evolution of the short-form 6 dimensions (SF-6D), a generic preference-weighted measure consisting of a health classification with accompanying value set th...

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Feasibility and acceptability of the brief patient-reported experience measure consideRATE within the hospital setting for patients with palliative care needs, their families/carers and clinicians.

Virdun, C Button, E Phillips, JL Saunders, CH Yates, P Luckett, T

BACKGROUND: Supporting clinical teams to improve care for inpatients with palliative care needs and their carers is a known priority. Patient reported experience measures (PREMs) may assist in impr...

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Reducing teachers’ workload or deskilling ‘core’ work? Analysis of a policy response to teacher workload demands

Stacey, M Gavin, M Fitzgerald, S McGrath-Champ, S Wilson, R

Teacher workload is a growing problem internationally. In this article, we analyse an attempt by the state education bureaucracy of New South Wales (NSW), Australia, to address this through the ‘Qu...

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Intra-professional collaboration and organization of work among teachers: How entangled institutional logics shape connectivity

Parding, K Gavin, M Wilson, R Fitzgerald, S Jakobsson, M McGrath-Champ, S

Intra-professional collaboration is essential as it enables professionals to learn, develop, and define the terms of the profession in their own way. Yet conditions for collaboration are shaped by ...

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