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A pilot study of re-purposing drugs to treat koalas with chlamydia.

Fleming, C Nugent, H Quinteros, SL Fernando, BSM Tyndall, JDA Webb, JK Mella, VSA Huston, WM

The koala (Phascolarctos cinereus) is an endangered species in parts of Australia, in part due to chlamydial infections. Treatment is difficult due to the hepatic metabolism of the koala, and the c...

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Investigating the adoption of voluntary sustainability initiatives when mining for battery minerals: An iterative systems thinking approach.

Mendonca Severiano, B Northey, SA Hyman, J Giurco, D

Decarbonizing the automotive sector is leading to a significant shift towards electric vehicle (EV) adoption, underpinning the need for lithium-ion batteries, which in turn, depend on the extractio...

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Why aquatic deoxygenation belongs in the planetary boundary framework

Ferrer, EM Pezner, AK Eddebbar, YA Breitburg, D Crowe, S Garçon, V Grégoire, M Jane, SF Leavitt, PR Levin, L Rose, K Wallace, D

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Cold-stored platelets: revisiting assumptions and addressing variability to support implementation.

Mahajan, J Padula, MP Marks, DC Johnson, L

Platelets are transfused to patients to prevent and stop bleeding. Conventionally, platelets are stored at room temperature (RT; 20-24 °C), however, this limits their shelf life to 5-7 days, due to...

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Intersecting SARS-CoV-2 spike mutations and global vaccine efficacy against COVID-19.

Tokhanbigli, S Salami Ghaleh, S Rahimian, K Mahmanzar, M Bayat, S Ahangarzadeh, S Moradi, B Mahmanzar, R Wang, Y Oliver, BGG Deng, Y

In line with encountering the world with the emergence of vaccine-resistance variants of SARS-CoV-2, 15,669,529 samples that received COVID-19 vaccines until April 2023 were investigated as two dos...

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Dyslipidemia in asthma: Treatable trait, or just a common comorbidity?

Deng, K Wang, J Oliver, BG Wood, LG Wang, G

Asthma is a diverse disease that can be categorized into various phenotypes and endotypes, including obesity-re-lated asthma and allergic asthma. "Treatable traits (TTs)" represent a new approach t...

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Towards equitable cancer outcomes for rural and remote communities: reflections, lessons and recommendations

Ugalde, A Jongebloed, H Wright, C Rodi, H Chapman, A Marshall, S Aras, D Bergin, RJ Boffa, S Boltong, A Conlin, M Crawford–Williams, F de Wet, C Faisal, W Gao, L Gasper, H Gunn, K Hart, NH Hayes, T Honeyball, F Johnston, EA Karikios, D Kiss, N Leigh, L Livingston, PM O'Kane, C Perry, R Rhee, J Riva, S Sergeant, L Short, CE Stewart, R Turner, V Varlow, M Whittaker, K Shee, AW Yoong, S Alston, L

People living in rural and remote areas continue to face significant inequities in cancer outcomes compared to their metropolitan counterparts. Despite advances in cancer control, these disparities...

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Liraglutide-Driven Weight Loss Modulates Placental Remodeling in Obese Pregnancies in Mice.

Rodrigo, N Aksentijevic, D Patel, N Pollock, CA McClements, L Glastras, SJ

BACKGROUND: The placenta stands at the maternal-fetal interface and is a key organ regulating the intrauterine environment. In pregnancies exposed to obesity, placental function, signaling, and nut...

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Targeting trophoblast cell mitochondrial dysfunction in preeclampsia via drug repurposing.

Afrose, D Alfonso-Sánchez, S Philp, A Hansbro, PM Su, QP McClements, L

Preeclampsia is a multifactorial pregnancy disorder characterized by the new onset of hypertension and organ damage. Mitochondrial dysfunction is central to preeclampsia pathogenesis leading to pla...

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Designing and long-term planning for household hydrogen supply chain in Australia

Chakrabarty, P Paul, SK Trianni, A Saha, SC

This study presents the development of the long-term Household Hydrogen Supply Chain (HHSC) model, aimed at supporting the decarbonisation of household energy consumption. Structured across three s...

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